2023
DOI: 10.1016/j.matdes.2023.112252
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Multifunctional metal–organic frameworks for wound healing and skin regeneration

Fei Xing,
Hong Ma,
Peiyun Yu
et al.
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Cited by 15 publications
(5 citation statements)
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“…Specifically, GS5-CL-Ag@CD-MOF embodies a synergistic design where the MOF structure not only facilitates targeted delivery but also contributes intrinsically to the healing process. 211 The inclusion of silver (Ag) within the MOF framework provides antimicrobial properties, a critical factor in preventing infection and promoting wound healing. 209 Furthermore, the cyclodextrin component enhances the solubility and stability of encapsulated drugs, ensuring efficient delivery to the wound site.…”
Section: Efficacy Of Cd-mof Transdermal Drug Delivery Systemsmentioning
confidence: 99%
“…Specifically, GS5-CL-Ag@CD-MOF embodies a synergistic design where the MOF structure not only facilitates targeted delivery but also contributes intrinsically to the healing process. 211 The inclusion of silver (Ag) within the MOF framework provides antimicrobial properties, a critical factor in preventing infection and promoting wound healing. 209 Furthermore, the cyclodextrin component enhances the solubility and stability of encapsulated drugs, ensuring efficient delivery to the wound site.…”
Section: Efficacy Of Cd-mof Transdermal Drug Delivery Systemsmentioning
confidence: 99%
“…The biocompatibility and toxicity of MOFs remain uncertain, posing challenges due to the significant release of metal ions and organic ligands, the innate characteristics of the material, and the low degradation rate and cellular accumulation of MOFs and their components, which hinders metabolic processes and excretion. 78 2.4. Antibacterial Peptide-Based Nanoparticles.…”
Section: Polymer Nanoparticles With Antibacterialmentioning
confidence: 99%
“…Unlike many other nanoparticles, MOFs are still in the early stages of research and demand further investigation. The biocompatibility and toxicity of MOFs remain uncertain, posing challenges due to the significant release of metal ions and organic ligands, the innate characteristics of the material, and the low degradation rate and cellular accumulation of MOFs and their components, which hinders metabolic processes and excretion …”
Section: Nanoparticles With Antibacterial Propertiesmentioning
confidence: 99%
“…13 Metal organic frameworks (MOFs) have also drawn a lot of interest due to their potential benefits in treating skin injuries. 14 For example, Chen et al utilized Zn-based MOFs and showed that the porous nature of this materials could rapidly degrade under weakly acidic conditions (pH = 5.5), resulting in the long-term release of zinc ions for wound healing applications. 15 Zhang et al reported the control release of nitric oxide (NO) using Cu-Based MOFs HKUST-1.…”
Section: Introductionmentioning
confidence: 99%