Multifunctional Plasmonic Shell–Magnetic Core Nanoparticles for Targeted Diagnostics, Isolation, and Photothermal Destruction of Tumor Cells

Abstract

Cancer is the greatest challenge in human healthcare today. Cancer causes 7.6 million deaths and economic losses of around 1 trillion dollars every year. Early diagnosis and effective treatment of cancer are crucial for saving lives. Driven by these needs, we report the development of a multifunctional plasmonic shell–magnetic core nanotechnology-driven approach for the targeted diagnosis, isolation, and photothermal destruction of cancer cells. Experimental data show that aptamer-conjugated plasmonic/magnetic nanoparticles can be used for targeted imaging and magnetic separation of a particular kind of cell from a mixture of different cancer cells. A targeted photothermal experiment using 670-nm light at 2.5 W/cm2 for 10 minutes resulted selective irreparable cellular damage to most of the cancer cells. We also showed that the aptamer-conjugated magnetic/plasmonic nanoparticle-based photothermal destruction of cancer cells is highly selective. We discuss the possible mechanism and operating principle for the targeted imaging, separation, and photothermal destruction using magnetic/plasmonic nanotechnology.

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

“…25,26 The capability to perform more than one simple task is one of the most promising aspects of bionanotechnology, i.e., the so-called multifunctional NPs. The examples in the literature about multifunctional NPs are manifold, 15,[27][28][29][30][31] and the combinations of molecules and NPs are very diverse. Figure 1 schematically depicts several possible functionalities, which are categorized depending on the NPs' design.…”

“…MRI contrast is given by the distinct magnetic relaxation processes of the nuclear spins of hydrogen atoms in water and fat, the major hydrogen-containing components of the human body. Other elements can also be used, including 3 He, 13 C, 19 F, 17 O, 23 Na, 31 P, and 129 Xe. MRI is noninvasive, nondestructive, and allows for full-body three-dimensional reconstruction with high spatial resolution and excellent soft tissue contrast.…”

Functional Inorganic Nanohybrids for Biomedical Diagnosis

“…Figure 8 shows the use of S6 aptamer-conjugated plasmonic-magnetic Au-Fe3O4 nanohybrids for the targeted diagnosis, isolation, and photothermal destruction of human breast cancer cells. [72] Cy3-modified S6 aptamers were attached to magnetic/plasmonic nanoparticles through -SH linkage. In the multifunctional nanoparticles, gold plasmonic shells were used as both a photothermal agent and a nanoplatform; the magnetic core was used for cell isolation.…”

Исследования свойств наночастиц Ag/FeСo/Ag типа ядро/ оболочка/оболочка

“…Значительное внимание исследователей в последние годы привлекают магнитные плазмонно-резонансные (ПР) гибридные наноразмерные частицы (ГНЧ), потому что весьма перспективны для широкого круга примене-ний, в том числе в биомедицине для адресной доставки лекарств, терапии рака, усиления контрастности томо-графических снимков [1][2][3][4], магнитной сепарации, обра-ботки изображений [5]. Адресная доставка с помощью ПР ГНЧ основана на том, что их можно подвергать биоконъюгации, т. е. прикреплять к ним биомолекулы (ДНК/РНК, белки, олигосахариды и др.)…”