Multifunctional Cargo-Free Nanomedicine for Cancer Therapy

Wang, Ying; Yang, Pengfei; Zhao, Xiaomin; Gao, Di; Sun, Na; Tian, Zhongmin; Ma, Teng; Yang, Zhe

doi:10.3390/ijms19102963

Cited by 28 publications

(10 citation statements)

References 109 publications

(132 reference statements)

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“…This method can improve the therapy by localizing the treatment to tumor sites and reducing the side effects to normal cells [80]. PTT is another light-excited treatment method, which converts the light energy into heat under specific near-infrared (NIR) laser leading to tumor ablation [81]. In spite of these advantages, phototherapeutic agents have some drawbacks such as instability stemming from their insolubility and poor selectivity which weakens the therapeutic effect [79].…”

Section: Self-assembly Of Chemotherapy With Photodynamic or Photothermal Therapy Drug Moleculesmentioning

confidence: 99%

Carrier-free nanodrugs for safe and effective cancer treatment

Karaosmanoglu

Zhou

Shi

et al. 2021

Journal of Controlled Release

129

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Clinical applications of many anti-cancer drugs are restricted due to their hydrophobic nature, requiring use of harmful organic solvents for administration, and poor selectivity and pharmacokinetics resulting in off-target toxicity and inefficient therapies. A wide variety of carrier-based nanoparticles have been developed to tackle these issues, but such strategies often fail to encapsulate drug efficiently and require significant amounts of inorganic and/or organic nanocarriers which may cause toxicity problems in the long term. Preparation of nanoformulations for the delivery of water insoluble drugs without using carriers is thus desired, 2 requiring elegantly designed strategies for products with high quality, stability and performance. These strategies include simple self-assembly or involving chemical modifications via coupling drugs together or conjugating them with various functional molecules such as lipids, carbohydrates and photosensitizers. During nanodrugs synthesis, insertion of redox-responsive linkers and tumor targeting ligands endows them with additional characteristics like on-target delivery, and conjugation with immunotherapeutic reagents enhances immune response alongside therapeutic efficacy. This review aims to summarize the methods of making carrier-free nanodrugs from hydrophobic drug molecules, evaluating their performance, and discussing the advantages, challenges, and future development of these strategies.

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Section: Self-assembly Of Chemotherapy With Photodynamic or Photothermal Therapy Drug Moleculesmentioning

confidence: 99%

Carrier-free nanodrugs for safe and effective cancer treatment

Karaosmanoglu

Zhou

Shi

et al. 2021

Journal of Controlled Release

129

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“…The forms of these nano-scale drug delivery systems vary considerably, from large polymers with polyethylene glycols [19] to moderate compositions with metals or quantum dots [20,21] to small nanoparticles with antineoplastic drugs [22,23]. Regardless of the form of the delivery system, the objective of improving efficacy and reducing toxicity can be achieved, confirming the advantages of nano-scale drug delivery systems [24,25].…”

Section: Introductionmentioning

confidence: 99%

Novel Targeted Anti-Tumor Nanoparticles Developed from Folic Acid-Modified 2-Deoxyglucose

Jin

Guo³

et al. 2019

IJMS

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The glucose analog, 2-deoxyglucose (2-DG), specifically inhibits glycolysis of cancer cells and interferes with the growth of cancer cells. However, the excellent water solubility of 2-DG makes it difficult to be concentrated in tumor cells. In this study, a targeted nano-pharmacosome was developed with folic acid-modified 2-DG (FA-2-DG) by using amino ethanol as a cleavable linker. FA-2-DG was able to self-assemble, forming nano-particles with diameters of 10–30 nm. The biological effects were evaluated with cell viability assays and flow cytometry analysis. Compared with a physical mixture of folic acid and 2-DG, FA-2-DG clearly reduced cell viability and resulted in cell cycle arrest. A computational study involving docking simulation suggested that FA-2-DG can dock into the same receptor as folic acid, thus confirming that the structural modification did not affect the targeting performance. The results indicated that the nano-pharmacosome consisting of FA-2-DG can be used for targeting in a nano-drug delivery system.

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“…Using nanoparticles (NP) to deliver drugs to cells (nanomedicine) was foreseen to be a true game-changer of the 21 st century in improving the prevention, diagnosis and therapy of various therapeutic areas (1)(2)(3)(4)(5)(6). The potential of these nanosized carriers in pharmaceutical applications has been envisioned since the 1970's to improve the delivery of therapeutic and imaging agents to specific target sites (7)(8)(9)(10)(11). The remarkable interest in NP is attributed to the plethora of physical and biological advantages they offer in comparison to conventional medicines, such as: improved efficacy and safety, enhanced solubility and pharmacokinetic profile, and increased target selectivity (12-15).…”

Section: Introductionmentioning

confidence: 99%