Multifunctional mats by antimicrobial nanoparticles decoration for bioinspired smart wound dressing solutions

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

“…Such coatings have been studied out of the desire to improve the bioactivity (by encouraging initial adhesion of host cells onto the implant and by supporting normal cellular growth) and corrosion resistance of metallic implants [21,22]. Moreover, successful results have been reported by using polymeric films for surface modification of materials used in wound healing applications, as they enable the fabrication of specific hydrophilic/hydrophobic devices, with enhanced stability and fluid absorption, controllable permeability and tunable swelling behavior [23,24]. In addition, they have been evaluated as particular biofunctional interfaces, which possess anti-fouling activity, antimicrobial efficiency, local drug release ability, immunomodulatory role and wound healing effects [25][26][27][28].…”

Special Features of Polyester-Based Materials for Medical Applications

“…Healing of wounds requires dressings with hydrophilic surfaces, which contribute to supporting cell adhesion better than hydrophobic surfaces. For example, CuO and ZnO NPs with contact angle values of 85° and 78° [ 20 ] and TiO 2 NPs [ 18 ] were successfully used to increase the surface wettability of polyesters for wound applications.…”

“…Coated melanin–TiO 2 /PCL/PHB mats allowed researchers to obtain a water absorption of 300 wt % [ 18 ], further supporting a key role for keeping the moisture balance in wound-dressing materials. The adding of gelatin to PHB nanofibers enabled them to obtain a wound-dressing material useful in treating second-degree burn wounds by decreasing the dressing frequency and the controlled released of silver sulfadiazine (SS) [ 24 ].…”

“…The addition of acetic acid to the mixture of chloroform:ethanol to dissolve the PLCL/PCL copolymer prevented the formation of beads, and led to fibers with diameters in the range of 200 nm to 2.8 µm [ 163 ]. There were also reported nanofibers with diameters of 1.68 ± 0.58 µm and 1.51 ± 0.64 µm in the case of electrospun PLA/HPO [ 21 ], 1.107–1.243 µm in the case of PLA/GO/Q [ 162 ], and 1.9 ± 0.5 μm in the case of PHB/PCL modified with hybrid melanin–TiO 2 nanostructures [ 18 ], which are considered as adequate for cell adhesion and attachment. However, the nanofibers’ average diameters of 599.94 ± 112.04 nm [ 16 ], or in the range of 250–300 nm [ 20 ], permitted the controlled drug release, antimicrobial activity, and acceleration of the wound-healing process.…”

“…Wound-dressing materials should have important requirements related to their biocompatibility [ 15 ], wound healing [ 16 ], wound adhesion [ 17 , 18 ], maintenance of wound moisture [ 19 , 20 ], inhibition of the growth of bacteria [ 15 , 21 , 22 ], removal of excess exudates, and reductions in the dressing frequency [ 23 , 24 ].…”