Multifunctional magnetically removable nanogated lids of Fe3O4–capped mesoporous silica nanoparticles for intracellular controlled release and MR imaging

Chen, Po Jung; Hu, Shang Hsiu; Hsiao, Chi Sheng; Chen, You Yin; LIu, Dean-Mo; Chen, San‐Yuan

doi:10.1039/c0jm02590a

Cited by 113 publications

(58 citation statements)

References 34 publications

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“…As illustrated in Figure 15, Chen et al 151 constructed a novel nanocarrier (MSN@Fe 3 O 4 ) using a facile technology by capping amine-modified MSN with 2,3-dimercaptosuccinic acid-functionalized Fe 3 O 4 nanoparticles through chemical amidation. In the absence of magnetic field, a negligible amount of the drug was released from the MSN@Fe 3 O 4 .…”

mentioning

confidence: 99%

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Song

et al. 2016

IJN

202

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mentioning

confidence: 99%

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Song

et al. 2016

IJN

202

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“…Different amounts of three different functionalized MNPs (15,60 and 100 mgs; suitable for in vivo hyperthermia) have been used for their encapsulation into hydrogel particles. Table 1 lists their actual amounts along with the percentage weight obtained from TGA analysis.…”

Section: Magnetic Nanohydrogels (Mnhg) Synthesismentioning

confidence: 99%

A comparative study on thermoresponsive magnetic nanohydrogels: role of surface-engineered magnetic nanoparticles

et al. 2011

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A comparative study of thermoresponsive poly(Nisopropylacrylamide)(PNIPAAm)-chitosan (CS)-based magnetic nanohydrogels (MNHGs) encapsulating functionalized Fe 3 O 4 nanoparticles (NPs) in terms of the parameters governing their suitability for real hyperthermia is reported. Iron oxide NPs functionalized with (a) citric acid (CA-Fe 3 O 4 ), (b) ethylenediamine (Amine-Fe 3 O 4 ) and (c) dimercaptosuccininc (DMSAFe 3 O 4 ) have been synthesized and their encapsulation into MNHGs was obtained through physical encapsulation method. The structural characterizations of synthesized materials include X-ray diffraction, FT-IR, TGA, ICP-AES and X-ray photoelectron spectroscopy (XPS). Encapsulation of the functionalized NPs into MNHGs were observed in TEM micrographs, while SEM and AFM micrographs confirmed their spherical morphology (~250-300 nm). Lower critical solution temperature (LCST) variation was measured by UV-visible spectrophotometer and differential scanning calorimetry (DSC). MNHGs exhibited sufficient magnetization and heating ability for hyperthermia. Typically, hydrogels containing CA-Fe 3 O 4 (50 mg/ml) raised the temperature of the medium to 43°C, a suitable dose for in vivo application in tumor-bearing mice.

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“…The basis for the interest lies in their unique properties achieved at the nanoscale that can be accessed via remote stimuli. These properties could then be exploited to simultaneously activate secondary systems that are not remotely actuatable [440,535,536,[553][554][555][556][557][558][559][560][561]. Despite all the work already performed, Richard Feynman is still more than right: "There is still Plenty of Room at the Bottom".…”

Section: Perspectives: Multimodal Theranostic Npsmentioning

confidence: 99%

“…These MR/optical imaging agents can be used to monitor enzyme activity, in brain tumor imaging, and to detect and monitor apoptosis and atherosclerosis [439]. Other types of multimodal contrast agents [5,25,74,200,201,281,430,432,433,436,437,[440][441][442] such as probes with three modes of imaging are considered, for example MRI/NIRF/PET [439], and even four [425,439,443,444] which are gathered in Table 3. As an example, difficulty in delineating brain tumor margins is a major obstacle for further efficient treatment This provided non-invasive tumor delineation by the three modalities and through the intact skull.…”

Section: Multimodal Nanoprobesmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

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The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in synthesis protocol and characterization of these materials whereas toxicological issues are sometimes incomplete. Nanoparticle-based contrast agents tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of 2 imaging modalities. Multimodal nanoparticles (NPs) are much more efficient than conventional molecular-scale contrast agents. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides specific applications for classical imaging, (MRI, PET, CT, US, PAI) are also mentioned less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA).Perspectives on multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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Multifunctional magnetically removable nanogated lids of Fe3O4–capped mesoporous silica nanoparticles for intracellular controlled release and MR imaging

Cited by 113 publications

References 34 publications

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

A comparative study on thermoresponsive magnetic nanohydrogels: role of surface-engineered magnetic nanoparticles

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

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