Multifunctional carbon-coated magnetic sensing graphene oxide-cyclodextrin nanohybrid for potential cancer theranosis

Hsu, Yu-Hsuan; Hsieh, Hsiao-Yun; Viswanathan, Geetha; Voon, Siew Hui; Kue, Chin Siang; Saw, Wen Shang; Yeong, Chai Hong; Azlan, C. A.; Imae, Toyoko; Kiew, Lik Voon; Lee, Hong Boon; Chung, Lip Yong

doi:10.1007/s11051-017-4054-9

Cited by 28 publications

(9 citation statements)

References 57 publications

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“…Because of the richness of oxidized functional groups, GO has the possibility of many biomedical applications, including drug delivery, , biosensing, and bioimaging . To increase the biocompatibility and water dispersibility, GO was hybridized with hydrophilic polymers such as polyethylene glycol, sugar-based polymers, , and poly(amido amine) . On the other hand, fluorocarbons are excellent media of gases, in particular, of respiratory gases, because of their low intermolecular van der Waals interactions .…”

Section: Introductionmentioning

confidence: 99%

Nitric Oxide Gas Delivery by Fluorinated Poly(Ethylene Glycol)@Graphene Oxide Carrier toward Pharmacotherapeutics

Workie

Sabrina

Imae

et al. 2019

ACS Biomater. Sci. Eng.

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In view of preparing effective nitric oxide gas carriers, a fluorinated poly(ethylene glycol) (F-PEG) was non-covalently conjugated with acid-treated graphene oxide (GO) to prepare the composite of F-PEG@GO. When the persistence of NO gas doped on GO and F-PEG@GO was investigated for 3 h, the conserved NO gas decreased from 49.00±7.06 to 2.17±1.36 nmol/mg carrier and from 58.51± 6.02 to 4.58±2.22 nmol/mg carrier, respectively. The adsorption of F-PEG on GO and the doping of NO on GO and F-PEG@GO were declarative by the increase of distance between GO sheets, and the NO-doping was also clarified by infrared absorption and X-ray photoelectron spectroscopies. The anti-bacterial effect was higher for NO-conserved F-PEG@GO than for NO-conserved GO and more effective against Staphylococcus aureus than against Escherichia coli. It is evident that the coating of F-PEG on GO is preferable for advancing the loading efficiency, the stability and the biomedical efficacy of NO gas.

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Section: Introductionmentioning

confidence: 99%

Nitric Oxide Gas Delivery by Fluorinated Poly(Ethylene Glycol)@Graphene Oxide Carrier toward Pharmacotherapeutics

Workie

Sabrina

Imae

et al. 2019

ACS Biomater. Sci. Eng.

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“…In the reviewed studies the encapsulation efficiency could reach 95.8% for GbMNPs [ 20 ], which is exceptionally high compared to any other drug nanocarrier system described in the literature [ 69 ]. Doxorubicin (DOX) is the most studied chemotherapeutic drug [ 20 , 39 , 40 , 41 , 42 , 70 ]. Nevertheless, besides a high drug loading, the specific and timely delivering of the drugs to the targeted cells or tissues also have to be taken into account to achieve a successful therapeutic effect [ 4 ].…”

Section: Graphene-based Magnetic Nanoparticles For Theranosticsmentioning

confidence: 99%

“…In regard to the in vitro toxicity evaluation, most of the studies reviewed use MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay for cell viability evaluation in 2D static cultured cells [ 41 , 42 , 43 ]. However, this colorimetric assay is prone to producing false-positive/false-negative results, since any remaining GbMNPs in the solution to be analyzed can interfere with cell viability and proliferation results, due to the absorbance of light by the graphene-based shell [ 73 ].…”

Section: Graphene-based Magnetic Nanoparticles For Theranosticsmentioning

confidence: 99%

Graphene-Based Magnetic Nanoparticles for Theranostics: An Overview for Their Potential in Clinical Application

et al. 2021

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The combination of diagnostics and therapy (theranostic) is one of the most complex, yet promising strategies envisioned for nanoengineered multifunctional systems in nanomedicine. From the various multimodal nanosystems proposed, a number of works have established the potential of Graphene-based Magnetic Nanoparticles (GbMNPs) as theranostic platforms. This magnetic nanosystem combines the excellent magnetic performance of magnetic nanoparticles with the unique properties of graphene-based materials, such as large surface area for functionalization, high charge carrier mobility and high chemical and thermal stability. This hybrid nanosystems aims toward a synergistic theranostic effect. Here, we focus on the most recent developments in GbMNPs for theranostic applications. Particular attention is given to the synergistic effect of these composites, as well as to the limitations and possible future directions towards a potential clinical application.

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“…Multifunctional GO‐based IONPs nanohybrids have been also implemented which performed both as a drug delivery agent and a diagnostic agent. In here functionalized GO with cyclodextrin improved the loading of DOX and cellular uptake while carbon‐coated IONPs provided the targeted drug delivery and magnetic resonance imaging (MRI) imaging ability (Hsu et al, ). However, intracellular localization analyzed with dual staining confocal microscopy and flowcytometry confirmed that these nanocarriers are localized mainly in the nucleus with a lesser content in the cytoplasm.…”

Section: Different Types Of Oinhsmentioning

confidence: 99%

Recent developments in the use of organic–inorganic nanohybrids for drug delivery

Manatunga

Godakanda

Silva

et al. 2019

WIREs Nanomed Nanobiotechnol

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Organic–inorganic nanohybrid (OINH) structures providing a versatile platform for drug delivery with improved characteristics are an area which has gained recent attention. Much effort has been taken to develop these structures to provide a viable treatment options for much alarming diseases such as cancer, bone destruction, neurological disorders, and so on. This review focuses on current work carried out in producing different types of hybrid drug carriers identifying their properties, fabrication techniques, and areas where they have been applied. A brief introduction on understating the requirement for blending organic–inorganic components into a nanohybrid drug carrier is followed with an elaboration given about the different types of OINHs developed currently highlighting their properties and applications. Then, different fabrication techniques are discussed given attention to surface functionalization, one‐pot synthesis, wrapping, and electrospinning methods. Finally, it is concluded by briefing the challenges that are remaining to be addressed to obtain multipurpose nanohybrid drug carriers with wider applicability. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Multifunctional carbon-coated magnetic sensing graphene oxide-cyclodextrin nanohybrid for potential cancer theranosis

Cited by 28 publications

References 57 publications

Nitric Oxide Gas Delivery by Fluorinated Poly(Ethylene Glycol)@Graphene Oxide Carrier toward Pharmacotherapeutics

Nitric Oxide Gas Delivery by Fluorinated Poly(Ethylene Glycol)@Graphene Oxide Carrier toward Pharmacotherapeutics

Graphene-Based Magnetic Nanoparticles for Theranostics: An Overview for Their Potential in Clinical Application

Recent developments in the use of organic–inorganic nanohybrids for drug delivery

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