Multifunctional Hydrogels with Temperature, Ion, and Magnetocaloric Stimuli‐Responsive Performances

Wang, Xiaoqiao; Yang, Shengyang; Wang, Cai‐Feng; Chen, Li; Chen, Su

doi:10.1002/marc.201500748

Cited by 43 publications

(33 citation statements)

References 55 publications

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“…However, limitations resulting from chemical cross‐linking still twine in this kind of hydrogel due to the intrinsic irreversibility of covalent bonding. When subjected from internal or external stimuli, the network structure of this material can readily deteriorate and hardly recover to their original state. Besides, the introduction of toxic initiator or cross‐linker during the hydrogel preparation will impede the subsequent application in biomedical territory.…”

Section: Introductionmentioning

confidence: 99%

An Injectable Hydrogel with Excellent Self‐Healing Property Based on Quadruple Hydrogen Bonding

Zhang

Ngai

Deng

et al. 2016

Macro Chemistry & Physics

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Injectable polymeric hydrogels with self‐healing property are extremely appealing in biomedical applications for the reason that they could be transplanted via direct injection, which causes minimal invasion to human body. This work presents a novel injectable hydrogel based on strong interaction of quadruple hydrogen bonding from ureido pyrimidinone (UPy) moieties. A new monomer ureido pyrimidinone‐diisocyanate‐2‐hydroxyethyl‐methylene acrylic ester (named UPy‐NMA) carrying UPy moiety is synthesized for the first time and copolymerized with acrylamide to prepare hydrogel copolymer (PAU). The hydrogel is prepared by dissolving corresponding copolymer into deionized water under certain conditions. Mechanical property of prepared hydrogel is measured by rheometer and the results show that the developed hydrogel display excellent self‐healing ability as well as outstanding injectable property. In addition, adequate pore size of hydrogels from scanning electron microscopy also hints that the fabricated hydrogel can provide an intriguing glimpse for potential applications of tissue engineering.

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Section: Introductionmentioning

confidence: 99%

An Injectable Hydrogel with Excellent Self‐Healing Property Based on Quadruple Hydrogen Bonding

Zhang

Ngai

Deng

et al. 2016

Macro Chemistry & Physics

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“…Gelation is required to form cell‐laden structures or to culture cells on the surface of hydrogels. Some hydrogels receive external stimuli as signals and respond by changing the structure of polymer chains . These hydrogels can be categorized as stimuli‐responsive hydrogels because they undergo physicochemical changes upon exposure to external stimuli.…”

Section: Gelation Methods Of Hydrogelsmentioning

confidence: 99%

“…Some hydrogels receive external stimuli as signals and respond by changing the structure of polymer chains. 77 These hydrogels can be categorized as stimuli-responsive hydrogels because they undergo physicochemical changes upon exposure to external stimuli. Various stimuli can be used to form gel structures between each polymer chain.…”

Section: Gelation Methods Of Hydrogelsmentioning

confidence: 99%

Hydrogel‐based three‐dimensional cell culture for organ‐on‐a‐chip applications

Lee

Shim

Kim

et al. 2017

Biotechnology Progress

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Recent studies have reported that three-dimensionally cultured cells have more physiologically relevant functions than two-dimensionally cultured cells. Cells are three-dimensionally surrounded by the extracellular matrix (ECM) in complex in vivo microenvironments and interact with the ECM and neighboring cells. Therefore, replicating the ECM environment is key to the successful cell culture models. Various natural and synthetic hydrogels have been used to mimic ECM environments based on their physical, chemical, and biological characteristics, such as biocompatibility, biodegradability, and biochemical functional groups. Because of these characteristics, hydrogels have been combined with microtechnologies and used in organ-on-a-chip applications to more closely recapitulate the in vivo microenvironment. Therefore, appropriate hydrogels should be selected depending on the cell types and applications. The porosity of the selected hydrogel should be controlled to facilitate the movement of nutrients and oxygen. In this review, we describe various types of hydrogels, external stimulation-based gelation of hydrogels, and control of their porosity. Then, we introduce applications of hydrogels for organ-on-a-chip. Last, we also discuss the challenges of hydrogel-based three-dimensional cell culture techniques and propose future directions. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 33:580-589, 2017.

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“…Moreover thermoresponsive polymers loaded with superparamagnetic nanoparticles can change phase upon magnetic stimulation and can be used for drug release [47][48][49]. In this work we developed magnetic hydrogel substrates and then performed AMF heating measures at room temperature to assess the dependence of magnetic field intensity, frequency and iron concentration on the hydrogel temperature increase.…”

Section: Amf Heating and Dynamic Phase Changementioning

confidence: 99%

Dynamic and biocompatible thermo-responsive magnetic hydrogels that respond to an alternating magnetic field

Crippa

Moore

Mortato

et al. 2017

Journal of Magnetism and Magnetic Materials

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Magnetic thermo-responsive hydrogels are a new class of materials that have recently attracted interest in biomedicine due to their ability to change phase upon magnetic stimulation. They have been used for drug release, magnetic hyperthermia treatment, and can potentially be engineered as stimuli-responsive substrates for cell mechanobiology. In this regard, we propose a series of magnetic thermo-responsive nanocomposite substrates that undergo cyclical swelling and de-swelling phases when actuated by an alternating magnetic field in aqueous environment. The synthetized substrates are obtained with a facile and reproducible method from poly-N-isopropylacrylamide and superparamagnetic iron oxide nanoparticles. Their conformation and the temperature-related, magnetic, and biological behaviors were characterized via scanning electron microscopy, swelling ratio analysis, vibrating sample magnetometry, alternating magnetic field stimulation and indirect viability assays. The nanocomposites showed no cytotoxicity with fibroblast cells, and exhibited swelling/deswelling behavior near physiological temperatures (around 34°C). Therefore these magnetic thermo-responsive hydrogels are promising materials as stimuli-responsive substrates allowing the study of cell-behavior by changing the hydrogel properties in situ.

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Multifunctional Hydrogels with Temperature, Ion, and Magnetocaloric Stimuli‐Responsive Performances

Cited by 43 publications

References 55 publications

An Injectable Hydrogel with Excellent Self‐Healing Property Based on Quadruple Hydrogen Bonding

An Injectable Hydrogel with Excellent Self‐Healing Property Based on Quadruple Hydrogen Bonding

Hydrogel‐based three‐dimensional cell culture for organ‐on‐a‐chip applications

Dynamic and biocompatible thermo-responsive magnetic hydrogels that respond to an alternating magnetic field

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