Multifunctional hydrogels based on chitosan, hyaluronic acid and other biological macromolecules for the treatment of inflammatory bowel disease: A review

Ouyang, Yongliang; Zhao, Jiulong; Wang, Shige

doi:10.1016/j.ijbiomac.2022.12.032

Cited by 77 publications

(18 citation statements)

References 179 publications

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“…Cellulose is a polysaccharide consisting of linear chains of β(1→4) linked D-glucose units with a large number of hydroxyl groups in the backbone, resulting in a cellulose-based hydrogel with excellent structural stability [82][83] . The limitations of natural cellulose applications are mainly due to its insolubility in common solvents, caused by inter-and intra-molecular hydrogen bonding and van der Waals forces [84] .…”

Section: Other Biomassesmentioning

confidence: 99%

Preparation and Application of Biomass-based Sprayable Hydrogels

Tan¹,

Cai²,

Li³

et al. 2023

Paper and Biomaterials

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Hydrogels have three-dimensional network structures that have been widely applied owing to their high water content, excellent biocompatibility, and physicochemical properties. Compared with conventional hydrogels, sprayable hydrogels exhibit excellent temporal and spatial controllability. Biomass materials offer easy accessibility, biocompatibility, biodegradability, and other physicochemical properties that are extensively used in the formation of sprayable hydrogels. In situ formed biomass-based sprayable hydrogels are realized by chemical or physical crosslinking. Rapid spray filming, in situ drug delivery, high permeability, and flexible portability enable biomass-based sprayable hydrogels to show great potential for topical drug delivery, wound healing, and other applications. This review describes in detail the status of research on the preparation and application of biomassbased sprayable hydrogels and suggests prospects for their future development.

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Section: Other Biomassesmentioning

confidence: 99%

Preparation and Application of Biomass-based Sprayable Hydrogels

Tan¹,

Cai²,

Li³

et al. 2023

Paper and Biomaterials

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Section: Application Of Bioactive Nanomaterials In Inflammatory Diseasesmentioning

confidence: 99%

“…Hydrogels used to treat IBD are made of natural polymers such as chitosan ( Xu et al, 2017 ), alginate ( Cheng et al, 2022 ), hyaluronic acid ( Liu et al, 2021 ), and dextran ( Pitarresi et al, 2007 ) as well as proteins such as chondroitin sulfate ( Zhang et al, 2019 ) and gelatin ( Zhang et al, 2021c ). A recent review ( Ouyang et al, 2022 ) summarized relevant reports on the types of hydrogels used to load drugs, peptides, and proteins and immunomodulators, as well as probiotics, and found that hydrogel carriers have excellent physical and chemical properties and are well used in IBD treatment. In addition, phosphorus- based dendrimer-based molecules can inhibit the maturation of pro-inflammatory CD4 + T lymphocytes and dendritic cells (DC), Poly (ε-caprolactone)—β- poly (ethylenimine) (PCL—β- PEI) nanofibers can inhibit the secretion of cytokines α, tumor necrosis factor α (TNF- α) and interferon- γ (Ifn- γ) by dendritic cells and macrophages stimulated by CpG oligodeoxynucleotides (ODNs) through electrostatic adsorption.…”

Section: Application Of Bioactive Nanomaterials In Biomedicinementioning

confidence: 99%

Advanced bioactive nanomaterials for diagnosis and treatment of major chronic diseases

Liu

Yi²,

Zhong³

et al. 2023

Front. Mol. Biosci.

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With the rapid innovation of nanoscience and technology, nanomaterials have also been deeply applied in the medical and health industry and become one of the innovative methods to treat many diseases. In recent years, bioactive nanomaterials have attracted extensive attention and have made some progress in the treatment of some major chronic diseases, such as nervous system diseases and various malignant tumors. Bioactive nanomaterials depend on their physical and chemical properties (crystal structure, surface charge, surface functional groups, morphology, and size, etc.) and direct produce biological activity and play to the role of the treatment of diseases, compared with the traditional nanometer pharmaceutical preparations, biological active nano materials don’t exert effects through drug release, way more directly, also is expected to be more effective for the treatment of diseases. However, further studies are needed in the evaluation of biological effects, fate in vivo, structure-activity relationship and clinical transformation of bionanomaterials. Based on the latest research reports, this paper reviews the application of bioactive nanomaterials in the diagnosis and treatment of major chronic diseases and analyzes the technical challenges and key scientific issues faced by bioactive nanomaterials in the diagnosis and treatment of diseases, to provide suggestions for the future development of this field.

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“…In the case of natural polysaccharides, which are frequently used as the raw materials for the preparation of the hydrogels, their relevant characteristics, such as abundant sources, biodegradation, good biocompatibility, and easy modification, ensure the effective hemostasis and subsequent wound healing [ 19 , 20 ]. An ideal polymer hydrogel for hemostasis is expected to have the following features [ 21 , 22 ]: (1) it should have a rapid gelation rate to stop bleeding instantly and facilitate active wound healing; (2) in dynamic and humid environments, the hemostatic hydrogel should have sufficient adhesion and outstanding mechanical properties to seal the wound and avoid the migration of the hemostatic hydrogel from the bleeding site; and (3) it should have good biocompatibility. In addition, controllable swelling behaviors are necessary, since highly swollen hydrogels may cause the compression of the surrounding tissue.…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects

et al. 2023

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The design of new hemostatic materials to mitigate uncontrolled bleeding in emergencies is challenging. Chitosan-based hemostatic hydrogels have frequently been used for hemostasis due to their unique biocompatibility, tunable mechanical properties, injectability, and ease of handling. Moreover, chitosan (CS) absorbs red blood cells and activates platelets to promote hemostasis. Benefiting from these desired properties, the hemostatic application of CS hydrogels is attracting ever-increasing research attention. This paper reviews the recent research progress of CS-based hemostatic hydrogels and their advantageous characteristics compared to traditional hemostatic materials. The effects of the hemostatic mechanism, effects of deacetylation degree, relative molecular mass, and chemical modification on the hemostatic performance of CS hydrogels are summarized. Meanwhile, some typical applications of CS hydrogels are introduced to provide references for the preparation of efficient hemostatic hydrogels. Finally, the future perspectives of CS-based hemostatic hydrogels are presented.

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Multifunctional hydrogels based on chitosan, hyaluronic acid and other biological macromolecules for the treatment of inflammatory bowel disease: A review

Cited by 77 publications

References 179 publications

Preparation and Application of Biomass-based Sprayable Hydrogels

Preparation and Application of Biomass-based Sprayable Hydrogels

Advanced bioactive nanomaterials for diagnosis and treatment of major chronic diseases

Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects

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