Multifunctional GQDs for receptor targeting, drug delivery, and bioimaging in pancreatic cancer

Kumar Shukla, Monu; Parihar, Arpana; Karthikeyan, Chandrabose; Kumar, Deepak; Khan, Raju

doi:10.1039/d3nr03161f

Cited by 12 publications

(3 citation statements)

References 123 publications

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“…Recent investigations into receptor-selective drug delivery systems have demonstrated that targeting ligands can enhance the entry of nanoparticles into the target tissues through ligand-receptor binding, while safeguarding the active drug payload against non-specific delivery [27,28]. The targeting ligands enable nanoparticles to bind to cell surface receptors and enter cells through receptor-mediated endocytosis [29,30]. In our study, we sequentially coated the surface of PLGA-API-NPs with CS and HA.…”

Section: Discussionmentioning

confidence: 99%

HA-Coated PLGA Nanoparticles Loaded with Apigenin for Colon Cancer with High Expression of CD44

Yang,

Mao,

Zhang

et al. 2023

Molecules

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Apigenin (API) possesses excellent antitumor properties but its limited water solubility and low bioavailability restrict its therapeutic impact. Thus, a suitable delivery system is needed to overcome these limitations and improve the therapeutic efficiency. Poly (lactic-co-glycolic acid) (PLGA) is a copolymer extensively utilized in drug delivery. Hyaluronic acid (HA) is a major extracellular matrix component and can specifically bind to CD44 on colon cancer cells. Herein, we aimed to prepare receptor-selective HA-coated PLGA nanoparticles (HA-PLGA-API-NPs) for colon cancers with high expression of CD44; chitosan (CS) was introduced into the system as an intermediate, simultaneously binding HA and PLGA through electrostatic interaction to facilitate a tighter connection between them. API was encapsulated in PLGA to obtain PLGA-API-NPs, which were then sequentially coated with CS and HA to form HA-PLGA-API-NPs. HA-PLGA-API-NPs had a stronger sustained-release capability. The cellular uptake of HA-PLGA-API-NPs was enhanced in HT-29 cells with high expression of CD44. In vivo, HA-PLGA-API-NPs showed enhanced targeting specificity towards the HT-29 ectopic tumor model in nude mice in comparison with PLGA-API-NPs. Overall, HA-PLGA-API-NPs were an effective drug delivery platform for API in the treatment of colon cancers with high expression of CD44.

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Section: Discussionmentioning

confidence: 99%

HA-Coated PLGA Nanoparticles Loaded with Apigenin for Colon Cancer with High Expression of CD44

Yang,

Mao,

Zhang

et al. 2023

Molecules

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“…One approach is to use nanoparticles to deliver chemotherapy drugs specifically to pancreatic cancer cells 5 . This technique has the potential to decrease the adverse effects associated with traditional chemotherapy by selectively targeting cancer cells and avoiding healthy cells.…”

Section: Introductionmentioning

confidence: 99%

In vitro photothermal therapy of pancreatic cancer mediated by immunoglobulin G-functionalized silver nanoparticles

Nedelcu,

Mocan,

Sabau

et al. 2024

Sci Rep

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Pancreatic cancer is one of the most aggressive forms of cancer, and treatment options are limited. One therapeutic approach is to use nanoparticles to deliver the active agent directly to pancreatic cancer cells. Nanoparticles can be designed to specifically target cancer cells, minimizing damage to healthy tissues. Silver nanoparticles have the unique ability to absorb light, especially in the near-infrared (NIR) region. In this study, silver nanoparticles functionalized with IgG molecules were synthesized and administered to pancreatic cancer cell lines. Subsequently, the cells were photo-excited using a 2 W 808 nm laser and further examined in PANC-1 pancreatic cancer cell lines. Flow cytometry and confocal microscopy combined with immunochemical staining were used to examine the interaction between photo-excited silver nanoparticles and pancreatic cancer cells. The photothermal therapy based on IgG-functionalized silver nanoparticles in pancreatic cancer induces dysfunction in the Golgi apparatus, leading to the activation of the caspase-3 apoptotic pathway and ultimately resulting in cellular apoptosis. These findings suggest that our proposed IgG nanoparticle laser treatment could emerge as a novel approach for the therapy of pancreatic cancer.

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“…The rapid evolution of nanotechnology has facilitated the evolution of various types of functional nano systems that may enable the precise diagnosis and treating of pancreatic carcinoma. − In particular, multifunctional nanosystems that integrate drug delivery and imaging functions can achieve precise positioning and controlled drug release at the tumor site, thereby maximizing the therapeutic potential of anticancer drugs while reducing damage to normal tissues. This is considered to be an effective method of achieving precision treatment of pancreatic cancer. Currently, various functional nano systems that have been designed to treat pancreatic cancer have shown good results. − However, many of these nano systems can release drugs prematurely and have problems such as fast elimination in vivo, which can limit the therapeutic effect .…”

Section: Introductionmentioning

confidence: 99%

A pH-Responsive Nanoplatform Based on Magnetic Mesoporous Silica Nanoparticles for Enhanced Treatment of Pancreatic Cancer

Qi,

Wang,

Yin

et al. 2023

ACS Appl. Nano Mater.

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Multifunctional GQDs for receptor targeting, drug delivery, and bioimaging in pancreatic cancer

Abstract: Pancreatic cancer is a devastating disease with a low survival rate and limited treatment options. Graphene quantum dots (GQDs) have recently become popular as a promising platform for cancer diagnosis...

Cited by 12 publications

References 123 publications

HA-Coated PLGA Nanoparticles Loaded with Apigenin for Colon Cancer with High Expression of CD44

HA-Coated PLGA Nanoparticles Loaded with Apigenin for Colon Cancer with High Expression of CD44

In vitro photothermal therapy of pancreatic cancer mediated by immunoglobulin G-functionalized silver nanoparticles

A pH-Responsive Nanoplatform Based on Magnetic Mesoporous Silica Nanoparticles for Enhanced Treatment of Pancreatic Cancer

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