Multifunctional Fe3O4–TiO2 nanocomposites for magnetic resonance imaging and potential photodynamic therapy

Zeng, Leyong; Ren, Wenzhi; Xiang, Lingchao; Zheng, Jianjun; Chen, Bin; Wu, Aiguo

doi:10.1039/c3nr33978e

Cited by 115 publications

(77 citation statements)

References 35 publications

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“…Moreover, magnetic nanomaterials were also used to load PS for simultaneous MRI and PDT [5][6][7][8]. In previous reports, multifunctional nanoprobes of MRI/PDT were generally organic PS-loaded 35 superparamagnetic/paramagnetic nanomaterials for T 1 -or T 2 -weighted MRI and visible-triggered organic PDT [5][6][7][8][9][10][11][12], and inorganic PS-loaded superparamagnetic nanomaterials for MRI and visible/ultraviolet (UV)-triggered inorganic PDT [13,14]. At present, the clinical use of PDT was restricted due to the 40 weak penetration in deep tissues and the non-specific damage to normal tissues.…”

Section: Introductionmentioning

confidence: 99%

In vivo targeted magnetic resonance imaging and visualized photodynamic therapy in deep-tissue cancers using folic acid-functionalized superparamagnetic-upconversion nanocomposites

et al. 2015

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Multifunctional nanoprobes used in magnetic resonance imaging (MRI) and photodynamic therapy (PDT) also have potential applications in diagnosis and visualized therapy of cancers, and hence it is important to investigate the active-targeting ability and in vivo reliability of these nanoprobes. In this work, folic acid (FA)-targeted, photosensitizer (PS)-loaded Fe3O4@NaYF4:Yb/Er (FA-NPs-PS) nanocomposites were synthesized for in vivo T2-weighted MRI and visualized PDT of cancers by modeling MCF-7 tumor-bearing nude mice. By measuring the upconversion luminescence (UCL) and fluorescence emission spectra, the as-prepared FA-NPs-PS nanocomposites showed near-infrared (NIR)-triggered PDT performance due to the production of a singlet oxygen species. Moreover, by tracing PS fluorescence in MCF-7, HeLa cells and in MCF-7 tumors, the FA-targeted nanocomposites demonstrated good targeting ability both in vitro and in vivo. Under the irradiation of a 980 nm laser, the viabilities of MCF-7 and HeLa cells incubated with FA-NPs-PS nanocomposites could decrease to about 18.4% and 30.7%, respectively, and the inhibition of MCF-7 tumors could reach about 94.9%. The transverse MR relaxivity of 63.79 mM(-1) s(-1) (r2 value) and in vivo MR imaging of MCF-7 tumors indicated an excellent T2-weighted MR performance. This work demonstrated that FA-targeted MRI/PDT nanoprobes are effective for in vivo diagnosis and visualized therapy of breast cancers.

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Section: Introductionmentioning

confidence: 99%

In vivo targeted magnetic resonance imaging and visualized photodynamic therapy in deep-tissue cancers using folic acid-functionalized superparamagnetic-upconversion nanocomposites

et al. 2015

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“…187,188 To date, light activation of TiO 2 NPs represents a major safety concern for nanotoxicology rather than a therapeutic opportunity, 185 although some reports exist. [189][190][191] Equivalent to common photosensitizers, QDs have also been proposed as intrinsic PDT agents. [192][193][194] However, the QYs of the singlet oxygen of QDs are very low compared to the ones of common photosensitizers (ca.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Pino¹

2014

J. Biomed. Opt

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Abstract. Continuous advances in the field of bionanotechnology, particularly in the areas of synthesis and functionalization of colloidal inorganic nanoparticles with novel physicochemical properties, allow the development of innovative and/or enhanced approaches for medical solutions. Many of the present and future applications of bionanotechnology rely on the ability of nanoparticles to efficiently interact with electromagnetic (EM) fields and subsequently to produce a response via scattering or absorption of the interacting field. The crosssections of nanoparticles are typically orders of magnitude larger than organic molecules, which provide the means for manipulating EM fields and, thereby, enable applications in therapy (e.g., photothermal therapy, hyperthermia, drug release, etc.), sensing (e.g., surface plasmon resonance, surface-enhanced Raman, energy transfer, etc.), and imaging (e.g., magnetic resonance, optoacoustic, photothermal, etc.). Herein, an overview of the most relevant parameters and promising applications of EM-active nanoparticles for applications in life science are discussed with a view toward tailoring the interaction of nanoparticles with EM fields. © The Authors.Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…Zeng used Fe 3 O 4 -TiO 2 nanocomposites as effective PSs, and showed darker contrast in T2-weighted MR images [48]. This facilitates the evaluation of tumor inhibition after the PDT-induced treatment and avoids the multiple drug intakes during the oncotherapy and image examination.…”

Section: Application Of Pdt In Os and Other Deep Cancer Modelsmentioning

confidence: 99%

A review and outlook in the treatment of osteosarcoma and other deep tumors with photodynamic therapy: from basic to deep

Zhu

Wang

et al. 2017

Oncotarget

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Photodynamic therapy, one of the most promising minimally invasive treatments, has received increasing focus in tumor therapy research, which has been widely applied in treating superficial tumors. Three basic factors - photosensitizer, the light source, and oxidative stress - are responsible for tumor cell cytotoxicity. However, due to insufficient luminous flux and peripheral tissue damage, the utilization of photodynamic therapy is facing a huge limitation in deep tumor therapy. Osteosarcoma is the typical deep tumor, which is the most commonly occurring malignancy in children and adolescents. Despite developments in surgery, high risks of the amputation still threatens the health of osteosarcoma patients. In this review, we summarize recent developments in the field of photodynamic therapy and specifically PDT research in OS treatment modalities. In addition, we also provide some novel suggestions, which could potentially be a breakthrough in PDT-induced OS therapies. PDT has the potential to become an effective therapy while the its limitations still present when applied on the treatment of OS or other types of deep tumors. Thus, more researches and studies in the field are required.

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Multifunctional Fe3O4–TiO2 nanocomposites for magnetic resonance imaging and potential photodynamic therapy

Cited by 115 publications

References 35 publications

In vivo targeted magnetic resonance imaging and visualized photodynamic therapy in deep-tissue cancers using folic acid-functionalized superparamagnetic-upconversion nanocomposites

In vivo targeted magnetic resonance imaging and visualized photodynamic therapy in deep-tissue cancers using folic acid-functionalized superparamagnetic-upconversion nanocomposites

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

A review and outlook in the treatment of osteosarcoma and other deep tumors with photodynamic therapy: from basic to deep

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