Multifunctional cell membranes-based nano-carriers for targeted therapies: a review of recent trends and future perspective

Abstract

Nanotechnology has ignited a transformative revolution in disease detection, prevention, management, and treatment. Central to this paradigm shift is the innovative realm of cell membrane-based nanocarriers, a burgeoning class of biomimetic nanoparticles (NPs) that redefine the boundaries of biomedical applications. These remarkable nanocarriers, designed through a top-down approach, harness the intrinsic properties of cell-derived materials as their fundamental building blocks. Through shrouding themselves in natural cell membranes, these nanocarriers extend their circulation longevity and empower themselves to intricately navigate and modulate the multifaceted microenvironments associated with various diseases. This comprehensive review provides a panoramic view of recent breakthroughs in biomimetic nanomaterials, emphasizing their diverse applications in cancer treatment, cardiovascular therapy, viral infections, COVID-19 management, and autoimmune diseases. In this exposition, we deliver a concise yet illuminating overview of the distinctive properties underpinning biomimetic nanomaterials, elucidating their pivotal role in biomedical innovation. We subsequently delve into the exceptional advantages these nanomaterials offer, shedding light on the unique attributes that position them at the forefront of cutting-edge research. Moreover, we briefly explore the intricate synthesis processes employed in creating these biomimetic nanocarriers, shedding light on the methodologies that drive their development.

Nano-Food Farming: Toward Sustainable Applications of Proteins, Mushrooms, Nano-Nutrients, and Nanofibers

“…The first group is edible mushrooms, the second group is protein-based nanoparticles, the third group is nano-nutrients, and the last group is nanofibers. The use of nanotechnology in agri-food production can be noticed in several sectors, such as nano-/biosensors for detecting pathogens [83], nano-management of agrowastes [84,85], nano-enhancement of the shelf-life of agri-products [86], nano-identification and tracking of agri-foods [87], nano-agrochemicals for crop improvement [88], nanofibers for wastewater treatment [58,89], nano-or bio-remediation of soil and water [90], and nanocarriers to provide targeted delivery of treatments [91]. For example, the most common nanomaterial-based sensors include magnetic NPs, gold NPs, silica NPs, carbon nanotubes, peptide nanotubes, and quantum dots, which are used to detect different pathogens and their toxins [92].…”

Nano-Food Farming Approaches to Mitigate Heat Stress under Ongoing Climate Change: A Review

“…Recently, many reports have confirmed that nanotechnology can contribute to global food security amid the escalating challenges posed by the growth of the global population and the impacts of climate change [43,182,[186][187][188]. The use of nanomaterials in producing food has received substantial investigation, such as nano-identification and tracking of agri-foods [189], nano-management of agro-wastes [190,191], nano-biosensors to detect pathogens [192], nano-enhancement of the shelf-life of agri-products [193], nanoagrochemicals for crop improvement [179], nanofibers for wastewater treatment [194], nano-bio-remediation of soil and water [195], and nano-carriers to provide targeted delivery of treatments [196]. These areas of nanomaterials research help address the overarching issue of global food security.…”

The Optimization Design of Macrophage Membrane Camouflaging Liposomes for Alleviating Ischemic Stroke Injury through Intranasal Delivery

“…Cell membrane-coated nanomaterials have become a new and promising nanotechnology [ 32 , 33 ]. This biomimetic nano delivery system’s uniqueness lies in its ability to utilize affinity ligands on the cell membrane to achieve targeted therapy for diseases, thereby improving its therapeutic effect [ 34 , 35 ]. For example, macrophage membrane-coated liposomes can play an important role in targeted drug delivery; these stealth liposomes allow liposomal cloaking into macrophage membranes and can protect the liposomes from phagocytic uptake by the immune cells, whereas the surface-wrapped macrophage membranes allow for the recognition of antigens and target inflamed tissues [ 36 ].…”