In this paper, we used the aqueous extract of the Zygophyllum Coccineum Plant Leaves for the synthesis of ZnO green method utilizing zinc acetate dihydrate as a precursor. The synthesized zinc oxide NPs was characterized by (Atomic Force Microscopy), UV-Vis. (UV (X-Ray Diffraction), FE-SEM (Field emission Scanning Electron Microscopy), and EDX Spectroscopy). We investigate the topography of the wavelength of the sample was 368 nm and Eg was 3.3714 e. V. The absorption peak appears presence of ZnO-NPs nanoparticles. X-ray diffraction studies represent t Scherrer formula that proposed ZnO-NPs have a hexagonal structure. The purity of zinc oxide NPs formation and the percentage of elements in nanoparticles structure were proven by EDX. SEM testing using the i that spherical shapes of nanoparticles agree with XRD analysis.