Multifunctional nanoparticles for trimodal photodynamic therapy-mediated photothermal and chemotherapeutic effects

Vivek, Raju; NipunBabu, Varukattu; Rejeeth, Chandrababu; Sharma, Alok; Ponraj, Thondhi; Vasanthakumar, Alagarsamy; Kannan, Soundarapandian

doi:10.1016/j.pdpdt.2018.06.025

Cited by 21 publications

(10 citation statements)

References 32 publications

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“…With respect to in vivo experiments, the NPs obliterated tumour growth with NIR irradiation without remarkable damage to surrounding organs. Histopathological assessment of organ toxicity on kidney, liver and spleen demonstrated no toxicity due to NPs treatment which confirmed the safety and effectiveness of the nanosyystem for breast cancer trimodal PDT/PTT/ chemotherapy [80].…”

Section: Polymeric Nanoparticles/micellessupporting

confidence: 56%

“…Furthermore, an effective trimodal PDT/PTT/ Chemotherapy system was accomplished by folateconjugated polymer NPs [80]. Biodegradable poly (lactic-co-glycolic acid) (PLGA) was linked to ICG as a PS and photothermal agent, and carboplatin (CBP) [cisdiammine-(1,1-cyclobutanedicarboxylato)-platinum(II)], which interfered with DNA damage.…”

Section: Polymeric Nanoparticles/micellesmentioning

confidence: 99%

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Review: Organic nanoparticle based active targeting for photodynamic therapy treatment of breast cancer cells

2020

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Targeted Photodynamic therapy (TPDT) is a non-invasive and site-specific treatment modality, which has been utilized to eradicate cancer tumour cells with photoactivated chemicals or photosensitizers (PSs), in the presence of laser light irradiation and molecular tissue oxygen. Breast cancer is the commonest cancer among women worldwide and is currently treated using conventional methods such as chemotherapy, radiotherapy and surgery. Despite the recent advancements made in PDT, poor water solubility and non-specificity of PSs, often affect the overall effectivity of this unconventional cancer treatment. With respect to conventional PS obstacles, great strides have been made towards the application of targeted nanoparticles in PDT to resolve these limitations. Therefore, this review provides an overview of scientific peer reviewed published studies in relation to functionalized organic nanoparticles (NPs) for effective TPDT treatment of breast cancer over the last 10 years (2009 to 2019). The main aim of this review is to highlight the importance of organic NP active based PDT targeted drug delivery systems, to improve the overall biodistribution of PSs in breast cancer tumour's.

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Section: Polymeric Nanoparticles/micellessupporting

confidence: 56%

Section: Polymeric Nanoparticles/micellesmentioning

confidence: 99%

Review: Organic nanoparticle based active targeting for photodynamic therapy treatment of breast cancer cells

2020

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“…Various excitation strategies such as x-ray radiation, near-infrared light, internal self-luminescence (chemiluminescent and bioluminescent), and radioluminescent nanoparticles and quantum dots have been investigated for PDT of deep-seated targets (104)(105)(106)(107)(108)(109). Continuing research has also been aimed toward targeted delivery of photosensitizers and drugs with nanotechnology (110)(111)(112)(113), although still at the proof-of-principle stage. This depends on the successful synthesis of nanoparticles with high tumor uptake selectivity.…”

Section: Other Technologiesmentioning

confidence: 99%

Light Sources and Dosimetry Techniques for Photodynamic Therapy

Kim

Darafsheh

2020

Photochem & Photobiology

300

225

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Effective treatment delivery in photodynamic therapy (PDT) requires coordination of the light source, the photosensitizer, and the delivery device appropriate to the target tissue. Lasers, light‐emitting diodes (LEDs), and lamps are the main types of light sources utilized for PDT applications. The choice of light source depends on the target location, photosensitizer used, and light dose to be delivered. Geometry of minimally accessible areas also plays a role in deciding light applicator type. Typically, optical fiber‐based devices are used to deliver the treatment light close to the target. The optical properties of tissue also affect the distribution of the treatment light. Treatment light undergoes scattering and absorption in tissue. Most tissue will scatter light, but highly pigmented areas will absorb light, especially at short wavelengths. This review will summarize the basic physics of light sources, and describe methods for determining the dose delivered to the patient.

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“…Wang et al loaded Pt(IV) anticancer drug and Chlorin e6 into layered double hydroxide nanoparticles and found that the nanobybrid showed synergistic cell killing and could overcome cisplatin-resistance 82 . Attempts have also been made to add targeting moieties such as folic acid to the nanoparticles to actively delivery drugs to cancer cells 83 - 85 . Although approaches have been made in nanoparticle-based drug delivery, the diversity and complexity of nanoparticles complicate the drug regulation pathway.…”

Section: Discussionmentioning

confidence: 99%

A low molecular weight multifunctional theranostic molecule for the treatment of prostate cancer

Wang¹,

Sun²,

Wang³

et al. 2022

Theranostics

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Rationale: Although surgery and radiation therapy in patients with low risk prostate cancer appear appropriate and effective, those with high-risk localized disease almost always become hormone refractory and then rapidly progress. A new treatment strategy is urgently needed for patients with high-risk localized prostate cancer, particularly an approach that combines two drugs with different mechanisms. Combinations of photodynamic therapy (PDT) and chemotherapy have shown synergistic effects in clinical trials, but are limited by off-target toxicity. Prostate specific membrane antigen (PSMA) is a well-established biomarker for prostate cancer. Here we describe the use of a PSMA ligand to selectively and simultaneously deliver a potent microtubule inhibiting agent, monomethyl auristatin E (MMAE), and a PDT agent, IR700, to prostate cancers. Methods: Using a bifunctional PSMA ligand PSMA-1-Cys-C6-Lys, we created a novel theranostic molecule PSMA-1-MMAE-IR700. The molecule was tested in vitro and in vivo for selectivity and antitumor activity studies. Results: PSMA-1-MMAE-IR700 showed selective and specific uptake in PSMA-positive PC3pip cells, but not in PSMA-negative PC3flu cells both in vitro and in vivo . In in vitro cytotoxicity studies, when exposed to 690 nm light, PSMA-1-MMAE-IR700 demonstrated a synergistic effect leading to greater cytotoxicity for PC3pip cells when compared to PSMA-1-IR700 with light irradiation or PSMA-1-MMAE-IR700 without light irradiation. In vivo antitumor activity studies further showed that PSMA-1-MMAE-IR700 with light irradiation significantly inhibited PC3pip tumor growth and prolonged survival time as compared to mice receiving an equimolar amount of PSMA-1-IR700 with light irradiation or PSMA-1-IR700-MMAE without light irradiation. Conclusion: We have synthesized a new multifunctional theranostic molecule that combines imaging, chemotherapy, and PDT for therapy against PSMA-expressing cancer tissues. This work may provide a new treatment option for advanced prostate cancer.

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Multifunctional nanoparticles for trimodal photodynamic therapy-mediated photothermal and chemotherapeutic effects

Cited by 21 publications

References 32 publications

Review: Organic nanoparticle based active targeting for photodynamic therapy treatment of breast cancer cells

Review: Organic nanoparticle based active targeting for photodynamic therapy treatment of breast cancer cells

Light Sources and Dosimetry Techniques for Photodynamic Therapy

A low molecular weight multifunctional theranostic molecule for the treatment of prostate cancer

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