Multifunctional modification of Fe3O4 nanoparticles for diagnosis and treatment of diseases: A review

Miao, Qiguang; Xu, Mengjie; Niu, Ling; Cheng, Yizhu; Niu, Xiaolian; Kong, Jinlong; Zhang, Xiumei; Yan, Wei; Huang, Di

doi:10.1007/s11706-021-0543-y

Cited by 8 publications

(1 citation statement)

References 122 publications

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“…Currently, Fe 3 O 4 nanoparticles have received increasing attention due to their simple syntheses and stable storage in the colloidal form 7,11 . Nevertheless, the agglomeration of nanoparticles is expected over time to reduce the surface energy provided by the large surface area of nanoparticles 1,[12][13][14] . Moreover, the oxidation process reduces magnetic properties.…”

Section: Introductionmentioning

confidence: 99%

The Effect of EDTA Functionalization on Fe3O4 Thermal Behavior

et al. 2022

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The surface of Fe 3 O 4 nanoparticles is very reactive and can oxidize to γ-Fe 2 O 3 (maghemite) and α-Fe 2 O 3 (hematite) structures. Based on this, the oxidation process of Fe 3 O 4 nanoparticles must be prevented, and one of the strategies is surface functionalization with organic or inorganic molecules. Thus, this study analyzed the thermal behavior of Fe 3 O 4 and Fe 3 O 4 -EDTA nanoparticles using X-ray diffraction (XRD), simultaneous thermogravimetry-differential thermal analysis (TG-DTA), differential scanning calorimetry (DSC). Results showed that γ-Fe 2 O 3 was obtained as an intermediate in Fe 3 O 4 and Fe 3 O 4 -EDTA decomposition, as confirmed by TG-DTA and DSC curves. Moreover, Fe 3 O 4 -EDTA exhibited a temperature peak (T p = 573.5°C) of phase transformation (γ-Fe 2 O 3 → α-Fe 2 O 3 ) higher than that of Fe 3 O 4 (T p = 533.0°C), confirming that EDTA molecules stabilized the nanoparticles efficiently. The kinetic behavior of samples changed, and the activation energy for functionalized samples decreased.

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