Multifunctional fluorescence/photoacoustic bimodal imaging of γ-glutamyltranspeptidase in liver disorders under different triggering conditions

Wang, Kai; Chen, Xu-Yang; Zhang, Ren-Wei-Yang; Yue, Ying; Wen, Xiao-Lin; Yang, Yu-Shun; Han, Chen-Yang; Ma, Yuan; Liu, Hong-Ji; Zhu, Hai-Liang

doi:10.1016/j.biomaterials.2024.122635

Biomaterials

2024

DOI: 10.1016/j.biomaterials.2024.122635

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Multifunctional fluorescence/photoacoustic bimodal imaging of γ-glutamyltranspeptidase in liver disorders under different triggering conditions

Kai Wang,

Xu-Yang Chen,

Ren-Wei-Yang Zhang

et al.

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2025

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Cited by 3 publications

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A novel near-infrared fluorescent probe with large Stokes shift for monitoring γ-glutamyltranspeptidase in tumor and liver injury mice

Wang,

Liu,

Tan

et al. 2025

Microchemical Journal

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A novel near-infrared fluorescent probe with large Stokes shift for monitoring γ-glutamyltranspeptidase in tumor and liver injury mice

Wang,

Liu,

Tan

et al. 2025

Microchemical Journal

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Zero-Crosstalk Tumor-Targeting Ratiometric Near-Infrared γ-Glutamyltranspeptidase Probe for Fluorescent-Guided Surgical Resection of Orthotopic Hepatic Tumor

Yang,

Wang

et al. 2025

Anal. Chem.

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The challenge of "false positive" signals significantly complicates tumor localization and surgical resection, which are pivotal for successful tumor surgeries. Therefore, the development of a method for preoperative tumor localization and intraoperative margin determination holds considerable promise for improving surgical outcomes. In this study, a zero-crosstalk ratiometric tumor-targeting near-infrared (NIR) fluorescent probe was developed for precise cancer diagnosis and intraoperative navigation via NIR fluorescence imaging. This probe integrates a tumor-targeting moiety that selectively homes in on hepatocellular carcinoma cells and exhibits a highly sensitive ratiometric response to γ-glutamyltranspeptidase (GGT), characterized by a substantial emission shift from 830 to 650 nm. This unique NIR ratiometric emission property significantly enhances its effectiveness in early diagnosis and imaging-guided surgery resection. Furthermore, this zero-crosstalk probe successfully monitors GGT activity in blood, cells, and in vivo, endowing its potential for early cancer diagnosis in the clinic. Due to its efficient targeting and sensitive in situ response to GGT in both subcutaneous tumors and orthotopic hepatic tumors, the probe exhibits accurate detection capability for hepatic tumors. Additionally, by leveraging zero-crosstalk ratiometric NIR fluorescence imaging, this tumor-targeting probe can serve as a sprayable tool for delineating tumor margins with precision, thereby furnishing real-time intraoperative imaging guidance during tumor resection surgery.

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Frontiers in fluorescence imaging: tools for the in situ sensing of disease biomarkers

Yang,

Hou,

2025

J. Mater. Chem. B

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Multifunctional fluorescence/photoacoustic bimodal imaging of γ-glutamyltranspeptidase in liver disorders under different triggering conditions

Cited by 3 publications

References 58 publications

A novel near-infrared fluorescent probe with large Stokes shift for monitoring γ-glutamyltranspeptidase in tumor and liver injury mice

A novel near-infrared fluorescent probe with large Stokes shift for monitoring γ-glutamyltranspeptidase in tumor and liver injury mice

Zero-Crosstalk Tumor-Targeting Ratiometric Near-Infrared γ-Glutamyltranspeptidase Probe for Fluorescent-Guided Surgical Resection of Orthotopic Hepatic Tumor

Frontiers in fluorescence imaging: tools for the in situ sensing of disease biomarkers

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