Multifunctional hybrid nanosystems based on mesoporous silica and hydroxyapatite nanoparticles applied as potential nanocarriers for theranostic applications

Apostolos, Rafaela Caroline Rodrigues dos; Cipreste, Marcelo Fernandes; Sousa, Ricardo Geraldo de; Sousa, Edésia Martins Barros de

doi:10.1007/s11051-020-05105-0

Cited by 18 publications

(27 citation statements)

References 75 publications

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“…It is well known that multifunctional nanoparticles based on silica and hydroxyapatite containing stimuli‐responsive polymers seem to be a promising material for use in biomedical applications. This material showed synergistic effects for bone regeneration, controlled drug delivery, and diagnosis (dos Apostolos, Cipreste, de Sousa, & de Sousa, 2020).…”

Section: Discussionmentioning

confidence: 99%

Biocompatibility of mesoporous SBA‐16/hydroxyapatite nanocomposite and dentin demineralized particles on human dental pulp stem cells

Bulajić

Drljača

Čapo

et al. 2021

Microscopy Res & Technique

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In the present work, a biomaterial (SBA-16/HA) based on the growth of hydroxyapatite (HA) particles within an organized silica structure SBA-16 (Santa Barbara Amorphous-16) was developed to evaluate its application to act as a porous microenvironment promoting attachment and viability of human dental pulp stem cells of healthy deciduous teeth (SHED). First, SHED were isolated and their phenotypes were evaluated by flow cytometry. The samples of SBA-16/HA were characterized by X-ray diffraction (XRD), small and wide angle X-ray scattering (SWAXS), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) equipped with energy dispersive spectra detector (EDS). Afterward, cells were cultured in the eluates of the above-mentioned biomaterial aged for 24 hr, 7. and 14 days. Bio-Oss ® and dentin particles are involved for comparison and cells are cultured in the eluates of these two materials also. Thiazolyl Blue Tetrazolium bromide assay-MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide assay) was used for the determination of cell viability. The results obtained by all aforementioned characterization methods of SBA-16/HA, revealed a uniform spherical mesoporous structure, an intrinsic characteristic of this material. This material displayed excellent biocompatibility on SHEDs, and even proliferative potential, indicating that SBA-16/HA could potentially serve as a suitable substrate for bone regeneration.Contrary to SBA-16/HA, dentin particles showed low cytotoxicity at all time points, compared to control and Bio-Oss ® groups. Our results substantiate the idea that SBA-16/HA has a beneficial effect on SHEDs, thus paving the way toward developing new material for bone replacement.

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Section: Discussionmentioning

confidence: 99%

Biocompatibility of mesoporous SBA‐16/hydroxyapatite nanocomposite and dentin demineralized particles on human dental pulp stem cells

Bulajić

Drljača

Čapo

et al. 2021

Microscopy Res & Technique

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“…At physiological pH, a rapid release of MTX during the first 2 h was evidenced, reaching 63% of the loaded drug. A constant release followed this stage after 6 h. At pH 5, a trapping of MTX was registered, with only 0.5% of the pharmaceutical agent released during the first 2 h and 4% at around 16 h. This result demonstrated that even though the nanocomposite showed good drug loading efficiency, the delivery system was not adequate for cancer treatment due to the electrostatic interactions between the antitumoral agent and the components of the composite [ 153 ].…”

Section: Biomedical Applications Of Lanthanides-substituted Hapmentioning

confidence: 99%

Lanthanides-Substituted Hydroxyapatite for Biomedical Applications

Lama-Odría

Valle

Puiggalı́

2023

IJMS

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Lately, there has been an increasing demand for materials that could improve tissue regenerative therapies and provide antimicrobial effects. Similarly, there is a growing need to develop or modify biomaterials for the diagnosis and treatment of different pathologies. In this scenario, hydroxyapatite (HAp) appears as a bioceramic with extended functionalities. Nevertheless, there are certain disadvantages related to the mechanical properties and lack of antimicrobial capacity. To circumvent them, the doping of HAp with a variety of cationic ions is emerging as a good alterative due to the different biological roles of each ion. Among many elements, lanthanides are understudied despite their great potential in the biomedical field. For this reason, the present review focuses on the biological benefits of lanthanides and how their incorporation into HAp can alter its morphology and physical properties. A comprehensive section of the applications of lanthanides-substituted HAp nanoparticles (HAp NPs) is presented to unveil the potential biomedical uses of these systems. Finally, the need to study the tolerable and non-toxic percentages of substitution with these elements is highlighted.

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“…Each approach gives rise to varying morphology and luminescent properties as can be seen in Table 2 . Moreover, nHA can be hybridized with other biocompatible materials and polymers to produce versatile drug delivery platforms [103] , [104] , [105] , [106] . However, to synthesize luminescent material based on nHA the most widely used synthesis techniques are precipitation and hydrothermal.…”

Section: Luminescent Materials Based On Hydroxyapatitementioning

confidence: 99%

Progress on carbon dots and hydroxyapatite based biocompatible luminescent nanomaterials for cancer theranostics

Sengar¹,

Chauhan²,

Hirata³

2022

Translational Oncology

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Multifunctional hybrid nanosystems based on mesoporous silica and hydroxyapatite nanoparticles applied as potential nanocarriers for theranostic applications

Cited by 18 publications

References 75 publications

Biocompatibility of mesoporous SBA‐16/hydroxyapatite nanocomposite and dentin demineralized particles on human dental pulp stem cells

Biocompatibility of mesoporous SBA‐16/hydroxyapatite nanocomposite and dentin demineralized particles on human dental pulp stem cells

Lanthanides-Substituted Hydroxyapatite for Biomedical Applications

Progress on carbon dots and hydroxyapatite based biocompatible luminescent nanomaterials for cancer theranostics

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