Multifunctional carbon nanomateriels for camptothecine low-water soluble anticancer drug delivery

Itatahine, Asma; Mehdi, Yamina Ait; Fizir, Meriem; Qi, Man; Dramou, Pierre; He, Hua

doi:10.1039/c7nj04609j

Cited by 12 publications

(9 citation statements)

References 39 publications

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“…It was observed that GQDs were biocompatible and the biotin-linked GQDs loaded with DOX proved to have greater uptake rather than free DOX or GQDs-DOX in A549 cell line. 47 A system based on decorated magnetic nanoparticles onto GO layered by mesoporous silica was developed for camptothecin (CPT) delivery. The carriers have a capacity of 20% regarding drug loading and showed a controlled and pH-responsive drug release.…”

Section: Dovepressmentioning

confidence: 99%

“…To be specific, smaller flakes showed less toxicity. 47 Considering the size of graphene is also important to think about the mechanism by which the material internalizes into a target cell. 16 Overall, regarding the presented information, it is worthwhile noting that examining a study concerned with graphenebased materials, many factors and properties including size of the material, shape, functionalization, functionalizing groups and percent of these reactions, in-vivo concentration, pharmacokinetic and pharmacodynamics of the materials must carefully be considered.…”

Section: Future Trendsmentioning

confidence: 99%

“…It was observed that GQDs were biocompatible and the biotin-linked GQDs loaded with DOX proved to have greater uptake rather than free DOX or GQDs-DOX in A549 cell line. 47 …”

Section: Drug Delivery Applicationsmentioning

confidence: 99%

“…Moreover, under suitable magnetic properties along with high adsorption capacity, it was deemed a beneficial and versatile nanoplatform with the aim of tumor chemotherapy using magnetic targeting. 47 …”

Section: Drug Delivery Applicationsmentioning

confidence: 99%

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<p>Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?</p>

Hoseini‐Ghahfarokhi¹,

Mirkiani²,

Mozaffari³

et al. 2020

IJN

165

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Graphene, a wonder material, has made far-reaching developments in many different fields such as materials science, electronics, condensed physics, quantum physics, energy systems, etc. Since its discovery in 2004, extensive studies have been done for understanding its physical and chemical properties. Owing to its unique characteristics, it has rapidly became a potential candidate for nano-bio researchers to explore its usage in biomedical applications. In the last decade, remarkable efforts have been devoted to investigating the biomedical utilization of graphene and graphene-based materials, especially in smart drug and gene delivery as well as cancer therapy. Inspired by a great number of successful graphene-based materials integrations into the biomedical area, here we summarize the most recent developments made about graphene applications in biomedicine. In this paper, we review the up-to-date advances of graphene-based materials in drug delivery applications, specifically targeted drug/ gene delivery, delivery of antitumor drugs, controlled and stimuli-responsive drug release, photodynamic therapy applications and optical imaging and theranostics, as well as investigating the future trends and succeeding challenges in this topic to provide an outlook for future researches.

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Section: Dovepressmentioning

confidence: 99%

Section: Future Trendsmentioning

confidence: 99%

“…It was observed that GQDs were biocompatible and the biotin-linked GQDs loaded with DOX proved to have greater uptake rather than free DOX or GQDs-DOX in A549 cell line. 47 …”

Section: Drug Delivery Applicationsmentioning

confidence: 99%

Section: Drug Delivery Applicationsmentioning

confidence: 99%

See 2 more Smart Citations

<p>Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?</p>

Hoseini‐Ghahfarokhi¹,

Mirkiani²,

Mozaffari³

et al. 2020

IJN

165

View full text Add to dashboard Cite

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“…Recently, magnetic GO and magnetic CNTs were ensheathed with mesoporous silica, for the loading and delivery of CPT. The complex of prepared nanomaterials and CPT evinced remarkably high cytotoxicity towards HeLa cell lines compared to the pure drug …”

Section: Applications Of Carbon Nanomaterials In the Cancer Therapymentioning

confidence: 99%

Carbon Nanomaterials for Targeted Cancer Therapy Drugs: A Critical Review

Hosnedlová

Kępińska

Fernandez

et al. 2018

The Chemical Record

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Cancer represents one of the main causes of human death in developed countries. Most current therapies, unfortunately, carry a number of side effects, such as toxicity and damage to healthy cells, as well as the risk of resistance and recurrence. Therefore, cancer research is trying to develop therapeutic procedures with minimal negative consequences. The use of nanomaterial-based systems appears to be one of them. In recent years, great progress has been made in the field using nanomaterials with high potential in biomedical applications. Carbon nanomaterials, thanks to their unique physicochemical properties, are gaining more and more popularity in cancer therapy. They are valued especially for their ability to deliver drugs or small therapeutic molecules to these cells. Through surface functionalization, they can specifically target tumor tissues, increasing the therapeutic potential and significantly reducing the adverse effects of therapy. Their potential future use could, therefore, be as vehicles for drug delivery. This review presents the latest findings of research studies using carbon nanomaterials in the treatment of various types of cancer. To carry out this study, different databases such as Web of Science, PubMed, MEDLINE and Google Scholar were employed. The findings of research studies chosen from more than 2000 viewed scientific publications from the last 15 years were compared.

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Polyoxazoline‐modified graphene oxides with improved water and epoxy resin dispersibility and stability towards composite applications

Şahin

Kohlan

Atespare

et al. 2022

J of Applied Polymer Sci

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Graphene oxide (GO) is modified with poly(2-ethyl-2-oxazoline) (PEOZ) and poly [(2-ethyl-2-oxazoline-co-(ethylenimine)] (PEOZ-PEI) to enhance its dispersibility in water and epoxy resin. PEOZ with a terminal primary amine and POZ-PEI with multiple backbone secondary amines are synthesized with scalable methods and characterized by nuclear magnetic resonance (NMR), Fourier transform infrared (FTIR), and gel permeation chromatography (GPC). GO modifications are performed at room temperature and 90 C with/without N,N 0 -dicyclohexylcarbodiimide (DCC) and modified-GOs are analyzed by FTIR, thermogravimetric analysis (TGA), and scanning electron microscopyenergy-dispersive X-ray spectroscopy (SEM-EDX). It is observed that the polymer incorporation varies based on the reaction condition, polymer type, and functional group type and position. The dispersion quality and stability of modified GOs are studied in water by particle size analyzer and visually and in epoxy resin by rheometer. PEOZ-modified GOs show better dispersibility and stability than PEOZ-PEI-modified GOs in both media since PEOZ is monofunctional, preventing the agglomerate formation and improving polymer exposure to the dispersion media by its longer length and higher water-solubility, whereas PEOZ-PEI has lower water solubility, multiple amines for interactions leading to agglomeration and limited polymer exposure to the dispersion media. The tailorable polymer grafting and the increased dispersibility of modified GOs in both media are promising indicators of their possible applications in composites.

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Multifunctional carbon nanomateriels for camptothecine low-water soluble anticancer drug delivery

Abstract: A multifunctional hybrid nanomaterial of magnetic graphene oxide (GO) and magnetic carbon nanotubes (CNTs) was ensheathed with mesoporous silica, for the loading and delivery of an anticancer drug, camptothecine (CPT).

Cited by 12 publications

References 39 publications

<p>Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?</p>

<p>Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?</p>

Carbon Nanomaterials for Targeted Cancer Therapy Drugs: A Critical Review

Polyoxazoline‐modified graphene oxides with improved water and epoxy resin dispersibility and stability towards composite applications

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