Multifunctional O-phenanthroline silver(I) complexes for antitumor activity against colorectal adenocarcinoma cells and antimicrobial properties by multiple mechanisms

Niu, Zong‐ling; Zhou, Sihan; Wu, Yuanyuan; Wu, Tian-Tian; Liu, Qi-Shuai; Zhao, Qi‐Hua; Ren, Xinrong; Jin, Hua; Xie, Ming‐Jin

doi:10.1016/j.jinorgbio.2023.112293

Journal of Inorganic Biochemistry

2023

DOI: 10.1016/j.jinorgbio.2023.112293

|View full text |Cite

Multifunctional O-phenanthroline silver(I) complexes for antitumor activity against colorectal adenocarcinoma cells and antimicrobial properties by multiple mechanisms

Zong‐ling Niu

Sihan Zhou

Yuanyuan Wu

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Bis(thiosemicarbazide)gallium(III) Complexes as Potent Anticancer Agents by ROS Induction and Mitochondrial Pathway Activation

Zhou,

Wu,

Yang

et al. 2024

Applied Organom Chemis

View full text Add to dashboard Cite

A series of bis(thiosemicarbazide)gallium (III) complexes were synthesized and characterized by infrared spectroscopy, mass spectrometry, nuclear magnetic resonance, single‐crystal x‐ray crystallography, and density functional theory (DFT) calculation. The cytotoxicity of these gallium(III) complexes (CP 1–4) was subsequently evaluated against HCT‐116, HeLa, MDA‐MB‐231, and A549 cancer cell lines, as well as the normal cell line LO2, by MTT assays. The results indicated that CP‐1 displayed potent inhibitory effects against human colorectal cancer cells (HCT‐116) (IC50 = 0.03 ± 0.01) and human breast cancer cells (MDA‐MB‐231) (IC50 = 0.02 ± 0.01), significantly outperforming cisplatin. Moreover, CP‐2 exhibited notable selectivity towards MDA‐MB‐231 cells (IC50 = 5.01 ± 0.40) with minimal toxicity towards normal cells. Mechanistic studies revealed that treatment with CP 1–2 led to elevated intracellular reactive oxygen species (ROS) levels, resulting in cell cycle arrest at different phases. Specifically, CP‐1 induced G2/M phase arrest, inhibiting cancer cell proliferation, whereas CP‐2 hindered DNA synthesis (S phase) to impede cell proliferation. Furthermore, both CP‐1 and CP‐2 caused a reduction in mitochondrial membrane potential, activating the mitochondrial apoptotic pathway and inducing apoptosis in cancer cells. Molecular docking experiments demonstrated strong interactions between CP 1–2 and protein disulfide isomerase (PDI) at the molecular level. These findings suggest that CP‐1 and CP‐2 serve as potential anticancer agents, particularly showing promising potential in the treatment of breast cancer.

show abstract

Bis(thiosemicarbazide)gallium(III) Complexes as Potent Anticancer Agents by ROS Induction and Mitochondrial Pathway Activation

Zhou,

Wu,

Yang

et al. 2024

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Multifunctional O-phenanthroline silver(I) complexes for antitumor activity against colorectal adenocarcinoma cells and antimicrobial properties by multiple mechanisms

Cited by 1 publication

References 69 publications

Bis(thiosemicarbazide)gallium(III) Complexes as Potent Anticancer Agents by ROS Induction and Mitochondrial Pathway Activation

Bis(thiosemicarbazide)gallium(III) Complexes as Potent Anticancer Agents by ROS Induction and Mitochondrial Pathway Activation

Contact Info

Product

Resources

About