Multifunctional near infrared-emitting long-persistence luminescent nanoprobes for drug delivery and targeted tumor imaging

Shi, Junpeng; Sun, Xia; Li, Jinlei; Man, Huizi; Shen, Jing; Yu, Yanke; Zhang, Hongwu

doi:10.1016/j.biomaterials.2014.10.033

Cited by 171 publications

(116 citation statements)

References 35 publications

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“…This method results in the formation of a MSNs@PLNPs composite material, as it is the case of SiO 2 @SrMgSi 2 [123] uniform nanospheres. Physical techniques, mainly laser-based strategies, have also been reported for the preparation of PLNPs.…”

Section: +mentioning

confidence: 99%

“…For this, the NPs have to be stabilized in ethanol media with agents such as PVP of PEG-based ligands [158,159]. This is by far the most commonly used strategy for the functionalization of PLNPs with silica that is used in bioassays [118,119,123,160]. For the silica encapsulation of hydrophobic NPs, a reverse microemulsion strategy is commonly used.…”

Section: Functionalization Strategiesmentioning

confidence: 99%

“…they participate in the mechanism with changes in their number of oxidation), or they just emit light through a controlled and slow ET from the host material [281,282]. The most common matrices used for persistent luminescent materials are based on silicate, aluminate, gallogermanate and gallates [47,118,119,123,283,284].…”

Section: Luminescent Propertiesmentioning

confidence: 99%

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Rare earth based nanostructured materials: synthesis, functionalization, properties and bioimaging and biosensing applications

et al. 2017

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Abstract:Rare earth based nanostructures constitute a type of functional materials widely used and studied in the recent literature. The purpose of this review is to provide a general and comprehensive overview of the current state of the art, with special focus on the commonly employed synthesis methods and functionalization strategies of rare earth based nanoparticles and on their different bioimaging and biosensing applications. The luminescent (including downconversion, upconversion and permanent luminescence) and magnetic properties of rare earth based nanoparticles, as well as their ability to absorb X-rays, will also be explained and connected with their luminescent, magnetic resonance and X-ray computed tomography bioimaging applications, respectively. This review is not only restricted to nanoparticles, and recent advances reported for in other nanostructures containing rare earths, such as metal organic frameworks and lanthanide complexes conjugated with biological structures, will also be commented on.

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Section: +mentioning

confidence: 99%

Section: Functionalization Strategiesmentioning

confidence: 99%

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Rare earth based nanostructured materials: synthesis, functionalization, properties and bioimaging and biosensing applications

et al. 2017

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Section: Long-lasting Phosphorescencementioning

confidence: 99%

“…LLP is of particular interest for both in vitro biodetection and in vivo bioimaging, because the PLNPs can be excited before signal acquisition, which allows for real-time monitoring of the target analytes for more than 1 h without the need for any external illumination. Such a removal of in situ excitation in the signal analysis process provides a unique solution to circumvent the interference from tissue autofluorescence and the phototoxicity of the NPs, thereby offering high signal-to-noise ratio and sensitivity for biosensing [174].In order to interpret the occurrence of LLP, various mechanisms ranging from basic conceptual models to complex systems have been proposed in the past decades [175]. It is generally accepted that upon excitation, charge carriers could be caught by the so called "traps", which are long-lived energy levels inside the band gap of the host material.…”

mentioning

confidence: 99%

Inorganic lanthanide nanoprobes for background-free luminescent bioassays

Huang

Zheng

et al. 2015

Sci. China Mater.

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Luminescent bioassay techniques have been widely adopted in a variety of research and medical institutions. However, conventional luminescent bioassays utilizing traditional bioprobes like organic dyes and quantum dots often suffer from the interference of background noise from scattered lights and autofluorescence from biological matrices. To eliminate this disadvantage, the use of inorganic lanthanide (Ln 3+ )-doped nanoparticles (NPs) is an excellent option in view of their superior optical properties, such as the long-lived downshifting luminescence, near-infrared triggered anti-Stokes upconverting luminescence and excitation-free persistent luminescence. In this review, we summarize the latest advances in the development of inorganic Ln 3+ -doped NPs as sensitive luminescent bioprobes from their fundamental physicochemical properties to biodetection, including the chemical synthesis, surface functionalization, optical properties and their promising applications for background-free luminescent bioassays. Future efforts and prospects towards this rapidly growing field are also proposed. INTRODUCTIONSensitive and specific bioassay of trace amount of target analytes is essential for a variety of biomedical applications ranging from pharmaceutical preparation to disease diagnosis and therapy [1][2][3]. Among various bioassay methods, luminescent bioassay has received particular attention because of its high sensitivity and good specificity [4,5]. Conventional luminescent bioassay techniques such as enzyme-linked immunosorbent assay (ELISA), time-resolved (TR) fluoroimmunoassay (TRFIA), Förster resonance energy transfer (FRET) and TR-FRET assays have laid the foundation for many modern clinical applications [6][7][8][9][10][11]. However, these bioassays are impeded by the availability of traditional bioprobes like organic dyes, lanthanide (Ln 3+ ) chelates and quantum dots (QDs). The use of these bioprobes has a number of limitations. Organic dyes commonly possess poor photochemical stability and suffer from serious photobleaching [12]. The applicability of QDs is compromised by photoblinking and high toxic- ity of heavy metal elements like cadmium and selenium, especially for in vivo biosensing [13,14]. Moreover, both organic dyes and QDs may induce high background noise and considerable photodamage to the biological samples under ultraviolet (UV) excitation, which deteriorates their detection sensitivity for bioassays [15,16]. Although such background noise can be suppressed by the technique of TR photoluminescence (PL) through the use of the longlived luminescence of Ln 3+ -chelates, the poor photochemical stability, long-term toxicity and high cost of Ln 3+ -chelates remain a major issue [17]. These concerns fuel a crucial demand for the development of a new generation of luminescent bioprobes to circumvent the limitations of traditional ones.Recently, with the explosion of nanoscience and nanotechnology, there is a growing dedication towards the development of diverse luminescent nanoprobes for biodetection ...

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Luminescent Ions in Advanced Composite Materials for Multifunctional Applications

Bai

Tsang

Hao

2016

Adv Funct Materials

223

136

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Luminescent ions doped materials have been widely applied in many areas, both scientifi c research and practical fi elds. Recently, incorporating luminescent ions and advanced materials into versatile and multifunctional systems seems to be a tendency, motivated by the stimulating desires of fundamental studies and technological applications. This feature article provides a general overview of the myriad of luminescent ions-based advanced composite materials recently investigated. It is demonstrated that the improved or additional properties may be achieved via implementing a strategy of incorporating luminescent ions (lanthanide, transition and main group metal ions) into various types of materials, such as fl exible polymers, two-dimensional atomically thin layers, porous materials, and so on. We outline the design principles, synthesis and processing of various systems joined by luminescent ions doped phosphors. A number of recent works indicate that those novel composite materials allow one to conceive and develop multifunctional applications in a broad area, including optoelectronics, photonics, clean energy, biomedicine, and new types of sensors. Lastly, some challenging issues are discussed and potential directions are suggested for further developing advanced composite materials incorporated with luminescent ions.

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Multifunctional near infrared-emitting long-persistence luminescent nanoprobes for drug delivery and targeted tumor imaging

Cited by 171 publications

References 35 publications

Rare earth based nanostructured materials: synthesis, functionalization, properties and bioimaging and biosensing applications

Rare earth based nanostructured materials: synthesis, functionalization, properties and bioimaging and biosensing applications

Inorganic lanthanide nanoprobes for background-free luminescent bioassays

Luminescent Ions in Advanced Composite Materials for Multifunctional Applications

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