Multifunctional Carbon Nanodots: Enhanced Near‐Infrared Photosensitizing, Photothermal Activity, and Body Clearance

Ji, Ding‐Kun; Dali, Hayet; Guo, Shi; Malaganahally, Sowmya; Vollaire, Julien; Josserand, Véronique; Dumortier, Hélène; Ménard‐Moyon, Cécilia; Bianco, Alberto

doi:10.1002/smsc.202100082

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…Overall, the irradiation effect not only inhibited the cell proliferation, but also induced cell death, revealing the key role of photothermal and PDT effects. [ 47 ]…”

Section: Resultsmentioning

confidence: 99%

Mechanisms of Radical Formation on Chemically Modified Graphene Oxide under Near Infrared Irradiation

Jacquemin

Zhang

Breton

et al. 2023

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Carbon-based nanomaterials exist in different forms, and the key which links all these nanomaterials lies in the high percentage of carbon atoms connected through sp 2 or sp 3 bonds. The small size and the different properties of these materials stir a strong interest in different application fields from electronics to biomedicine. Especially, carbon-based nanomaterials have received a growing interest due to their interaction with light. [1] This property can be exploited in a wide variety of applications, including phototherapy. The therapeutic benefit of phototherapy lies on an easy and flexible control of the light irradiation, the possibility to treat specific localized areas, as well as control time and dose of the therapeutic action. [2] Depending on their interaction with light, two classes of phototherapies can operate. The first is the photothermal therapy (PTT), which consists of the conversion of the adsorbed light by a material into surface vibrations producing heat. The local increase of the temperature can induce photoablation of tumor cells. [3] The second is the photodynamic therapy (PDT), where the interaction with light produces free radicals and, most importantly, reactive oxygen species (ROS). This leads to high oxidative stress that destabilizes cell machinery and induces apoptosis. [4] PDT is currently the most explored type of phototherapy for cancer treatment. Compared to PTT, PDT was already approved by FDA. [5] Within the different classes of carbon materials, graphene family nanomaterials have gained a lot of consensuses as tools in cancer therapy. They are composed of hexagonal rings of carbon with electron delocalization depending on the type of graphene material. [6] These 2D materials are good photothermal agents due to their ability to absorb at near-infrared (NIR) wavelengths. [7] Graphene generally shows poor colloidal stability, and this limits its use in drug delivery. [8] Graphene oxide (GO) is the oxidized form of graphene. The oxidative synthesis process enriches GO surface with a wide variety of organic groups such as epoxides, hydroxyl and carboxyl groups. [8] Because of its biocompatibility, hydrophilicity, high colloidal stability, and versatile surface chemistry, the biomedical applications of GO have been widely explored. In addition, GO can be easily

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“…Overall, the irradiation effect not only inhibited the cell proliferation, but also induced cell death, revealing the key role of photothermal and PDT effects. [ 47 ]…”

Section: Resultsmentioning

confidence: 99%

Mechanisms of Radical Formation on Chemically Modified Graphene Oxide under Near Infrared Irradiation

Jacquemin

Zhang

Breton

et al. 2023

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“…CDs with good biocompatibility and water solubility can be excellent carriers for PSs, either by chemical grafting or non-covalent assembly. To date, many NIR PSs, such as Ce6 [ 58 , 59 ], protoporphyrin [ 60 ], Aminoporphyrins [ 61 ], and Protoporphyrin IX [ 62 ] have been integrated with water-soluble CDs, resulting in a number of NCDs with high biodispersibility and NIR photosensitivity.…”

Section: Preparation Of Pncdsmentioning

confidence: 99%

Recent Advances of Photoactive Near-Infrared Carbon Dots in Cancer Photodynamic Therapy

et al. 2023

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Photodynamic therapy (PDT) is a treatment that employs exogenously produced reactive oxygen species (ROS) to kill cancer cells. ROS are generated from the interaction of excited-state photosensitizers (PSs) or photosensitizing agents with molecular oxygen. Novel PSs with high ROS generation efficiency is essential and highly required for cancer photodynamic therapy. Carbon dots (CDs), the rising star of carbon-based nanomaterial family, have shown great potential in cancer PDT benefiting from their excellent photoactivity, luminescence properties, low price, and biocompatibility. In recent years, photoactive near-infrared CDs (PNCDs) have attracted increasing interest in this field due to their deep therapeutic tissue penetration, superior imaging performance, excellent photoactivity, and photostability. In this review, we review recent progress in the designs, fabrication, and applications of PNCDs in cancer PDT. We also provide insights of future directions in accelerating the clinical progress of PNCDs.

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“…Carbon dots (CDs) are gaining increasing attention in the biomaterial field due to their excellent optical properties, low toxicity, high water dispersibility, low price of production. − Carbon dots were discovered in 2004 as prominent photoluminescent materials during the electrophoretic purification of arc-synthesized single-walled carbon nanotubes (SWCNTs) . CDs have a size below 10 nm, typically hovering around 5 nm, and exhibit the morphology of tiny quasi-spherical nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Recent Progress on Second Near-Infrared Emitting Carbon Dots in Biomedicine

Yang,

Han,

Bianco

et al. 2024

ACS Nano

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Second near-infrared (NIR-II) carbon dots, with absorption or emission between 1000 and 1700 nm, are gaining increasing attention in the biomaterial field due to their distinctive properties, which include straightforward preparation processes, stable photophysical characteristics, excellent biocompatibility, and low cost. As a result, there is a growing focus on the controlled synthesis and modulation of the photochemical and photophysical properties of NIR-II carbon dots, with the aim to further expand their biomedical applications, a current research hotspot. This account aims to provide a comprehensive overview of the recent advancements in NIR-II carbon dots within the biomedical field. The review will cover the following topics: (i) the design, synthesis, and purification of NIR-II carbon dots, (ii) the surface modification strategies, and (iii) the biomedical applications, particularly in the domain of cancer theranostics. Additionally, this account addresses the challenges encountered by NIR-II carbon dots and will outline future directions in the realm of cancer theranostics. By exploring carbon-based NIR-II biomaterials, we can anticipate that this contribution will garner increased attention and contribute to the development of next-generation advanced functional carbon dots, thereby offering enhanced tools and strategies in the biomedical field.

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Multifunctional Carbon Nanodots: Enhanced Near‐Infrared Photosensitizing, Photothermal Activity, and Body Clearance

Cited by 6 publications

References 36 publications

Mechanisms of Radical Formation on Chemically Modified Graphene Oxide under Near Infrared Irradiation

Mechanisms of Radical Formation on Chemically Modified Graphene Oxide under Near Infrared Irradiation

Recent Advances of Photoactive Near-Infrared Carbon Dots in Cancer Photodynamic Therapy

Recent Progress on Second Near-Infrared Emitting Carbon Dots in Biomedicine

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