Multifunctional pentacyclic triterpenoids as adjuvants in cancer chemotherapy: a review

Kamble, S. M.; Goyal, Sameer N.; Patil, Chandragouda R.

doi:10.1039/c4ra02784a

Cited by 49 publications

(36 citation statements)

References 177 publications

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“…Several investigators have reviewed specifically various classes of naturally occurring triterpenoids as potential anticancer agents (e.g., [5,[8][9][10][11][12][13][14][15][16]). The interest of the present authors on this same issue has been stimulated as a result of 2 long-standing collaborative multidisciplinary projects funded sequentially by the U. S. National Cancer Institute, in which numerous triterpenoids isolated from tropical plants collected in several continents were evaluated biologically [17,18].…”

Section: Natural Product Triterpenoids and Their Semi-synthetic Derivmentioning

confidence: 99%

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Natural Product Triterpenoids and Their Semi-Synthetic Derivatives with Potential Anticancer Activity

Ren

Kinghorn

2019

Planta Med

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Triterpenoids are distributed widely in higher plants and are of interest because of their structural diversity and broad range of bioactivities. In particular, there is a very large literature on the propensity of a variety of triterpenoids to act as potential anticancer agents. In the present review, the anticancer potential is summarized for naturally occurring triterpenoids and their semi-synthetic derivatives, including examples of lupane-, oleanane-, ursane-, and cucurbitane-type pentacyclic triterpenoids, along with dammarane-type tetracyclic triterpenes including ginsenosides and their sapogenins and dichapetalins, which have been characterized as antitumor leads from higher plants. Preliminary structure-activity relationships and reported mechanisms of the antineoplastic-related activity are included. Prior studies for triterpenoids of plant origin are supportive of additional work being conducted on the more detailed biological and mechanistic evaluation for the progression of this type of natural products as possible cancer chemotherapeutic agents.

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Section: Natural Product Triterpenoids and Their Semi-synthetic Derivmentioning

confidence: 99%

“…▶ Fig. 3 Structures of (+)-ursolic acid (11) and its semi-synthetic analogues (12)(13)(14)(15)(16) with potential anticancer activity.…”

Section: Ursane-type Triterpenoidsmentioning

confidence: 99%

Natural Product Triterpenoids and Their Semi-Synthetic Derivatives with Potential Anticancer Activity

Ren

Kinghorn

2019

Planta Med

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“…This ability makes them interesting for the development of new antineoplastics agents (Salvador et al, 2017;Ren and Kinghorn, 2019). In addition, pentacyclic triterpenes present selective cytotoxicity, capable to distinguish between tumor and non-tumorcells, possibly associated with their ability to modulate tumor microenvironment and the immune system (Kamble et al, 2014). Therefore, these compounds have low toxicity in normal cells and high efficiency on cancer cells, reported in many in vitro and in vivo studies, including clinical trials (Gill et al, 2016;Zhang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cytotoxic activity of triterpenes from Clusia studartiana

Brito¹,

Carvalho²,

Silva³

et al. 2019

J. Med. Plants Res.

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Family Clusiaceae is spread throughout tropical as well as temperate zones, presenting many triterpenes, reported as selective antitumoral agents. The aim of this study is to isolate and identify triterpenes from Clusia studartiana C. M. Vieira & Gomes da Silva and evaluate their cytotoxicity in melanoma (SKMEL 28) and myeloid leukemia (K562) cell lines. Thus, the hexanic extract was processed by phytochemical methods to isolate and purify the pentacyclic triterpenes: 3-oxo-friedelin (1), 3-βhydroxy-friedelin (2) and 3-oxo-olean-12-en-28-oic-acid (3), identified by spectroscopic methods. Cytotoxicity was evaluated by MTT assay, apoptosis/necrosis by Annexin V/PI, caspase activity by FLICA in flow cytometry and P-gp modulation was measured by interference in the efflux of Rhodamine 123. From the results, triterpenes 2 and 3 showed inhibitory effect in K562 cells proliferation, and only the compound 3 was able to increase percentage of AnnexinV + PI in cells (p<0.05), with 40% increase in caspase 3/7 + cells and showed inhibition on P-gp activity.

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“…1 Several reviews have covered the anticancer effects of triterpenoids. [2][3][4][5][6][7][8][9] Other activities that have been highlighted include anti-HIV, [10][11][12] antiinammatory, 13 antiviral 6 and against neurodegenerative disorders. 14 As many of the active compounds are saponins there has been an interest in their synthesis 15 and biosynthesis.…”

Section: Introductionmentioning

confidence: 99%

Triterpenoids

Hill

Connolly

2018

Nat. Prod. Rep.

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Covering 2014. Previous review: Nat. Prod. Rep., 2017, 34, 90-122This review covers the isolation and structure determination of triterpenoids reported during 2014 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, isomalabaricanes and saponins; 374 references are cited.

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Multifunctional pentacyclic triterpenoids as adjuvants in cancer chemotherapy: a review

Abstract: The protective adjuvants in chemotherapy.

Cited by 49 publications

References 177 publications

Natural Product Triterpenoids and Their Semi-Synthetic Derivatives with Potential Anticancer Activity

Natural Product Triterpenoids and Their Semi-Synthetic Derivatives with Potential Anticancer Activity

Evaluation of cytotoxic activity of triterpenes from Clusia studartiana

Triterpenoids

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