Multifunctional, Biocompatible Supramolecular Hydrogelators Consist Only of Nucleobase, Amino Acid, and Glycoside

Li, Xinming; Kuang, Yi; Shi, Junfeng; Gao, Yuan; Lin, Hsin‐Chieh; Xu, Bing

doi:10.1021/ja208456k

Cited by 119 publications

(113 citation statements)

References 83 publications

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“…Furthermore, such a relatively even fi brillar network may greatly benefi t the mechanical properties of RSF/HPMC9 hydrogel, because recent report have suggested that the formation of fi bril bundles could strengthen their mutual interactions, and thus contributed to the enhancement of the mechanical performance of hydrogel. [ 35 ] …”

Section: Fibrillar Network Of Rsf/hpmc9 Hydrogelsmentioning

confidence: 99%

Physically Crosslinked Biocompatible Silk‐Fibroin‐Based Hydrogels with High Mechanical Performance

Luo

Yang

Shao

2015

Adv Funct Materials

194

174

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have indeed shown greater mechanical performance than the traditional hydrogels. [8][9][10][11][12][13] However, problems still remained in terms of the applications of these hydrogels in biomedical fi elds. First, even if the elasticity of these hydrogels is improved signifi cantly, the modulus is far worse to meet the needs. Beyond that, poor biocompatibility as well as the possible toxicity of degradation product of these hydrogels poses a potential risk for the health of living beings. [ 6,7,14 ] Natural polymers, such as agarose, gelatin, hyaluronic acid and silk, possessing good biocompatibility, and the nontoxic degradation products, have received increasing interest in biomedical fi elds in the past decades. [ 15 ] Although these natural polymer based hydrogels have been extensively studied as the potential matrix for tissue engineering, the poor mechanical performance of the natural polymer based hydrogels is still a major limitation or a disadvantage for their medical applications. [ 16 ] Therefore, many methods were employed to improve the mechanical properties of the natural polymer based hydrogels. Chemical crosslinking was used as a facile routine approach to boost the mechanical properties of the natural polymer based hydrogels, but the safety of the chemical crosslinking reagent involved was a primary concern and the use of that might cause some unfavorable problems. [ 14 ] Besides chemical crosslinking, other efforts such as physical treatments [ 17,18 ] or mixing with other natural/synthetic polymers, [ 15,19 ] have been made to strengthen the natural polymer based hydrogels, yet the problem is still no closer to be solved.Among all natural polymers, Bombyx mori silk fi broin (SF) is one of the ideal candidates for biomedical applications due to it combining suffi cient mechanical performance, biocompatibility, and biodegradability. [20][21][22][23][24] Many approaches were employed to fabricate the physically crosslinked silk based hydrogels, such as sonication, vortex, addition of ethanol, and electrical fi eld. [25][26][27][28][29] However, most of the SF based hydrogels show poor mechanical performance which is a major stumbling block for applications. Recently, though a new covalently crosslinked SF based hydrogel with signifi cant elasticity was engineered via a kind of bio-crosslink reagent, i.e., HRP (horseradish peroxide), [ 7 ] it still could not escape the fate of poor mechanical properties in terms of the softness. Besides, the formation of the heterogeneous aggregates of crosslinking sites in the process of gelation can result in the poor optical properties Physically Crosslinked Biocompatible Silk-Fibroin-Based Hydrogels with High Mechanical PerformanceKunyuan Luo , Yuhong Yang , and Zhengzhong Shao * Developing hydrogel which combines superior mechanical performance and biocompatibility attracts researchers' attention in recent years. Here, a novel biocompatible hydrogel with excellent mechanical performance, comprised of regenerated silk fi broin (RSF) and hydroxypropyl methyl ce...

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Section: Fibrillar Network Of Rsf/hpmc9 Hydrogelsmentioning

confidence: 99%

Physically Crosslinked Biocompatible Silk‐Fibroin‐Based Hydrogels with High Mechanical Performance

Luo

Yang

Shao

2015

Adv Funct Materials

194

174

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“…Beside polymer-based gels, a particular class of hydrogels has more recently emerged that is generated by self-assembly of low molecular weight building blocks, which form supramolecular structures under particular physico-chemical conditions. For example, peptide-based gels have been developed that offer a high versatility in terms of chemical modifi cations and hence tuneable biological properties (Li et al, 2011;Matson et al, 2011). Thermosensitive hydrogels have the capacity to form gels as temperature increases above the critical solution temperature, designed to be below body temperature (Yu et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

A thermosensitive low molecular weight hydrogel as scaffold for tissue engineering

Ziane

Schlaubitz

Miraux

et al. 2012

eCM

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Hydrogels that are non-toxic, easy to use, cytocompatible, injectable and degradable are valuable biomaterials for tissue engineering and tissue repair. However, few compounds currently fulfi l these requirements. In this study, we describe the biological properties of a new type of thermosensitive hydrogel based on low-molecular weight glycosyl-nucleosyl-fl uorinated (GNF) compound. This gel forms within 25 min by self-assembly of monomers as temperature decreases. It degrades slowly in vitro and in vivo. It induces moderate chronic infl ammation and is progressively invaded by host cells and vessels, suggesting good integration to the host environment. Although human adult mesenchymal stem cells derived from adipose tissue (ASC) cannot adhere on the gel surface or within a 3D gel scaffold, cell aggregates grow and differentiate normally when entrapped in the GNF-based gel. Moreover, this hydrogel stimulates osteoblast differentiation of ASC in the absence of osteogenic factors. When implanted in mice, gel-entrapped cell aggregates survive for several weeks in contrast with gel-free spheroids. They are maintained in their original site of implantation where they interact with the host tissue and adhere on the extracellular matrix. They can differentiate in situ into alkaline phosphatase positive osteoblasts, which deposit a calcium phosphate-rich matrix. When injected into subcutaneous sites, gel-encapsulated cells show similar biological properties as implanted gel-cells complexes. These data point GNF-based gels as a novel class of hydrogels with original properties, in particular osteogenic potential, susceptible of providing new therapeutic solutions especially for bone tissue engineering applications.

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“…Moreover, the nanofibers of these hydrogelators exhibit significant interbase interactions with nucleic acids, which facilitate single strand oligonucleic acids entering cells and the nuclei of cells. [162] This feature is particularly attractive and warrants further exploration by incorporating different biofunctional peptides or molecular recognition motifs to achieve a wide range of biological functions, such as receptor targeting, nucleic acids condensation, blocking metabolism, endosomal escape, and nuclear localization.…”

Section: Supramolecular Hydrogels Made Of the Hybrids Of Basic Biomentioning

confidence: 99%

Supramolecular Hydrogels Made of Basic Biological Building Blocks

Zhou

2014

Chemistry An Asian Journal

Self Cite

113

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As a consequence of the self-assembly of small organic molecules in water, supramolecular hydrogels are evolving from serendipitous events during organic synthesis to become a new type of materials that promise increased applications in biomedicine. In this focus review, we describe the recent development on the use of basic biological building blocks for creating molecules that act as hydrogelators and the potential applications of the corresponding hydrogels. After introducing the concept of supramolecular hydrogels and defining the scope of this review, we briefly describe the methods for making and characterizing supramolecular hydrogels. Then, we discuss representative hydrogelators according to the categories of their building blocks, such as amino acids, nucleobases, and saccharides, and highlight the applications of the hydrogels when necessary. Finally, we offer our perspectives and outlooks on this fast-growing field at the interface of organic chemistry, materials, biology, and medicine. By providing a snapshot for chemists, engineers, and medical scientists, we hope that this focus review will contribute to the development of multidisciplinary research on supramolecular hydrogels for a wide range of applications in different fields.

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Multifunctional, Biocompatible Supramolecular Hydrogelators Consist Only of Nucleobase, Amino Acid, and Glycoside

Cited by 119 publications

References 83 publications

Physically Crosslinked Biocompatible Silk‐Fibroin‐Based Hydrogels with High Mechanical Performance

Physically Crosslinked Biocompatible Silk‐Fibroin‐Based Hydrogels with High Mechanical Performance

A thermosensitive low molecular weight hydrogel as scaffold for tissue engineering

Supramolecular Hydrogels Made of Basic Biological Building Blocks

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