Multifunctional nanoparticles for prostate cancer therapy

Salvador-Morales, Carolina; Gao, Weiwei; Ghatalia, Pooja; Murshed, Farhan; Aizu, Wataru; Langer, Robert; Farokhzad, Omid C.

doi:10.1586/14737140.9.2.211

Cited by 27 publications

(18 citation statements)

References 77 publications

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“…To our knowledge, dextran-camptothecin (DE-310) has the longest circulation half-life (~300 h) in humans and has been shown to have no major toxicity compared to the free drug formulation in clinical phase II trials. [1,3,5,12,[13][14][15][16][17][18] In general, larger nanoparticles such as micelles and liposomes seem to have a shorter circulation half-life in the blood (2-50 h) but higher maximum tolerated doses. The Genexol-PM formulation of paclitaxel is given at a twofold higher dosage than HPMA-paclitaxel (PNU166945) and polyglutamate-paclitaxel (Xyotax).…”

Section: Nanoparticles In Clinical Trialmentioning

confidence: 99%

Nano cancer therapy strategies

Tiwari

2012

J Can Res Ther

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Cancer is a leading cause of deaths. Millions of people are diagnosed with cancer every year. Many cancer cells have a protein all over their surface, while healthy cells typically do not express the protein as strongly. By conjugating, or binding, the gold nanoparticles to an antibody the researchers were able to get the nanoparticles to attach themselves to the cancer cells which may help us unravel the inner workings of a cancer cell and produce better treatments. In terms of drug delivery systems, nano particles enable unique approaches for cancer treatment. A large number of nanoparticle delivery systems have been developed for cancer therapy and currently they are in the preclinical stages of development. More recently developed nanoparticles are demonstrating the potential sophistication of these delivery systems by incorporating multifunctional capabilities and targeting strategies in an effort to increase the efficacy of these systems against the most difficult cancer challenges. This article reviews the available preclinical and clinical nanoparticle technology platforms and their impact on cancer therapy.

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Section: Nanoparticles In Clinical Trialmentioning

confidence: 99%

Nano cancer therapy strategies

Tiwari

2012

J Can Res Ther

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“…Brachytherapy, Cyberknife ® (Accuray, CA, USA) and radiofrequency ablation have not been evaluated in a focal therapy protocol, but could be delivered in a focal manner. Magnetic resonance hyperthermia using magnetic nanoparticles as well as electroporation are new modalities that may also hold promise, although both are at Phase I of development [53,54].…”

Section: Ablative Technologymentioning

confidence: 99%

Is Focal Therapy the Future for Prostate Cancer?

Ahmed

Emberton

2010

Future Oncol.

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Focal therapy aims to find a middle ground between surveillance and radical therapies by treating the cancer alone, with a margin, and preserving as much tissue as is practical. Early feasibility studies have demonstrated an absence of rectal toxicity and preservation of genitourinary function in 80-90% of men. The incidence of low- to intermediate-risk prostate cancer is rising owing to informal and formal prostate-specific antigen screening practices. The treatment burden from radical therapies is high with over 50% of men suffering genitourinary or rectal toxicity. Active surveillance, on the other hand, carries surveillance and psychological burden with risk of progression. A research strategy to evaluate focal therapy should be embedded within pragmatic designs using a broad patient group, using the available ablative technologies (cryotherapy, high-intensity focused ultrasound, brachytherapy and photodynamic therapy) with end points derived from biochemical, biopsy and imaging. Within this framework there exists a unique opportunity to undertake landmark diagnostic studies incorporating imaging techniques and biomarkers in addition to studies directed at the biology of prostate cancer over time.

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“…A new terminology was proposed as "paramagnetic nanoparticle targeted hyperthermia and thermometry". These nanoparticles enhance the diagnosis and localization of specific tissue characteristics by multimodal imaging techniques including optical, magnetic resonance, positron emission tomography, computed tomography and X-ray techniques [29][30][31][32][33][34][35][36][37][38]. However, tumor heating by placing multifunctional nanoparticles at tumor sites (hyperthermia) is emerging as an art of tumor treatment by "multimodal nanothermal therapy" [39][40][41].…”

Section: Introductionmentioning

confidence: 99%

State of Art on Bioimaging by Nanoparticles in Hyperthermia and Thermometry: Visualization of Tissue Protein Targeting

Sharma¹,

Sharma²,

Chen³

2011

TONMJ

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Abstract:Heating tumors by nanoparticles and resistance in tumor cells to a high temperature is emerging as an effective tool as nanomedicine tool in cancer therapy. The art of thermal mapping in a tumor at various locations is emerging as the selective approach of hyperthermia to monitor temperature and treat the tumor. However, thermometry and tumor cell interaction with nanoparticles may monitor and evaluate the tumor cell survival after exposure to high physiological temperatures but show cytotoxicity. The design and application of 10-100 nano meter sized nanoparticles in tumor hyperthermia has emerged as an effective technology in hyperthermia imaging and treatment. The temperature and nanoparticle magnetic moment relationship is specific. Furthermore, there are two main issues that are unsolved as of yet. First issue is the relationship of tumor energy changes due to tumor magnetization by different nanoparticles. The second issue is the heat transfer behavior of the nanoparticle inside the tumor combined with hyperthermia and efficacy of combined modality on the tumor tissue temperature rise. In present study, we highlight that in vivo imaging such as MR thermometry, photoacuastic mapping of different tumor locations solve these issues to some extent. The art of combined use of hyperthermia by nanoparticles with hypoxia sensitive nitroimidazole radiosensitizers with chemotherapeutic drugs is highlighted to have a great impact on public health as alternative therapeutic oncology and monitoring therapy.

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Multifunctional nanoparticles for prostate cancer therapy

Cited by 27 publications

References 77 publications

Nano cancer therapy strategies

Nano cancer therapy strategies

Is Focal Therapy the Future for Prostate Cancer?

State of Art on Bioimaging by Nanoparticles in Hyperthermia and Thermometry: Visualization of Tissue Protein Targeting

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