Multifunctional Microspheres Based on D-Mannose and Resveratrol for Ciprofloxacin Release

Cassano, Roberta; Curcio, Federica; Procopio, Debora; Fiorillo, Marco; Trombino, Sonia

doi:10.3390/ma15207293

Cited by 4 publications

(3 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stearic acid, THF and hydroquinone monostearate were placed in a three-necked flask equipped with a reflux condenser, carefully flamed and kept under nitrogen. Immediately after dissolution of the hydroquinone, DCC and DMAP were added in sequence and stirred for 24 h. The reaction was filtered using a porosity 4 filter and then taken to the rotavapor for the removal of the remaining solvent and the by-product dicyclohexylurea [ 22 , 23 ]. The reaction was conducted in accordance with the procedure reported in the literature.…”

Section: Methodsmentioning

confidence: 99%

Solid Lipid Nanoparticles Hydroquinone-Based for the Treatment of Melanoma: Efficacy and Safety Studies

Trombino

Malivindi

Barbarossa³

et al. 2023

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

Classical melanoma therapy has several side effects that are responsible for a decrease in the final therapeutic efficacy. It is possible that the drug is degraded before reaching the target site and is metabolized by the body itself, resulting in repeated doses being administered throughout the day and a decrease in patient compliance. Drug delivery systems avoid degradation of the active ingredient, improve release kinetics, prevent the drug from being metabolized before reaching the site of action, and improve the safety and efficacy profiles of adjuvant cancer therapy. The solid lipid nanoparticles (SLNs) based on hydroquinone esterified with stearic acid realized in this work represent a chemotherapeutic drug delivery system that is useful in the treatment of melanoma. The starting materials were characterized by FT-IR and 1H-NMR, while the SLNs were characterized by dynamic light scattering. In efficacy studies, their ability to influence anchorage-dependent cell proliferation was tested on COLO-38 human melanoma cells. Furthermore, the expression levels of proteins belonging to apoptotic mechanisms were determined by analyzing the role of SLNs in modulating the expression of p53 and p21WAF1/Cip1. Safety tests were conducted to determine not only the pro-sensitizing potential but also the cytotoxicity of SLNs, and studies were conducted to assess the antioxidant and anti-inflammatory activity of these drug delivery.

show abstract

Section: Methodsmentioning

confidence: 99%

Solid Lipid Nanoparticles Hydroquinone-Based for the Treatment of Melanoma: Efficacy and Safety Studies

Trombino

Malivindi

Barbarossa³

et al. 2023

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

show abstract

“…The course of the reaction was followed by thin-layer chromatography of a chloroform/hexane eluent mixture (5:5). The resulting product (ester) was purified by filtration and washing in hot methanol to remove the residual dicyclohexylurea (DCU), i.e., the condensation reaction by-product of DCC with amines and alcohols, formed and the remaining solvent residue [52,53].…”

Section: Synthesis Of Thementioning

confidence: 99%

ROS-Responsive PLGA-NPs for Co-Delivery of DTX and DHA for Colon Cancer Treatment

Cassano,

Trombino,

Curcio

et al. 2024

IJTM

Self Cite

View full text Add to dashboard Cite

The aim of this work was to evaluate the antineoplastic effect of newly synthesized nanoparticles based on poly(lactic-co-glycolic acid) (PLGA) alone or PLGA esterified with 2,2′-[propane-2,2-diylbis (thio)] diacetic acid (TKL), loaded with docetaxel (DTX) and/or docosahexaenoic acid (DHA), as innovative site-specific therapeutic carriers. The obtained materials were characterized by FT-IR and 1H-NMR, while the dimensional analysis of the nanoparticles obtained was performed by Dynamic Light Scattering. The encapsulation efficiency of the nanoparticles was evaluated, and in vitro skin permeation tests were also performed. The antitumor activity of the nanomaterial was studied in the human adenocarcinoma HCT116 cell line. In particular, viability tests in bidimensional culture, as well as in tumor spheroids, were conducted. The use of these nanocarriers could facilitate the stable and efficient delivery of DTX and DHA through the upper segments of the gastrointestinal tract to the colon. In addition, the presence of the ROS-sensitive 2,2′-[propane-2,2-diylbis (thio)] diacetic acid in their matrix should promote the site-specific release of DTX in the tumor mass, where high levels of reactive oxygen species could be found.

show abstract

“…To facilitate the topical administration of phloretin, it is possible to use formulations able to improve the dissolution of the drugs, increasing their stability and bioavailability [ 22 , 23 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Transdermal Delivery of Phloretin by Gallic Acid Microparticles

Cassano

Curcio

Sole

et al. 2023

Gels

Self Cite

View full text Add to dashboard Cite

Exposure to ultraviolet (UV) radiation causes harmful effects on the skin, such as inflammatory states and photoaging, which depend strictly on the form, amount, and intensity of UV radiation and the type of individual exposed. Fortunately, the skin is endowed with a number of endogenous antioxidants and enzymes crucial in its response to UV radiation damage. However, the aging process and environmental stress can deprive the epidermis of its endogenous antioxidants. Therefore, natural exogenous antioxidants may be able to reduce the severity of UV-induced skin damage and aging. Several plant foods constitute a natural source of various antioxidants. These include gallic acid and phloretin, used in this work. Specifically, polymeric microspheres, useful for the delivery of phloretin, were made from gallic acid, a molecule that has a singular chemical structure with two different functional groups, carboxylic and hydroxyl, capable of providing polymerizable derivatives after esterification. Phloretin is a dihydrochalcone that possesses many biological and pharmacological properties, such as potent antioxidant activity in free radical removal, inhibition of lipid peroxidation, and antiproliferative effects. The obtained particles were characterized by Fourier transform infrared spectroscopy. Antioxidant activity, swelling behavior, phloretin loading efficiency, and transdermal release were also evaluated. The results obtained indicate that the micrometer-sized particles effectively swell, and release the phloretin encapsulated in them within 24 h, and possess antioxidant efficacy comparable to that of free phloretin solution. Therefore, such microspheres could be a viable strategy for the transdermal release of phloretin and subsequent protection from UV-induced skin damage.

show abstract

Multifunctional Microspheres Based on D-Mannose and Resveratrol for Ciprofloxacin Release

Cited by 4 publications

References 38 publications

Solid Lipid Nanoparticles Hydroquinone-Based for the Treatment of Melanoma: Efficacy and Safety Studies

Solid Lipid Nanoparticles Hydroquinone-Based for the Treatment of Melanoma: Efficacy and Safety Studies

ROS-Responsive PLGA-NPs for Co-Delivery of DTX and DHA for Colon Cancer Treatment

Transdermal Delivery of Phloretin by Gallic Acid Microparticles

Contact Info

Product

Resources

About