2014
DOI: 10.1021/bm5006257
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Multifunctional Interpenetrating Polymer Network Hydrogels Based on Methacrylated Alginate for the Delivery of Small Molecule Drugs and Sustained Release of Protein

Abstract: Multifunctional injectable thermo-/pH-responsive hydrogels as release systems for the oral delivery of small molecule drugs and the local delivery of protein are presented. The injectable interpenetrating polymer network (IPN) hydrogels based on poly(ethylene glycol) methacrylate, N-isopropylacrylamide, and methacrylated alginate were prepared by using ammonium persulfate (APS) and N,N,N',N'-tetramethylethylenediamine (TEMED) as a redox initiator system at body temperature, and the obtained hydrogels overcame … Show more

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Cited by 146 publications
(94 citation statements)
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“…The isolation and expansion of the rabbit adipose-derived mesenchymal stem cells (ADMSCs) was performed following our previous report [57]. The ADMSCs and C2C12 cells proliferation when contacted with the hydrogels surface was measured by employing a direct contact test between hydrogels and cells [58,59].…”
Section: In Vitro Cell Culturementioning
confidence: 99%
“…The isolation and expansion of the rabbit adipose-derived mesenchymal stem cells (ADMSCs) was performed following our previous report [57]. The ADMSCs and C2C12 cells proliferation when contacted with the hydrogels surface was measured by employing a direct contact test between hydrogels and cells [58,59].…”
Section: In Vitro Cell Culturementioning
confidence: 99%
“…Protein encapsulation offers the opportunity to isolate and manipulate the function and structure of proteins. [45] Encapsulation within hydrogels presents materials that may be readily applied to the fields of tissue engineering, [46] protein therapeutics, [47] and nutrient delivery. [48] Consequently, biodegradable, noncytotoxic hydrogel materials that may be produced, and further modified, in a facile manner are highly sought.…”
Section: Protein Encapsulation By Chitosan-based Hydrogelsmentioning
confidence: 99%
“…However, when conjugated to albumin the release was significantly reduced to about 50% over 42 days, this is probably because the pore distribution in the hydrogel solution, hinder the free diffusion of the high molecular weight BSA molecule. We hypothesized the conjugation to a large molecule will help slow the diffusion out of the hydrogel based on previous literature showing fast release of small drugs compared to slow release of high molecular weight BSA molecules from the same hydrogel delivery system 32 . When FITC was conjugated to albumin and encapsulated in alginate microparticles the release of fluorescein was completely blocked up to 42 days, probably also affected by the attractions between carboxyl groups (−COOH) on the alginate chain and the amine group (−NH 2 ) of BSA, as well as, the hydrogen bonds between the −COOH from alginate and −COOH from BSA, all restrict BSA release from the microparticle dispersed in the hydrogel 32 .…”
Section: Discussionmentioning
confidence: 99%