Multifunctional magnetic nanostructured hardystonite scaffold for hyperthermia, drug delivery and tissue engineering applications

Farzin, Ali; Fathi, Mohammadhossein; Emadi, Rahmatollah

doi:10.1016/j.msec.2016.08.060

Cited by 72 publications

(46 citation statements)

References 37 publications

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“…Farzin et al. prepared a multifunctional magnetic Hardstonite (HT) scaffold which aimed at regeneration of large‐bone defects caused by malignant bone tumors through a combination of hyperthermia, local drug delivery and osteoconductivity …”

Section: Magnetic‐based Drug Delivery For Bone Growthmentioning

confidence: 99%

“…Farzin et al prepared a multifunctional magnetic Hardstonite (HT) scaffold which aimed at regeneration of large-bone defects caused by malignant bone tumors through a combination of hyperthermia, local drug delivery and osteoconductivity. [61] 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 Drugs can be carried by IONPs-based composites to treat bone regeneration related diseases. Implant-associated infection is a serious problem in orthopedic surgery.…”

Section: Magnetic-based Drug Delivery For Bone Growthmentioning

confidence: 99%

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Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

et al. 2018

ChemPhysChem

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The paper provides a brief overview of the use of iron oxide nanoparticles (IONPs) in the areas of bone regenerative medicine. Reconstruction of bone defects caused by trauma, non-union, and bone tumor excision, still faces many challenges despite the intense investigations and advancement in bone-tissue engineering and bone regeneration over the past decades. IONPs have promising prospects in this field due to their controlled responsive characteristics in specific external magnetic fields and have been of great interest during the last few years. This Minireview aims to summarize the relevant progress and describes the following five aspects: (i) The general introduction of IONPs, with a focus on the magnetic properties as the base of application; (ii) using IONPs as tools to study and control stem cells for better treatment efficacy in stem-cell-based bone defect repair; (iii) the use of IONPs and their complexes in the delivery of therapeutic agents, including chemical drug molecules, growth factors, and genetic materials, to promote osteogenesis-related cell function and differentiation, healthy bone tissue growth, and functional reconstruction; (iv) magneto-mechanical actuation in the regulation of cells distribution, mechano-transduction membrane receptors activation, and mechanosensitive signaling pathways regulation, and (v) fabrication, characteristics, and in vitro and in vivo osteogenic effects of magnetic composite bone scaffolds. Ongoing prospects are also discussed.

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Section: Magnetic‐based Drug Delivery For Bone Growthmentioning

confidence: 99%

Section: Magnetic-based Drug Delivery For Bone Growthmentioning

confidence: 99%

Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

et al. 2018

ChemPhysChem

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“…2 Internal stimuli include pH and redox and high levels of certain enzymes, 3,4 while external stimuli include hyperthermia and magnetic field. [5][6][7][8] In some cases, the internal stimulus combined with the external stimulus will more effectively fine-tune their response to each stimulus and control the drug release more precisely. 9 However, it still remains a great challenge to develop an intelligent controlled-release system which can diagnose the tumor lesion site and realize precise control release at the tumor site.…”

Section: Introductionmentioning

confidence: 99%

Construction and application of a liver cancer-targeting drug delivery system based on core–shell gold nanocages

Ji¹,

Qiu²,

Hou³

et al. 2018

IJN

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BackgroundIn order to achieve drug targeting and controlled release, we have successfully developed a novel drug release system DOX/AuNCs-PM-HA with gold nanocages (AuNCs) as photothermal cores, thermally responsive copolymer P(NIPAM-co-Am) (PM) as the near-infrared (NIR) stimuli gatekeeper and hyaluronic acid as a targeting ligand as well as a capping agent.MethodsCell uptake and cell viability were investigated. In vivo photoacoustic tomography imaging in H22 tumor bearing mice was analyzed for the tumor targeting effect of the nanocomplexes. Antitumor efficacy and the tissue distribution in vivo were investigated.ResultsIn vitro results demonstrated that the DOX/AuNCs-PM-HA had significant anticancer activity against SMMC-7721 cells under NIR irradiation. Furthermore, in vivo photoacoustic tomography imaging of the nanocomplexes in H22 tumor bearing mice could indicate effective tumor targeting. Our studies on antitumor efficacy and the tissue distribution in vivo showed that many DOX/AuNCs-PM-HA nanocomplexes could efficiently accumulate at the tumor site so that they could inhibit the tumor growth effectively with limited side effects. The in vitro and in vivo results confirmed that the tumor-targeting and controlled-release drug system DOX/AuNCs-PM-HA with the combination of chemotherapy and photothermal therapy showed strong anti-tumor effect and would have great potential for future cancer therapy.ConclusionThis tumor targeting DOX/AuNCs-PM-HA nanocomplex responded not only to the external stimuli of NIR, but also the internal stimuli of hyaluronidase, providing the potential for pinpointed and multi-stimuli responsive intracellular drug release.

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“…For example, MHA demonstrated a temperature increase of 40 °C in 1 min, whereas the polycaprolactone (PCL) scaffold loaded with magnetite (Fe3O4) reached a 9 °C increase in 5 min, both using an external MF of 30 mT at 293 kHz [22], moreover using different exposure conditions. All the studies on magnetic scaffolds focus on the synthesis, characterization and proof-of-concept of such therapeutic biomaterials [24][25][26][27][28][29]. However, none of them has ever modeled completely the physical properties of the scaffolds to accurately define hyperthermia treatment, also including and simulating healthy and pathologic tissues.…”

mentioning

confidence: 99%

Numerical Investigation of Bone Tumor Hyperthermia Treatment Using Magnetic Scaffolds

Fanti

Lodi

Vacca

et al. 2018

IEEE J. Electromagn. RF Microw. Med. Biol.

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This works claims to define, via numerical simulations, magnetic field parameters to perform an effective in situ bone tumor hyperthermia treatment using magnetic scaffolds. A Cole-Cole model to describe the frequency response of the magnetic susceptibility of nanoparticles embedded in novel magnetic biomaterials is explored. The heating phenomena is investigated considering both the ischemic and inflamed state of the fracture gap at the bone/implants interface. Both Osteosarcoma and Fibrosarcoma tumors are analyzed. Magnetic hydroxyapatite and poly-ε-caprolactone scaffolds are investigated. From the thermal analysis, it is found that the fracture behaves as a resistance to heat conduction, therefore strength and frequency of external magnetic field has to be tuned to perform the treatment taking the fracture status into account. Moreover, numerical experiments indicate that low perfused Fibrosarcoma can be treated using moderate-strength field, whereas more intense external fields are required to treat strongly vascularized Osteosarcoma without damaging healthy bone tissue. Magnetic hydroxyapatite stands out to be the most performant and versatile material to treat both tumors. These simulations can be regarded as a starting point to analyze possible clinical use of magnetic scaffolds for in situ bone hyperthermia.

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Multifunctional magnetic nanostructured hardystonite scaffold for hyperthermia, drug delivery and tissue engineering applications

Cited by 72 publications

References 37 publications

Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

Construction and application of a liver cancer-targeting drug delivery system based on core–shell gold nanocages

Numerical Investigation of Bone Tumor Hyperthermia Treatment Using Magnetic Scaffolds

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Multifunctional magnetic nanostructured hardystonite scaffold for hyperthermia, drug delivery and tissue engineering applications

Cited by 72 publications

References 37 publications

Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

Construction and application of a liver cancer-targeting drug delivery system based on core&ndash;shell gold nanocages

Numerical Investigation of Bone Tumor Hyperthermia Treatment Using Magnetic Scaffolds

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Construction and application of a liver cancer-targeting drug delivery system based on core–shell gold nanocages