Multifunctional low-temperature photothermal nanodrug with in vivo clearance, ROS-Scavenging and anti-inflammatory abilities

Yang, Ganggang; Zhou, Dian-Yuan; Zhang, Pan; Yang, Jing; Zhang, Dongyang; Cao, Qian; Ji, Liang‐Nian; Mao, Zong‐Wan

doi:10.1016/j.biomaterials.2019.119280

Cited by 96 publications

(55 citation statements)

References 45 publications

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“…Fortunately, the decrease of ATP generation resulted from the consumption of Glu would ultimately down-regulate HSPs expression. [112] Therefore, combining GOx with magnetic NPs will be an effective way to achieve enhanced MHT. Further combining enhanced MHT with CDT would further achieve synergistic enhancement of cancer therapy.…”

Section: Magnetic Hyperthermia Therapy (Mht)mentioning

confidence: 99%

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

Jiang

et al. 2021

Adv Funct Materials

283

158

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Triggered by the endogenous chemical energy in the tumor microenvironment (TME), chemodynamic therapy (CDT) as an emerging non-exogenous stimulant therapeutic modality has received increasing attention in recent years. The chemodynamic agents can convert internal hydrogen peroxide (H 2 O 2 ) into the lethal reactive oxygen species (ROS) hydroxyl radicals ( • OH) for oncotherapy. Compared with other therapeutic modalities, CDT possesses many notable advantages, such as tumor-specific, highly selective, fewer systemic side effects, and no need for external stimulation. Nevertheless, mild acid pH, low H 2 O 2 content, and overexpressed reducing substance in TME severely suppressed the CDT efficiency. With the rapid development of nanotechnology, some kinds of nanomaterials have been utilized with improved CDT efficiency. In particular, the excellent photo-, ultrasound-, magnetic-, and other stimuli-response properties of nanomaterials make it possible for combination cancer therapy of CDT with other therapeutic modalities, and it has shown superior anti-cancer activity than monotherapies. Therefore, it is necessary to summarize the application of nanomaterial-based chemodynamic cancer therapy. In this review, the various nanomaterials-based nanoplatforms for CDT and its combinational therapies are summarized and discussed, aiming to provide inspiration for the design of better-quality agents to promote the CDT development and lay the foundation for its future conversion to clinical applications.

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Section: Magnetic Hyperthermia Therapy (Mht)mentioning

confidence: 99%

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

Jiang

et al. 2021

Adv Funct Materials

283

158

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“…Besides GA, there are many other small-molecule HSP inhibitors that have been employed in low-temperature PTT for achieving satisfactory cancer treatment outcomes. For example, Yang et al employed quercetin (Qu) as a multifunctional element to connect with ferrous iron (Fe II ) and polyvinylpyrrolidone (PVP) via coordination interaction to prepare nanodrugs (denoted as Qu-Fe II Ps) [ 99 ]. Qu had several important roles in this nanosystem: First, it is an inhibitor of HSP70 for realizing mild hyperthermia under NIR light irradiation [ 100 ].…”

Section: Applications Of Low-temperature Pttmentioning

confidence: 99%

“…Qu had several important roles in this nanosystem: First, it is an inhibitor of HSP70 for realizing mild hyperthermia under NIR light irradiation [ 100 ]. Second, since quercetin possesses good ROS-scavenging ability, the Qu-Fe II Ps could clear excessive ROS which might endanger surrounding healthy tissues, and reduce ROS-induced inflammatory cytokines to avoid unexpected inflammation [ 99 ]. Meanwhile, the coordination between Qu and Fe II became loose when Qu was oxidized by ROS, and subsequently Qu-Fe II Ps were disassembled into ultrasmall NPs ( Figure 3(c) ), which led to rapid renal clearance of the NPs to minimize acute or chronic toxicity.…”

Section: Applications Of Low-temperature Pttmentioning

confidence: 99%

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Low-Temperature Photothermal Therapy: Strategies and Applications

Duan

2021

Research

150

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Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in the biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells to develop thermal resistance, and thus, the efficacy of PTT may be dramatically decreased. In the meantime, the uncontrollable diffusion of heat can pose a threat to the surrounding healthy tissues. Recently, low-temperature PTT (also known as mild PTT or mild-temperature PTT) has demonstrated its remarkable capacity of conquering these obstacles and has shown excellent performance in bacterial elimination, wound healing, and cancer treatments. Herein, we summarize the recently proposed strategies for achieving low-temperature PTT based on nanomaterials and introduce the synthesis, characteristics, and applications of these nanoplatforms. Additionally, the combination of PTT and other therapeutic modalities for defeating cancers and the synergistic cancer therapeutic effect of the combined treatments are discussed. Finally, the current limitations and future directions are proposed for inspiring more researchers to make contributions to promoting low-temperature PTT toward more successful preclinical and clinical disease treatments.

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“…As ROS is produced by the Fe 2+ ‐induced Fenton reaction, the intracellular ROS content can increase when the Fe 2+ content is excessive, resulting in apoptosis of cancer cells, known as ferroptosis. [ 43 , 120 ] To date, Fe 2+/3+ ions have been widely studied as catalysts of the Fenton reaction in CDT, in which Fenton reagents react with endogenous H 2 O 2 to convert H 2 O 2 into hydroxyl radicals (·OH) in the TME to kill tumor cells. [ 41 , 121 ] The tumor‐suppressing effects of the Fenton reactions have inspired novel approaches for efficacious tumor therapy by introducing exogenous Fe 2+/3+ ions.…”

Section: Metal‐coordinated Supramolecular Self‐assemblies For Cancer Theranosticsmentioning

confidence: 99%

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

Wang

Jin

et al. 2021

Advanced Science

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Metal‐coordinated supramolecular nanoassemblies have recently attracted extensive attention as materials for cancer theranostics. Owing to their unique physicochemical properties, metal‐coordinated supramolecular self‐assemblies can bridge the boundary between traditional inorganic and organic materials. By tailoring the structural components of the metal ions and binding ligands, numerous multifunctional theranostic nanomedicines can be constructed. Metal‐coordinated supramolecular nanoassemblies can modulate the tumor microenvironment (TME), thus facilitating the development of TME‐responsive nanomedicines. More importantly, TME‐responsive organic–inorganic hybrid nanomaterials can be constructed in vivo by exploiting the metal‐coordinated self‐assembly of a variety of functional ligands, which is a promising strategy for enhancing the tumor accumulation of theranostic molecules. In this review, recent advancements in the design and fabrication of metal‐coordinated supramolecular nanomedicines for cancer theranostics are highlighted. These supramolecular compounds are classified according to the order in which the coordinated metal ions appear in the periodic table. Furthermore, the prospects and challenges of metal‐coordinated supramolecular self‐assemblies for both technical advances and clinical translation are discussed. In particular, the superiority of TME‐responsive nanomedicines for in vivo coordinated self‐assembly is elaborated, with an emphasis on strategies that enhance the accumulation of functional components in tumors for an ideal theranostic outcome.

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Multifunctional low-temperature photothermal nanodrug with in vivo clearance, ROS-Scavenging and anti-inflammatory abilities

Cited by 96 publications

References 45 publications

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

Low-Temperature Photothermal Therapy: Strategies and Applications

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

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