Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors

Zhang, Li; Liu, Yue; Huang, Haiyan; Xie, Hui; Zhang, Baozhu; Xia, Wujiong; Guo, Bing

doi:10.1016/j.addr.2022.114536

Cited by 83 publications

(43 citation statements)

References 410 publications

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“…There are many NIR-II fluorescent agents available, not only for efficient fluorescence imaging, but also for phototherapy ( Hu et al, 2021 ; Liu et al, 2021 ; Liu Y. et al, 2022 ; Zhang L. et al, 2022 ; Du et al, 2022 ; Lee et al, 2022 ; Nirmal et al, 2022 ; Shi et al, 2022 ; Sun et al, 2022 ). The level of deep tissue penetration using the NIR-II window significantly expands the application scope of phototherapy.…”

Section: Nir-ii Based Phototherapymentioning

confidence: 99%

Recent advances in NIR-II fluorescence based theranostic approaches for glioma

Ling¹,

Yao²

2022

Front. Chem.

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Gliomas are among the most common malignant tumors in the central nervous system and lead to poor life expectancy. However, the effective treatment of gliomas remains a considerable challenge. The recent development of near infrared (NIR) II (1000–1700 nm) theranostic agents has led to powerful strategies in diagnosis, targeted delivery of drugs, and accurate therapy. Because of the high capacity of NIR-II light in deep tissue penetration, improved spatiotemporal resolution can be achieved to facilitate the in vivo detection of gliomas via fluorescence imaging, and high contrast fluorescence imaging guided surgery can be realized. In addition to the precise imaging of tumors, drug delivery nano-platforms with NIR-II agents also allow the delivery process to be monitored in real-time. In addition, the combination of targeted drug delivery, photodynamic therapy, and photothermal therapy in the NIR region significantly improves the therapeutic effect against gliomas. Thus, this mini-review summarizes the recent developments in NIR-II fluorescence-based theranostic agents for glioma treatment.

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Section: Nir-ii Based Phototherapymentioning

confidence: 99%

Recent advances in NIR-II fluorescence based theranostic approaches for glioma

Ling¹,

Yao²

2022

Front. Chem.

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“…Importantly, BChl absorbs nearinfrared (NIR) light with maximum absorption peaks around 805 and 865 nm, suggesting that PSB may be an innovative candidate for novel photothermal reagents [30][31][32]. Therefore, we believe that PSB-based photothermal therapy with less invasiveness and a lower risk of drug resistance has great potential against infections by drug-resistant bacteria, which has not been reported to date [33][34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Bacteria-based multiplex system eradicates recurrent infections with drug-resistant bacteria via photothermal killing and protective immunity elicitation

et al. 2023

Biomater Res

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Background The high mortality associated with drug-resistant bacterial infections is an intractable clinical problem resulting from the low susceptibility of these bacteria to antibiotics and the high incidence of recurrent infections. Methods Herein, a photosynthetic bacteria-based multiplex system (Rp@Al) composed of natural Rhodopseudomonas palustris (Rp) and Food and Drug Administration-approved aluminum (Al) adjuvant, was developed to combat drug-resistant bacterial infections and prevent their recurrence. We examined its photothermal performance and in vitro and in vivo antibacterial ability; revealed its protective immunomodulatory effect; verified its preventative effect on recurrent infections; and demonstrated the system’s safety. Results Rp@Al exhibits excellent photothermal properties with an effective elimination of methicillin-resistant Staphylococcus aureus (MRSA). In addition, Rp@Al enhances dendritic cell activation and further triggers a T helper 1 (TH1)/TH2 immune response, resulting in pathogen-specific immunological memory against recurrent MRSA infection. Upon second infection, Rp@Al-treated mice show significantly lower bacterial burden, faster abscess recovery, and higher survival under near-lethal infection doses than control mice. Conclusions This innovative multiplex system, with superior photothermal and immunomodulatory effects, presents great potential for the treatment and prevention of drug-resistant bacterial infections. Graphical Abstract

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“…1 Organic particles such as liposomes, 2 small molecule, 3,4 and inorganic nanoparticles such as gold nanoparticles, [5][6][7][8] quantum dots, [9][10][11] graphene/carbon dots, [12][13][14] two-dimensional materials, 15,16 transition metal dichalcogenides (TMDs), 17,18 and MXenes 19,20 have been uti-lized to develop novel light-mediated cancer imaging and therapies. 21 The ability of these inorganic nanoparticles to convert near-infrared light (NIR) into heat is attracting the attention of researchers globally. 22 Biocompatible gold nanoparticles have been among the benchmark materials for photothermal therapy (PTT) because of their inert nature and excellent light-to-heat conversion efficiency.…”

Section: Introductionmentioning

confidence: 99%