Multifunctional Nanoplatform for Targeted Laser-induced Hyperthermia and Microscopy of Breast Cancer Cells using SPION-based Gold and Folic Acid Conjugated Nanodendrimers: An in vitro Assay

Khosroshahi, Mohammad E.; Tajabadi, Maryam

doi:10.4172/2157-7439.1000432

Cited by 1 publication

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References 59 publications

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“…One of the most promising magnetic materials for biomedical use is superparamagnetic iron oxide nanoparticles (SPIONs). Literature shows that modification of the SPIONs, as well as the surface modification with various agents to step closer against the most common type of cancer in women-breast cancer [18][19][20]. The application of SPION allows for simultaneous treatment and monitoring of the tumor growth using and magnetic resonance imaging [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin

et al. 2021

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Cancer is one of the most common causes of death worldwide, thus new solutions in anticancer therapies are highly sought after. In this work, superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with anticancer drugs are synthesized and investigated as potential magnetic drug nanocarriers for local drug delivery and mild magnetic hyperthermia. We have obtained a hybrid system loaded with holmium and anticancer drugs and thoroughly studied it with respect to the size, morphology, surface modifications and magnetic properties, and interactions with the model of biological membranes, cytotoxicity. We present that nanoparticles having a round shape and size 15 nm are successfully stabilized to avoid their agglomeration and modified with doxorubicin or epirubicin within a controlled way. The number of drugs loaded into the SPIONs was confirmed with thermogravimetry. The hybrid based on SPIONs was investigated in touch with model biological membranes within the Langmuir-Blodgett technique, and results show that modified SPION interacts effectively with them. Results obtained with magnetic hyperthermia and biological studies confirm the promising properties of the hybrid towards future cancer cell treatment.

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