Multifunctional nanosystems sequentially regulating intratumor Fenton chemistry by remodeling the tumor microenvironment to reinforce chemodynamic therapy

Dong, Kai; Chen, Wenting; Zhao, Zhuangzhuang; Zhang, Ying; Wang, Pengchong; Wang, Ke; Xing, Jianfeng; Lu, Tingli; Dong, Yalin

doi:10.1016/j.bioadv.2022.212957

Cited by 8 publications

(5 citation statements)

References 43 publications

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“…Moreover, the cumulative release rate of FAM-Aptamer VEGF was always higher than that of TPE-2HPro in different buffers. These results indicated that the gradual degradation of PDA under acidic conditions accelerated the release of both probes in acidic buffers (pH values 5.0 and 6.5) . The release rate of FAM-Aptamer VEGF was faster than that of the TPE-2HPro since it was distributed on the surface of NPs, while the latter was loaded in the pores of MSN.…”

Section: Resultsmentioning

confidence: 90%

“…These results indicated that the gradual degradation of PDA under acidic conditions accelerated the release of both probes in acidic buffers (pH values 5.0 and 6.5). 54 The release rate of FAM-Aptamer VEGF was faster than that of the TPE-2HPro since it was distributed on the surface of NPs, while the latter was loaded in the pores of MSN. The results of in vitro stability and drug release tests showed that the coverage of the PDA layer could make MSN TH @PDA Apt stable in neutral blood circulation, thus reducing the probability of the probes' premature release.…”

Section: Stability Andmentioning

confidence: 99%

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Application of a Dual-Probe Coloading Nanodetection System in the Process Monitoring and Efficacy Assessment of Photodynamic Therapy: An In Vitro Study

Dong

Lei

Kang

et al. 2023

ACS Biomater. Sci. Eng.

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The oxygen-consuming property of photodynamic therapy (PDT) affects its effects and aggravates tumor hypoxia, thus upregulating the vascular endothelial growth factor (VEGF) to exacerbate tumor metastasis and lead to treatment failure. Therefore, it is necessary to monitor the dynamic changes in the factors related to PDT and tumor development trends in real time, thus helping to improve PDT efficiency. This study fabricated a fluorescent probe, TPE-2HPro, and a fluorescein-labeled aptamer probe, FAM-AptamerVEGF, to detect hydrogen peroxide (H2O2) and VEGF through the photoinduced electron-transfer effect and the specific affinity of the aptamer to VEGF, respectively. The two probes were loaded into the inner pores and absorbed on the surface of polydopamine coating-wrapped mesoporous silica nanoparticles (MSN@PDA) to construct the dual-probe-loaded system, MSNTH@PDAApt, which was kept stable in fetal bovine serum (FBS) solution and achieved pH-responsive release behavior, thus helping to increase the accumulation of the two probes in tumor cells. The dichloroacetic acid-mediated in vitro antitumor tests showed that the changing trends of H2O2 and VEGF levels were consistent with the results of related mechanism studies and could be monitored by MSNTH@PDAApt. The in vitro chlorin e6 (Ce6)-mediated PDT treatment demonstrated that when the illumination condition was 650 nm, 50 mW/cm2 for 10 min, cells were more inclined to metastasis and invasion rather than death due to a substantial increase in VEGF expression at the low Ce6 concentrations. With the increase of the Ce6 concentration, the growth of the H2O2 level gradually exceeded that of VEGF, and the reactive oxygen species (ROS)-mediated cell death dominated when the Ce6 concentration was about 2 times its IC50 values. Besides, hypoxia also affected the H2O2 and VEGF changes. These results demonstrated that MSNTH@PDAApt could precisely monitor and assess the tumor development trends during PDT treatment, thus helping improve the treatment effect.

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Section: Resultsmentioning

confidence: 90%

Section: Stability Andmentioning

confidence: 99%

Application of a Dual-Probe Coloading Nanodetection System in the Process Monitoring and Efficacy Assessment of Photodynamic Therapy: An In Vitro Study

Dong

Lei

Kang

et al. 2023

ACS Biomater. Sci. Eng.

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“…With the specific release of the CAI, CA IX was inhibited by BS, thus inducing intracellular H + accumulation to accelerate the Fenton reaction. Dong and co-workers reported a multifunctional nanosystem of TP I @PP CAI to remodel the TME and reinforce the in situ Fenton reaction, which was composed of the inner TP I micelles-loading iron-oxide nanoparticles (IONs) and the outer poly (dopamine-co-protocatechuic acid) (PDA-PA, PP) coating modified with the CAI [ 119 ]. Firstly, 4-(2-aminoethyl) benzenesulfonamide, a CA IX inhibitor, inhibited the overexpressed CA IX, thus leading to intracellular acidification.…”

Section: Different Strategies To Improve Cdt Performancementioning

confidence: 99%

The Application of Biomedicine in Chemodynamic Therapy: From Material Design to Improved Strategies

Cheng,

Li,

et al. 2023

Bioengineering

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Chemodynamic therapy (CDT) has garnered significant interest as an innovative approach for cancer treatment, owing to its notable tumor specificity and selectivity, minimal systemic toxicity and side effects, and absence of the requirement for field stimulation during treatment. This treatment utilizes nanocatalytic medicines containing transitional metals to release metal ions within tumor cells, subsequently initiating Fenton and Fenton-like reactions. These reactions convert hydrogen peroxide (H2O2) into hydroxyl radical (•OH) specifically within the acidic tumor microenvironment (TME), thereby inducing apoptosis in tumor cells. However, insufficient endogenous H2O2, the overexpressed reducing substances in the TME, and the weak acidity of solid tumors limit the performance of CDT and restrict its application in vivo. Therefore, a variety of nanozymes and strategies have been designed and developed in order to potentiate CDT against tumors, including the application of various nanozymes and different strategies to remodel TME for enhanced CDT (e.g., increasing the H2O2 level in situ, depleting reductive substances, and lowering the pH value). This review presents an overview of the design and development of various nanocatalysts and the corresponding strategies employed to enhance catalytic drug targeting in recent years. Additionally, it delves into the prospects and obstacles that lie ahead for the future advancement of CDT.

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“…Converting intratumoral H 2 O 2 into hydroxyl radicals ( OH) with high oxidation capability and cytotoxicity via the ironmediated Fenton reaction to kill tumor cells is an emerging strategy to achieve efficient CDT. [8][9][10][11] Unfortunately, limited H 2 O 2 concentration and iron-based catalytic efficiency in the TME greatly compromise the therapeutic efficacy of CDT. 12,13 On the one hand, researchers have proposed several strategies to increase intratumoral H 2 O 2 levels for an enhanced CDT effect, including stimulating endogenous H 2 O 2 production and direct H 2 O 2 delivery.…”

Section: Introductionmentioning

confidence: 99%

Fe-based cyclically catalyzing double free radical nanogenerator for tumor-targeted chemodynamic therapy

Wang,

Zhu,

Fan

et al. 2024

J. Mater. Chem. B

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Multifunctional nanosystems sequentially regulating intratumor Fenton chemistry by remodeling the tumor microenvironment to reinforce chemodynamic therapy

Cited by 8 publications

References 43 publications

Application of a Dual-Probe Coloading Nanodetection System in the Process Monitoring and Efficacy Assessment of Photodynamic Therapy: An In Vitro Study

Application of a Dual-Probe Coloading Nanodetection System in the Process Monitoring and Efficacy Assessment of Photodynamic Therapy: An In Vitro Study

The Application of Biomedicine in Chemodynamic Therapy: From Material Design to Improved Strategies

Fe-based cyclically catalyzing double free radical nanogenerator for tumor-targeted chemodynamic therapy

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