Multifunctional nanoplatform based on star-shaped copolymer for liver cancer targeting therapy

Gong, Xuejun; Zheng, Yi; He, Guangzhi; Chen, Kebing; Zeng, Xiaowei; Chen, Zhihong

doi:10.1080/10717544.2019.1625467

Cited by 18 publications

(15 citation statements)

References 48 publications

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“…Finding more appropriate drugs or delivery methods with lower cytotoxicity and fewer side effects are important tasks for HCC chemotherapy. 14,15 Alkaloids are organic compounds containing nitrogen that occur nature, most of which are basic, some of which are neutral (eg, colchicine) or even acidic (eg, theophylline, theobromine). A wide range of pharmacological properties and effects have been reported, such as antimalarial (eg, quinine), antiasthma (eg, ephedrine), anticancer (eg, homoharringtonine), cholinomimetic (eg, galantamine), vasodilatory (eg, vincristine), antiarrhythmic (eg, quinidine), analgesic (eg, morphine), antibacterial (eg, chelerythrine), and antihyperglycemic activities (eg, vincristine and vinblastine).…”

Section: Discussionmentioning

confidence: 99%

<p>IGFBP-3 Is the Key Target of Sanguinarine in Promoting Apoptosis in Hepatocellular Carcinoma</p>

Wang¹,

Wang²,

Li³

et al. 2020

CMAR

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Introduction: Chemotherapeutic treatment of hepatocellular carcinoma (HCC) has always been plagued by nonspecific and side effects. Plant extracts have potential anticancer capabilities with low cytotoxicity and few side effects, but their detailed mechanisms are still unclear, thus limiting their clinical applications. Methods: In this study, five plant extracts were chosen, their inhibition on HCC cell viability was compared by CCK-8 assay and sanguinarine (SAN) was selected. Then, wound healing assay, transwell assay, and apoptosis assay were carried out in Hep3B cells. Bioinformatics methods were performed and IGFBP-3 was predicted the targets of SAN in HCC. The mechanism of SAN regulating IGFBP-3 was explored using qRT-PCR, Western blotting, cell viability assay and apoptosis assay. Meanwhile, knockdown of IGFBP-3 were used by small interfering RNA (siRNA). Results: In five plant extracts, SAN inhibited the proliferation of HCC cell lines most considerably. In addition, apoptosis was promoted, and invasion and migration were inhibited in the Hep3B cell line by treatment with SAN at 2 μM. Bioinformatics indicated that SAN could affect HCC apoptosis through the TP53/IGFBP-3 pathway, and further verification experiments showed that SAN upregulated the expression of insulin-like growth factor binding protein-3 (IGFBP-3) in the Hep3B cell line; SAN also inhibited the expression of Bcl-2 and promoted the expression of BAX and caspase-3. After using siRNA to inhibit the expression of IGFBP-3, the effect of SAN was blocked. Conclusion: Our study further reveals a novel mechanism that IGFBP-3 is an important target of SAN, by upregulating expression of IGFBP-3, SAN promotes apoptosis in HCC. Plain Language SummaryChemotherapy for hepatocellular carcinoma has many side effects, while plant extracts have better advantages; thus, further clarification of the mechanism of plant extracts in HCC is urgently needed. Previous studies have suggested that sanguinarine elicits potential antitumor effects by promoting the apoptosis of cancer cells, but the specific mechanism is still unclear. This study found that sanguinarine can effectively promote the apoptosis of hepatocellular carcinoma cells, and IGFBP-3 is the key target for this effect. Further study on SAN could provide a new model for treating HCC.

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Section: Discussionmentioning

confidence: 99%

<p>IGFBP-3 Is the Key Target of Sanguinarine in Promoting Apoptosis in Hepatocellular Carcinoma</p>

Wang¹,

Wang²,

Li³

et al. 2020

CMAR

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“…There are many reports on the encapsulation drugs and/or its models in micelles, 3,23,32,33,40,42,44,62 microspheres, 25,63,64 and nanoparticles 5,43,65,66 formed by star-shaped PLA-PEG molecules. Star-shaped polymers have a smaller hydrodynamic radius and lower solution F I G U R E 7 Structures of H-shaped (5), dumbbell-shaped ( 6) polymers.…”

Section: Drug Deliverymentioning

confidence: 99%

“…Scheme 2). 62 Star-shaped PEG-PLA self-assembled into nanoparticles with a size of 50 nm and critical micellar concentration of 2.10 μg mL −1 and hydrophobic drug (doxorubicin) was efficiently encapsulated into the core of particles. An in vitro study demonstrated that the nanocarrier can ferry doxorubicin selectively into tumor tissue, rapidly enter cancer cells, and release its payload in response to an intracellular reductive environment, resulting in excellent antitumor activity in vitro.…”

Section: In Vitro and In Vivo Investigationsmentioning

confidence: 99%

Star‐shaped copolymers with PLA–PEG arms and their potential applications as biomedical materials

Kubisa

Łapienis

Biela

2021

Polymers for Advanced Techs

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This review is devoted to the star-shaped polylactide-b-poly(ethylene glycol) (PLA-b-PEG) polymers with hydrophobic-hydrophilic arms. Star-shaped polymers have a more compact structure as compared to linear counterparts but what is more important contain more end-groups. If end-groups are hydrophilic (such as hydroxyl groups), it may shift the hydrophilic-hydrophobic balance of hydrophobic polymer such as PLA. Additional improvement of hydrophilicity may be achieved by introducing poly(ethylene glycol) segments. In this review, we are discussing synthetic approaches and basic properties of star-shaped polylactide-b-poly(ethylene glycol) (PLA-b-PEG). The introduction of hydrophilic fragments (PEG) into hydrophobic chains (PLA) causes the considerable change of many properties of PLA polymers and extends their applications, particularly biomedical. The influence of the architecture and the number of arms of synthesized polymers as well as the content of hydrophilic and hydrophobic blocks on their properties is also discussed. Particular emphasis is placed on researches on the obtained polymers (in vitro and in vivo) as potential materials for biomedical applications.

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“…In another report, Gong and colleagues have synthesized CA derived star-shaped poly (lacticco-glycolic acid) (PLGA)-polyethylene glycol (PEG)-lactobionic acid (LA) polymer and fine-tuned the liver targeting potency of their as-synthesized polymeric nanoparticle. [67] Jeong et al have reported the synthesis of lactic acid conjugated polycholate nanoparticle and shown their assembling ability toward Erythropoietin encapsulation. [68] Feng et al reported the CA conjugated tri-armed PEG-based star-like block copolymer via ATRP method.…”

Section: Design Trends Of Cholic Acid-based Polymersmentioning

confidence: 99%

Recent Progress in Macromolecular Design and Synthesis of Bile Acid‐Based Polymeric Architectures

Sahoo

Ghosh

Khan

et al. 2021

Macro Chemistry & Physics

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Macromolecular engineering presents a pleasant tactic for planning the construction of desired molecular architectures from nano to macro configurations. The mechanistic pathways and synthetic features of macromolecular designs mostly rely on the precursor composition, topology, functionality, and complexity in architectures. Specifically, macromolecular design with biomolecular conjugation has attracted remarkable attention due to its typical biochemical and physiological affirmative traits. In this review article, it is intended to highlight the major progress on the macromolecular designs and synthesis of polymers comprising bile acid (BA) as the biomolecular colleague. BAs are steroidal biocomposites, produced through cholesterol metabolism in the bile of mammals and vertebrates. They are low priced, biocompatible, abundant, trivially toxic, and structurally unique for facewise amphiphilicity, which make them suitable for designing BA-based polymers (BAPs) to be utilized in biomedical fields. The major aim of this review article is to summarize the recent progress (2015-present) on the requisite necessity of BA in BAPs toward design and synthetic avenues. In particular, the design of various polymers with primary and secondary BAs at side chain, main chain, chain end, crosslinking zone, and core confined area are illustrated in this review article via numerous reported methods.

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Multifunctional nanoplatform based on star-shaped copolymer for liver cancer targeting therapy

Cited by 18 publications

References 48 publications

<p>IGFBP-3 Is the Key Target of Sanguinarine in Promoting Apoptosis in Hepatocellular Carcinoma</p>

<p>IGFBP-3 Is the Key Target of Sanguinarine in Promoting Apoptosis in Hepatocellular Carcinoma</p>

Star‐shaped copolymers with PLA–PEG arms and their potential applications as biomedical materials

Recent Progress in Macromolecular Design and Synthesis of Bile Acid‐Based Polymeric Architectures

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