Multifunctional Plasma-Polymerized Film: Toward Better Anticorrosion Property, Enhanced Cellular Growth Ability, and Attenuated Inflammatory and Histological Responses

Abstract

Over the past few decades, plasma surface modification technique has been widely used to selectively improve surface properties and biocompatibility of materials. In this paper, at first a simple and effective method for the deposition of plasma-polymerized allylamine films onto 316L stainless steel (SS) from an allylamine/nitrogen gas mixture was developed. These amine-rich films were characterized by grazing incidence attenuated total reflection Fourier transform infrared spectroscopy (GATR-FTIR) and X-ray photoelectron spectroscopy (XPS), and the anticorrosion properties were demonstrated by electrochemical analysis. Micro-BCA and quartz crystal microbalance with dissipation (QCM-D) results showed that the higher density of amine groups of the allylamine-nitrogen plasma-polymerized film contributes to more serum protein adsorption which may enhance the adhesion and growth of cells on biomaterials. The in vitro and in vivo anti-inflammatory evaluation was performed and it has been confirmed that these nitrogen-rich surfaces could inhibit the activation of macrophages by down-regulation of the pro-inflammatory cytokines TNF-α and IL-6, and exhibit acceptable tissue-compatibility. It was found that with the help of nitrogen, plasmapolymerized allylamine films presented superior biological properties and provided a high potential application in surface modification of biomedical substrate with desirable clinical performance.

Enhancing tissue integration and angiogenesis of a novel nanocomposite polymer using plasma surface polymerisation, an in vitro and in vivo study

“…Using NH 2 and COOH functional modification of materials with PSP is by far the most common method of surface modification to improve cell adhesion and proliferation. There are only a few studies on the in vivo analysis [34][35][36] of these functional groups and thus their long term effects on tissue integration and angiogenesis still remain unclear. This study aims to fill this gap in the research.…”

“…To date only a few studies have documented the effect of plasma modification in vivo. [34][35][36] Recently published work by Valence et al 35 looked at the in vivo effects of air plasma modification biodegradable vascular grafts and showed enhance vascularisation for their polycaprolactone scaffold. However, there are only two relevant studies published recently looking at the effects of amine and carboxyl functional modifications of polymers in vivo.…”

Probing cell metabolism on insulin like growth factor(IGF)‐1/tumor necrosis factor(TNF)‐α and chargeable polymers co‐immobilized conjugates

“…Cell senescence had a known association with marked alterations in cellular metabolism (Locasale & Cantley, 2011). The alteration was ideally followed using metabolomics, as this approach permitted the unbiased and simultaneous detection of a wide range of cellular metabolites in response to a stimulus (Qi et al., 2015).…”

The Surface Modification Methods for Constructing Polymer-Coated Stents

“…Moreover, the method exhibits the potential to tailor polymer coating to meet specific needs [33]. For example, it is easy for plasma technique to modulate the coating chemical composition including surface carboxyl, hydroxyl, amine, or nitrogen-rich functional groups, while the functions of the underlying implant materials are not damaged through an optimal selection of gaseous mixtures [33,[37][38][39].…”