Multifunctional Enzyme Inhibition for Neuroprotection - A Focus on MAO, NOS, and AChE Inhibitors

Joubert, Jacques; Petzer, Jacobus P.; Prins, Louis H.A.; Repsold, Benjamin P.; Malan, Sarel F.

doi:10.1016/b978-0-12-803959-5.50005-2

Cited by 2 publications

(2 citation statements)

References 264 publications

(298 reference statements)

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“…MAO-A inhibitors increase the levels of noradrenaline and serotonin in the brain and are employed to treat anxiety and depression. On the other hand, MAO-B inhibitors are useful for PD symptomatic therapy [8].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Potential of Verbascoside Isolated from Acanthus mollis L. Leaves through Its Enzymatic Inhibition and Free Radical Scavenging Ability

Burgos,

Muñoz-Mingarro,

Navarro

et al. 2020

Antioxidants

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The phenomenon of today’s ageing population has increased interest in the search for new active substances that delay the onset and development of neurodegenerative diseases. In this respect, the search for natural compounds, mainly phenolic compounds, with neuroprotective activity has become the focus of growing interest. Verbascoside is a phenylethanoid that has already presented several pharmacological activities. The purpose of this study is to isolate and identify verbascoside from Acanthus mollis leaves. Consequently, its neuroprotective ability through enzymatic inhibition and free radical scavenging ability has been analyzed both in vitro and in cell culture assays. The antioxidant capacity of verbascoside was evaluated in vitro through total antioxidant capacity, DPPH•, OH•, and O2•—scavenging activity assays. The effect of verbascoside on intracellular reactive oxygen species (ROS) levels of HepG2 and SH-SY5Y cell lines was studied in normal culture and under induced oxidative stress. The inhibitory ability of the phenylethanoid against several enzymes implied in neurodegenerative diseases (tyrosinase, MAO-A, and AChE) was analyzed in vitro. Verbascoside neuroprotective activity is at least in part related to its free radical scavenging ability. The effect of verbascoside on ROS production suggests its potential in the prevention of harmful cell redox changes and in boosting neuroprotection.

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Section: Introductionmentioning

confidence: 99%

Neuroprotective Potential of Verbascoside Isolated from Acanthus mollis L. Leaves through Its Enzymatic Inhibition and Free Radical Scavenging Ability

Burgos,

Muñoz-Mingarro,

Navarro

et al. 2020

Antioxidants

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show abstract

“…SP shows various pharmacological properties [ 1 , 7 ], such as anti-inflammatory and antioxidant activity as well as scavenging of reactive oxygen species. Moreover, it has been reported to have beneficial effects in the case of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease [ 7 – 9 ]. Due to its great potential, an increasing number of research activities have been focused on better investigating the properties of SP.…”

Section: Introductionmentioning

confidence: 99%

An insight into polyscopoletin electrosynthesis by a quality-by-design approach

et al. 2022

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Scopoletin (SP) as a functional monomer for electropolymerization has recently been investigated in the context of molecularly imprinted polymers for biosensing applications. Herein we describe an in-depth analysis of the mechanisms involved in the electropolymerization of SP toward the optimization of the experimental conditions for applications in sensor studies. PolySP films have been in situ synthesized on a standard glassy carbon electrodes by varying three independent experimental parameters, and the output of the analysis has been evaluated in terms of the resulting electroactive area and surface coverage. A quality-by-design approach including design-of-experiments principles and response surface methodology produced unbiased observations on the most relevant parameters to be controlled during the electropolymerization of SP. By combining the output of electroactive area and surface overage, we highlighted a strong dependence on the monomer concentration and scan rate. Thus, an appropriate selection of these two parameters should be sought to have an optimal electropolymerization process, leading to uniform films and homogeneous surface behavior. This study shows that the application of multi-factorial analysis in a comprehensive design of experiments allows the systematic study of polymer electrosynthesis. Therefore, this research is expected to guide further efforts in the electropolymerization of several functional monomers.

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Multifunctional Enzyme Inhibition for Neuroprotection - A Focus on MAO, NOS, and AChE Inhibitors

Cited by 2 publications

References 264 publications

Neuroprotective Potential of Verbascoside Isolated from Acanthus mollis L. Leaves through Its Enzymatic Inhibition and Free Radical Scavenging Ability

Neuroprotective Potential of Verbascoside Isolated from Acanthus mollis L. Leaves through Its Enzymatic Inhibition and Free Radical Scavenging Ability

An insight into polyscopoletin electrosynthesis by a quality-by-design approach

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