“…It has garnered increasing attention in TE thanks to its excellent antioxidant properties, anti-inflammatory activity, ability to block tumor necrosis factor-alpha (TNF-α), promotion of granulation tissue formation and re-epithelialization, and potential to hinder microorganisms’ growth . Furthermore, the pH-responsive color change of curcumin broadens its application for real-time monitoring of the wound healing process, enabling the development of smart wound management. ,− Notwithstanding, the extremely poor water solubility (with reported values ranging from 11 to 600 ng·ml –1 ), low stability, and insufficient bioavailability of curcumin have limited its performance. , To address these challenges, researchers have proposed modifying the characteristics of curcumin through nanoformulation, emulsification, surface modification/functionalization, conjugation, and complexation. − Incorporating lipophilic curcumin into a suitable hydrophilic polymer is expected to enhance its bioactivity and release in practice, , particularly in the wound area. Nonetheless, controlling the release of this drug remains a subject of extensive research. ,, …”