Multifunctional Gold Nanoparticle-Based Fluorescence Resonance Energy-Transfer Probe for Target Drug Delivery and Cell Fluorescence Imaging

Zhang, Qian; Gong, Yan; Guo, Xinjie; Zhang, Peng; Ding, Caifeng

doi:10.1021/acsami.8b12897

Cited by 51 publications

(32 citation statements)

References 39 publications

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“…As potential drug carriers, AuNPs have received considerable attention by many researchers [ 6 , 7 , 8 , 9 , 10 ], as it has been frequently reported that they can induce programmed cell death (i.e., apoptosis) [ 11 , 12 ]. Furthermore, as drug carriers, AuNPs can transport imaging and therapeutic agents, providing the possibility of diagnosis, treatment, and monitoring therapeutic progress, while AuNPs themselves do not participate in diagnosis or therapy [ 13 , 14 , 15 , 16 , 17 ]. However, AuNPs are rarely reported as agents that can inhibit cell proliferation and achieve both fluorescence-enhanced cell imaging and specific cell targeting.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid-Modified and Doxorubicin-Loaded Gold Nanoparticles and Evaluation of Their Bioactivity

Ren

Yang

et al. 2021

Pharmaceuticals

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Functionalized gold nanoparticles (AuNPs) have been successfully used in many fields as a result of having low cytotoxicity, good biocompatibility, excellent optical properties, and their ability to target cancer cells. Here, we synthesized AuNP carriers that were modified by hyaluronic acid (HA), polyethylene glycol (PEG), and adipic dihydrazide (ADH). The antitumor drug doxorubicin (Dox) was loaded into AuNP carriers and attached chemically. The Au nanocomposite AuNPs@MPA-PEG-HA-ADH-Dox was able to disperse uniformly in aqueous solution, with a diameter of 15 nm. The results of a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assay indicated that AuNP carriers displayed very little toxicity toward cells in high doses, although the antitumor properties of Au nanocomposites were significantly enhanced. Cellular uptake experiments demonstrated that AuNPs modified with hyaluronic acid were more readily ingested by HepG2 and HCT-116 cells, as they have a large number of CD44 receptors. A series of experiments measuring apoptosis such as Rh123 and annexin V-FITC staining, and analysis of mitochondrial membrane potential (MMP) analysis, indicated that apoptosis played a role in the inhibition of cell proliferation by AuNPs@MPA-PEG-HA-ADH-Dox. Excessive production of reactive oxygen species (ROS) was the principal mechanism by which the Au nanocomposites inhibited cell proliferation, leading to apoptosis. Thus, the Au nanocomposites, which allowed cell imaging in real-time and induced apoptosis in specific cell types, represent theragnostic agents with potential for future clinical applications in bowel cancer.

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Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid-Modified and Doxorubicin-Loaded Gold Nanoparticles and Evaluation of Their Bioactivity

Ren

Yang

et al. 2021

Pharmaceuticals

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“…Gold nanoparticles have been demonstrated to be a promising drug delivery scaffold because they are known to be biocompatible, [ 23,24 ] simple to synthesize, and can have functional surface moieties. [ 25–33 ] We have developed a functional gold nanoparticle that enables the selective, stepwise release of two distinct payloads by altering the wavelength of illumination ( Figure ). With this nanoparticle, we were able to achieve stepwise, wavelength selective, payload release from single nanoparticles in live cells, which has not been achieved with previously reported systems.…”

Section: Figurementioning

confidence: 99%

Wavelength‐Selective Light‐Controlled Stepwise Photolysis from Single Gold Nanoparticles

Zhou

Zhang

Lin

et al. 2020

Adv Healthcare Materials

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Light‐controlled sequential photolysis from a single nanoparticle is a challenge for controlled release. A wavelength‐selective sequential photolysis from single gold nanoparticles is reported for the first time. In particular, it is also demonstrated that such nanoparticle can be used to sequentially release two payloads in living cells. In principle, this system can be extended to sequential release of multiple different types of payloads by rational design of diverse photocleavable linkers. It is expected that this work can provide a new tool for better orderly controlling cellular events that request high spatiotemporal manners.

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“…To achieve targeted drug delivery for tumor diagnosis and treatment, reduce toxic and side effects on normal cells, and assist in fluorescence imaging to detect the GSH content, Ding et al . designed and prepared cysteine (CS)‐stabilized gold nanoparticles (CS‐AuNPs‐DOX fluorescent nanoprobe) [59] . The change of fluorescence signal of the drug loaded with the fluorescent probe was used to indicate the content of RTCs, so as to image the lesion, help diagnose the disease, and complete the targeted delivery of the drug.…”

Section: Biological Applications Related To Rtcsmentioning

confidence: 99%

Reduced Thiol Compounds – Induced Biosensing, Bioimaging Analysis and Targeted Delivery

et al. 2020

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Reduced thiol compounds (RTCs), such as glutathione (GSH), cysteine (Cys), and homocysteine (Hcy), are important components of many amino acids and proteins. They are also basic building blocks that make up organisms and play an important role in physiology and pathology. Therefore, based on the fundamental characteristics of RTCs in vivo, researchers have reported their use in biosensing and imaging analysis and as carriers in life sciences and health sciences. In this review, we will introduce the principles of RTCs and highlight their applications in biosensing and imaging analysis and as carriers reported from 2015 to 2020. Yingshu Guo (top left) obtained her Ph.D. degree from Qingdao University of Science and Technology in 2012. She is currently a professor at Linyi University, China, with research interests in bioanalytical chemistry and chemical biology. Xiaofei Zheng (top middle) obtained his B.S. degree from Linyi University in 2019. Then he pursued his M.S. degree under the supervision of Prof. Yingshu Guo at Linyi University. His current research is focused on bioanalytical chemistry. Xiuping Cao (top right) obtained her B.S. degree from Shandong University of Traditional Chinese Medicine in 2019. Then she pursued her M.S. degree under the supervision of Prof. Yingshu Guo at Linyi University. Her current research is focused on bioanalytical chemistry and chemical biology. Wenxin Li (bottom left) obtained her B.S. degree from Qilu Institute of Technology in 2020. Then she pursued her M.S. degree under the supervision of Prof. Yingshu Guo at Linyi University. Her current research is focused on bioanalytical chemistry and chemical biology. Di Wu (bottom middle) obtained her B.S. degree from Linyi University in 2020. Then she pursued her M.S. degree under the supervision of Prof. Yingshu Guo at Linyi University. Her current research is focused on bioanalytical chemistry. Shusheng Zhang (bottom right) obtained his Ph.D. degree from Nanjing University in 1999. He is a leading researcher at Linyi University with research interests in bioanalytical chemistry.

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Multifunctional Gold Nanoparticle-Based Fluorescence Resonance Energy-Transfer Probe for Target Drug Delivery and Cell Fluorescence Imaging

Cited by 51 publications

References 39 publications

Hyaluronic Acid-Modified and Doxorubicin-Loaded Gold Nanoparticles and Evaluation of Their Bioactivity

Hyaluronic Acid-Modified and Doxorubicin-Loaded Gold Nanoparticles and Evaluation of Their Bioactivity

Wavelength‐Selective Light‐Controlled Stepwise Photolysis from Single Gold Nanoparticles

Reduced Thiol Compounds – Induced Biosensing, Bioimaging Analysis and Targeted Delivery

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