Multifunctional Eu-doped carbon dots nanoprobe for highly sensitive and selective determination of glutathione in biological fluid and cell imaging

Al-mashriqi, Haitham Saad; Sanga, Pascaline; Chen, Jia; Qaed, Eskandar; Xiao, Jing; Li, Xin; Qiu, Hongdeng

doi:10.1016/j.carbon.2024.119380

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Cited by 5 publications

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Eco-friendly carbon dots: New prospects in analytical chemistry

Gupta,

Rajora,

Bal

2024

Comprehensive Analytical Chemistry

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Eco-friendly carbon dots: New prospects in analytical chemistry

Gupta,

Rajora,

Bal

2024

Comprehensive Analytical Chemistry

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Ionic liquid-derived carbon dots with enhanced antibacterial activity and antibiofilm capability for treatment of MRSA-infected wounds

Gao,

Qu,

et al. 2024

Chemical Engineering Journal

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Glutathione-Conjugated Fluorometric Ratiometric NIR-Silicon Nanoparticles and Its Applications for In Vitro and In Vivo Imaging

Iradukunda,

Kang,

Zhao

et al. 2024

ACS Appl. Bio Mater.

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Glutathione (GSH), a tripeptide molecule, is the most abundant nonprotein biothiol in living cells, playing a crucial role in preventing oxidative damage to cellular components and maintaining intracellular redox homeostasis. As a thiol molecule, GSH contains a sulfhydryl (−SH) group that is vital for the body's response to reactive oxygen species (ROS). To confirm whether GSH can be used as a bioindicator or in the early diagnosis of cancers at the cellular level, it is essential to achieve highly selective detection and conjugation of GSH to silicon nanoparticles (SiNPs) under pathological conditions. We are herein excited to report a type of fluorescent ratiometric near-infrared silicon nanoparticle (NIR-SiNP) probe, that is, glutathione peptide conjugated (NIR-SiNPs-GSH), which simultaneously possess small pore sizes at an average of 6.7 nm, an emission of 670 nm, a bioimaging functionality of living cancer cells and animals, and favorable biocompatibility. Taking advantage of these virtues, we further manifest that such resulting NIR-SiNPs, NIR-SiNPs-GSH bioprobes are marvelously worthy for immunofluorescence imaging of cancer cells and living mice. Furthermore, it was shown that DAPI and probes could selectively stain malignant tumor cell nuclei, indicating the possibility for bioimaging and identification of cancer cells and animals. In summary, the suggested NIR-SiNPs-GSH probe has the potential to be a very effective chemical tool for early tumor detection in the future.

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Multifunctional Eu-doped carbon dots nanoprobe for highly sensitive and selective determination of glutathione in biological fluid and cell imaging

Cited by 5 publications

References 55 publications

Eco-friendly carbon dots: New prospects in analytical chemistry

Eco-friendly carbon dots: New prospects in analytical chemistry

Ionic liquid-derived carbon dots with enhanced antibacterial activity and antibiofilm capability for treatment of MRSA-infected wounds

Glutathione-Conjugated Fluorometric Ratiometric NIR-Silicon Nanoparticles and Its Applications for In Vitro and In Vivo Imaging

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