Multifunctional organic monolayer-based coatings for implantable biosensors and bioelectronic devices: Review and perspectives

Patel, Taral; Huang, Jie; Krukiewicz, Katarzyna

doi:10.1016/j.biosx.2023.100349

Cited by 6 publications

(4 citation statements)

References 144 publications

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“…Combined with modern data analysis, this can yield unprecedented physiological insight that can be used for diagnostic, therapeutic, and health management well beyond current abilities. 767,768 In implantable systems, the data handling can be accomplished through three different schemes, as shown in Figure 26: in-body inference, wearable inference, and external inference. Each of these computation locations has its advantages and disadvantages.…”

Section: Distributed Artificially Intelligent Computationmentioning

confidence: 99%

“…The high fidelity of sensor information achieved through improved biointerfaces (see Section “Biointegration Strategies for Implantable Devices”) coupled with continuous operation afforded by power casting (see Section “Power Casting Techniques”) and power harvesting (see Section “Power Harvesting Techniques”) enables high sampling rates that result in large data sets that are unachievable with contemporary technologies. Combined with modern data analysis, this can yield unprecedented physiological insight that can be used for diagnostic, therapeutic, and health management well beyond current abilities. , …”

Section: Infrastructure Integrationmentioning

confidence: 99%

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Wireless Battery-free and Fully Implantable Organ Interfaces

Bhatia,

Hanna,

Stuart

et al. 2024

Chem. Rev.

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Advances in soft materials, miniaturized electronics, sensors, stimulators, radios, and battery-free power supplies are resulting in a new generation of fully implantable organ interfaces that leverage volumetric reduction and soft mechanics by eliminating electrochemical power storage. This device class offers the ability to provide high-fidelity readouts of physiological processes, enables stimulation, and allows control over organs to realize new therapeutic and diagnostic paradigms. Driven by seamless integration with connected infrastructure, these devices enable personalized digital medicine. Key to advances are carefully designed material, electrophysical, electrochemical, and electromagnetic systems that form implantables with mechanical properties closely matched to the target organ to deliver functionality that supports high-fidelity sensors and stimulators. The elimination of electrochemical power supplies enables control over device operation, anywhere from acute, to lifetimes matching the target subject with physical dimensions that supports imperceptible operation. This review provides a comprehensive overview of the basic building blocks of battery-free organ interfaces and related topics such as implantation, delivery, sterilization, and user acceptance. State of the art examples categorized by organ system and an outlook of interconnection and advanced strategies for computation leveraging the consistent power influx to elevate functionality of this device class over current battery-powered strategies is highlighted.

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Section: Distributed Artificially Intelligent Computationmentioning

confidence: 99%

Section: Infrastructure Integrationmentioning

confidence: 99%

Wireless Battery-free and Fully Implantable Organ Interfaces

Bhatia,

Hanna,

Stuart

et al. 2024

Chem. Rev.

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“…Moreover, leaching specific molecules from organic materials into the biological environment may compromise the biosensor's accuracy and specificity. On the other hand, biofouling challenges encompass the non-specific binding of biomolecules, proteins, or cells to the biosensor surface, thereby generating unwanted signals and reducing sensitivity [262]. The accumulation of biofilm or organic material on the sensor surface can alter the electrical properties of the organic material, thus leading to a decline in sensor performance over time.…”

Section: Biocompatibility Biofouling and Cross-sensitivitymentioning

confidence: 99%

Organic Electronics in Biosensing: A Promising Frontier for Medical and Environmental Applications

Kaushal,

Raut,

Kumar

2023

Biosensors

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The promising field of organic electronics has ushered in a new era of biosensing technology, thus offering a promising frontier for applications in both medical diagnostics and environmental monitoring. This review paper provides a comprehensive overview of organic electronics’ remarkable progress and potential in biosensing applications. It explores the multifaceted aspects of organic materials and devices, thereby highlighting their unique advantages, such as flexibility, biocompatibility, and low-cost fabrication. The paper delves into the diverse range of biosensors enabled by organic electronics, including electrochemical, optical, piezoelectric, and thermal sensors, thus showcasing their versatility in detecting biomolecules, pathogens, and environmental pollutants. Furthermore, integrating organic biosensors into wearable devices and the Internet of Things (IoT) ecosystem is discussed, wherein they offer real-time, remote, and personalized monitoring solutions. The review also addresses the current challenges and future prospects of organic biosensing, thus emphasizing the potential for breakthroughs in personalized medicine, environmental sustainability, and the advancement of human health and well-being.

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“…The design and implementation of functional coatings is nowadays a topic of active research in a variety of healthrelated applications such as tissue engineering, bioelectronic devices, prevention of microbial proliferation, control of oxidative stress and inflammation, as well as medical diagnostics and therapy (theranostics) [1][2][3][4] and particularly in nanomedicine, in which the functionalization of nanostructures is of crucial importance to biocompatibility, blood circulation time and the ability to cross biological barriers. [5][6][7][8] Other fields of application include food packaging, material surfaces and interfaces modifications e. g., corrosion inhibition, metal removal through functionalized membranes till catalysis and energy applications.…”

Section: Introduction: Functional Coatingsmentioning

confidence: 99%

Multifunctional coatings hinging on the catechol/amine interplay

Alfieri,

Panzella,

Napolitano

2023

Eur J Org Chem

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Design and implementation of functional coatings is a topic of active research in a variety of health‐related applications, most of which require wet adhesion. The powerful wet adhesion of mussel byssus proteins rich in DOPA and lysine residues provided a clue to realize that the combination of a catechol and an amine component has a specific role in the interfacial adhesion. From this natural model, polydopamine (PDA)‐based coatings have been developed that result from the oxidative polymerization of dopamine combining the catechol and amine functionalities in the same molecule. Covalent interactions resulting from Michael‐type addition or Schiff‐base formation of the polymeric products from dopamine oxidation as well as non‐covalent π‐stacking and cation‐π interactions exemplify the diverse mode of catechol/amine interplay that have been identified as responsible of the adhesion and cohesion properties of PDA. In the last decade coatings inspired to the same chemistry but using different starting materials have been explored particularly catechols of natural origin and different amine components, while mechanistic studies with model compounds have allowed to rationalize the structural requirements for adhesion and to expand the potential of these functional coatings.

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Multifunctional organic monolayer-based coatings for implantable biosensors and bioelectronic devices: Review and perspectives

Cited by 6 publications

References 144 publications

Wireless Battery-free and Fully Implantable Organ Interfaces

Wireless Battery-free and Fully Implantable Organ Interfaces

Organic Electronics in Biosensing: A Promising Frontier for Medical and Environmental Applications

Multifunctional coatings hinging on the catechol/amine interplay

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