Multifunctional nanodiamonds as emerging platforms for cancer treatment, and targeted delivery of genetic factors and protein medications—a review

Mumtaz, Mehvish; Hussain, N.; Salam, Sidra; Bilal, Muhammad

doi:10.1007/s10853-022-07168-x

Cited by 17 publications

(4 citation statements)

References 227 publications

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“…In study [16], intends to further future studies on biomineralization-based cancer treatment. The impediment to clinically effective nanomaterial transformation may be solved by the rational design of nanoparticle medication delivery systems.…”

Section: Literature Reviewmentioning

confidence: 99%

Analysis of Silver Nanoparticles as Carriers of Drug Delivery System

Pawar,

Korde,

Rakshe

et al. 2023

J. Nano- Electron. Phys.

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Nanotechnology has advanced significantly over the last decade and has found several uses in fields as diverse as medical, pharmaceuticals, microelectronics, aerospace, and the food industry. The use of nanoparticle (NP) drug carriers has been investigated, and this method offers several benefits. Some of these benefits include the controlled and targeted release of loaded or coupled drugs, as well as an improvement in the bioavailability of the drug. However, they also have certain drawbacks, such as their in vivo toxicity, which affects all organs, including the healthy ones, and the overall benefit of the illness therapy, which might be insignificant or limited. Due to their unique physical, chemical, and optical characteristics, AgNP have attracted a lot of attention in recent years. These NP have several potential uses, including drug delivery. Methods that get around these problems are crucial since traditional cancer chemotherapy has several drawbacks, including limited bioavailability and the need for high dosages that have side effects. The study examines AgNP as a drug delivery system for the treatment of cancer. The paper also examines the most recent developments in the use of AgNP for the delivery of anticancer medications and their impact on antitumor effects. It is also observed that silver nano particles can characterize their physicochemical properties and determine the presence of any potential toxicity.

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Section: Literature Reviewmentioning

confidence: 99%

Analysis of Silver Nanoparticles as Carriers of Drug Delivery System

Pawar,

Korde,

Rakshe

et al. 2023

J. Nano- Electron. Phys.

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“…With robotic surgery aided and guided by quantum computer programs, for more complex surgeries, it "could be a total game changer" totally avoiding fatigue and increasing procedure safety and success rates [32] We already have automation in other areas of human treatment. For example, the recent article titled "Globus Medical Announces Frist Surgeries Using Excelsius3D.…”

Section: Enhanced Robotic Surgery With Quantum Computingmentioning

confidence: 99%

At The Intersection of Medical Robotic Surgery and Drug Discovery with Quantum Computing

2023

JEEE

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Classical natural language processing (NLP) has been successfully modeled and implemented to enable robots or chatbots to have some understanding of human languages and communication, but this has not been very effective to help the robots communicate effectively. Quantum computers introduce a multitude of new ways in which more highly complex and integrated robotics modeling and computations can be achieved, delivering finer control in robotics use cases with humans. As mentioned in articles “Genome assembly using quantum and quantum‑inspired annealing” “The pandemic highlighted the importance of and breadth of robotics applications, shining a light on a potential robotic future in healthcare, which we discuss here”, there is a lot more to explore in quantum computing. However, in this study, we will present how quantum robotics can help in developing superior surgical techniques where robots perform advanced medical surgeries, with a more sophisticated, faster, less intrusive process that achieves more successful patient outcomes in complex surgery processes that might otherwise take repeat surgeries with multiple human medical teams. This approach will include the use of quantum natural language processing (QNLP) [1,2]

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“…typically possesses a high ionic strength reducing the thickness of the stabilizing electrical double layer around the NPs, dispersing such particles leads to their poor colloidal stability, aggregation and limited biological availability. [50,51] Potentially, serum proteins can be used to stabilize such particles. [51] To improve the colloidal stability of the previous generation of coatings, polymers of higher molecular weight are required.…”

Section: Introductionmentioning

confidence: 99%

Design Rules for the Nano‐Bio Interface of Nanodiamonds: Implications for siRNA Vectorization

Kindermann,

Neburkova,

Neuhoferova

et al. 2024

Adv Funct Materials

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The enormous therapeutic potential of selective ribonucleic acid (RNA) interference has recently been manifested by the approval of several small interfering RNA (siRNA)‐based drugs. However, the efficacy of siRNA delivery is still limited, and an extensive search for alternative and highly effective delivery approaches is ongoing. With this aim, three generations of non‐viral vectors based on modified nanodiamonds (NDs) have been gradually developed in the past decade. They show great promise due to the negligible toxicity of the ND core. Here, a robust methodological approach is presented to enable the evaluation of new vector nanomaterials. Using a new type of third‐generation ND vector coated with a copolymer with tunable charge density, variables such as colloidal stability, surface electrostatic properties, the molecular composition of the copolymer, and the mode of complexation with siRNA are optimized. Using an innovative data processing strategy, the results are related to biological potency, toxicity, and cell proliferation. Finally, the optimized composition of a coating copolymer consisting of a cationic component, 2‐dimethylaminoethyl methacrylate, and an electroneutral biocompatible component, N‐(2‐hydroxypropyl) methacrylamide, is evaluated. The optimized NDs vectors are colloidally and biologically stable siRNA delivery tools with broad potential for RNA interference‐based therapeutics.

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Multifunctional nanodiamonds as emerging platforms for cancer treatment, and targeted delivery of genetic factors and protein medications—a review

Cited by 17 publications

References 227 publications

Analysis of Silver Nanoparticles as Carriers of Drug Delivery System

Analysis of Silver Nanoparticles as Carriers of Drug Delivery System

At The Intersection of Medical Robotic Surgery and Drug Discovery with Quantum Computing

Design Rules for the Nano‐Bio Interface of Nanodiamonds: Implications for siRNA Vectorization

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