membrane-type metamaterials, [17] recent work has shown that integrating liquids with the solid structures can dramatically assist reconfigurability. Recently a passively reconfigurable Helmholtz resonator was illustrated, where different volumes of water were filled to tune its free cavity space. [18] However, for actively tuning the liquid embedded metamaterial designs, we need active microfluidic techniques for on-chip control of liquid mobility. A number of active microfluidic control mechanisms [19] exist in literature like photo-electrowetting, electrophoresis, and surface acoustic waves. These can be used to move microscale droplets in a controlled manner, and have been explored for various applications like lab-on-a-chip, [20] printing, [21] opto-fluidic lensing, [22] and acousto-fluidics. [23] However, the field of acousto-fluidics [24] has to-date focused only upon manipulating liquid droplets using applied acoustic fields [25,26] and not vice versa. Furthermore, there are fabrication challenges in making ultra-compact tunable metamaterial designs, because of the large dimensions, low throughput, bulk geometries, and huge material costs required for incorporating active control mechanisms. Here, we propose and develop a novel ultra-compact metastructure, which we refer as a metamaterial, with an active actuation mechanism utilizing microfluidics, that will be practically significant and promote a new approach toward microfluidic acoustic metamaterials (MAMs).In this paper, we design, fabricate, and demonstrate a droplet integrated metamaterial, which derives its tunability from a digital microfluidics based active droplet manipulation technique called electrowetting-on-dielectric (EWOD). [27][28][29] We achieve dynamic control of a deep sub-wavelength slit (dimensions, length = 0.5 λ (L), width = 0.06 λ, and height = 0.02 λ) for manipulating ultrasound (40 kHz) by using microelectromechanical (MEMS) technology. Ultrathin deep subwavelength metamaterial for example, around λ/650 at the frequency of 20.9 kHz (λ denotes the wavelength of sound), where arbitrary patterns were paper-cut by hollow-out patterning on metasurfaces, seldom exist in literature. [30] Most of the reported works like ultrasonic meta-lens [31] which range within µm to mm scale are "passive," but here we propose a novel actively tunable deep subwavelength ultrathin metamaterial (200 µm in thickness, up to λ/44), establishing a record in comparison with previous works to our best knowledge. MEMS based MAM design paves While acoustic metamaterials provide extraordinary control to manipulate sound waves, their physical realization and applicability are severely impeded by the limited tunability, narrow operational frequency range, and noncompact designs. Integrating liquids with active actuation mechanism in the metamaterials provides broader material and design scope. Active microfluidic techniques for liquid actuation, never used in metamaterials before, will enable active tunability for liquid-embedded metamaterial designs, leading tow...