Multifunctional poly(d,l-lactide-co-glycolide)/montmorillonite (PLGA/MMT) nanoparticles decorated by Trastuzumab for targeted chemotherapy of breast cancer

Sun, Bing; Ranganathan, Balu; Feng, Si‐Shen

doi:10.1016/j.biomaterials.2007.09.038

Cited by 253 publications

(121 citation statements)

References 47 publications

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“…Polyester-based materials, such as poly(lactide-co-glycolide) (PLGA), were once used solely for their controllable biodegradation capabilities but are now being modified, both chemically and physically, in order to meet demanding device requirements. PLGA materials are now not only used as delivery vehicles for drugs and other therapies but also;in manipulated forms;to target cancer, 1 molded into load-bearing geometries such as a screw, 2 to image targeted areas, 3 and can be switched from a temporary shape into a permanent shape through heat or other stimulation. 4,5 This last property, called shape memory, allows for unique possibilities.…”

Section: Introductionmentioning

confidence: 99%

“…Supporting Information Available: (1) Dynamic mechanical analysis and wide-angle X-ray scattering data showing evidence for crystallization of the P(10)-PLGA4-net conetwork; (2) consecutive shape memory cycles around the glass transition temperature of PLGA4-net; (3) small-angle X-ray of P-PLGA4-net during a 1-way shape memory cycle. This material is available free of charge via the Internet at http://pubs.acs.org.…”

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confidence: 99%

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PLGA−POSS End-Linked Networks with Tailored Degradation and Shape Memory Behavior

et al. 2009

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Biodegradable PLGA oligomers were synthesized to feature a hybrid organic-inorganic moiety, POSS, incorporated at the center of each chain by using it as the ring-opening initiator. After end-capping with vinyl groups, the macromers were photocured into networks with POSS content ranging from 10 to 41 wt %. Increasing POSS inclusion increased the crystallinity of the network while decreasing the degradation rate due to its hydrophobic and nonhydrolyzable properties. It was found that co-curing PLGA oligomers with and without POSS in the backbone could be utilized to create networks with a reduced POSS loading level, at a given cross-link density, allowing tuned crystallinity. Hydrolytic degradation of the co-cured networks was slower than for the PLGA homonetwork but still led to complete degradation after 14 weeks in PBS buffer at 37°C. The networks exhibited versatile shape memory properties, exploiting the combination of covalent cross-linking and the glass transition, POSS-phase melting temperature, or both as the shape-switching trigger. Using the glass transition was found to yield the best shape fixing, while the best recovery percentages (∼100%) were achieved when the melting transition was used. One network, with 24 wt % POSS, was able to be fixed in a temporary shape by POSS crystallization and to largely preserve this shape during degradation. After 4 weeks and 60% mass loss, 50% of the initial deformation still remained while the PLGA network (shape fixed through T g ) had recovered fully. Our findings are expected to impact future design of biodegradable polymers with shape memory, having revealed the precise tuning of properties possible through controlled placement of a crystallizable and hydrophobic moiety in the polymer network chain.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

PLGA−POSS End-Linked Networks with Tailored Degradation and Shape Memory Behavior

et al. 2009

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“…Most importantly, the therapeutic effects of the paclitaxel-loaded nanoparticles with HER2 antibodies could be up to 12 times higher than that of the untargeted nanoparticles. [25] While we have highlighted some successful examples and effective means of utilizing physical conjugation between nanomaterials and antibodies, there are many limitations associated with the physical adsorption approach. [76] Hydrophobic interactions may result in change to the 3D conformation of antibodies, thereby resulting in irreversible denaturation.…”

Section: Antibody-conjugated Nanoparticle Using Physical Adsorptionmentioning

confidence: 99%

Recent Advances in the Generation of Antibody–Nanomaterial Conjugates

Sivaram

Wardiana

Howard

et al. 2017

Adv Healthcare Materials

101

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Targeted nanomedicines have significantly changed the way new therapeutics are designed to treat disease. Central to successful therapeutics is the ability to control the dynamics of protein–nanomaterial interactions to enhance the therapeutic effect of the nanomedicine. The aim of this review is to illustrate the diversity and versatility of the conjugation approaches involved in the synthesis of antibody–nanoparticle conjugates, and highlight significant new advances in the field of bioconjugation. Such nanomedicines have found utility as both advanced therapeutic agents, as well as more complex imaging contrast agents that can provide both anatomical and functional information of diseased tissue. While such conjugates show significant promise as next generation targeted nanomedicines, it is recognized that there are in fact no clinically approved targeted therapeutics on the market. This fact is reflected upon within this review, and attempts are made to draw some reasoning from the complexities associated with the bioconjugation chemistry approaches that are typically utilized. Present trends, as well as future directions of next generation targeted nanomedicines are also discussed.

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“…Dessa forma, com engenhosidade e combinando conhecimento de diferentes áreas, consegue-se aprimorar a estratégia de drogas alvo-específicas. [13][14][15][16] Os carregadores virais têm sido reportados como os mais eficientes, mas apresentam muitos efeitos colaterais, tais como respostas imunes e mutação dos genes. Os carregadores catiônicos (lipídios e polímeros) podem evitar tais problemas, porém usualmente são muito tóxicos para a célula.…”

Section: Introductionunclassified

Hidróxidos duplos lamelares: nanopartículas inorgânicas para armazenamento e liberação de espécies de interesse biológico e terapêutico

Cunha¹,

Ferreira²,

Constantino³

et al. 2010

Quím. Nova

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Recebido em 11/12/08; aceito em 1/7/09; publicado na web em 27/11/09 LAYERED DOUBLE HYDROXIDES: INORGANIC NANOPARTICLES FOR STORAGE AND RELEASE OF SPECIES OF BIOLOGICAL AND THERAPEUTIC INTEREST. Studies about the inorganic nanoparticles applying for non-viral release of biological and therapeutic species have been intensified nowadays. This work reviews the preparation strategies and application of layered double hydroxides (LDH) as carriers for storing, carrying and control delivery of intercalated species as drugs and DNA for gene therapy. LDH show low toxicity, biocompatibility, high anion exchange capacity, surface sites for functionalization, and a suitable equilibrium between chemical stability and biodegradability. LDH can increase the intercalated species stability and promote its sub-cellular uptake for biomedical purposes. Concerning the healthy field, LDH have been evaluated for clinical diagnosis as a biosensor component.Keywords: layered double hydroxides; inorganic carriers; drug release. INTRODUÇÃOO desenvolvimento de materiais híbridos é um campo de pesquisa que vem apresentando um desenvolvimento considerável nos últimos anos, devido principalmente ao fato de combinar o conhecimento tradicional com as novas abordagens e as modernas tecnologias. Esse desenvolvimento tem como objetivo atender à crescente demanda por novos materiais multifuncionais, com variadas aplicações em Física, Química, Biologia, Agricultura e Medicina. Particularmente, merece destaque o número de trabalhos que tratam da utilização de nanopartículas como cápsulas de armazenamento ou carregadores de espécies de interesse biológico e terapêutico. 1-3Diversos sistemas para liberação controlada de drogas têm sido engendrados e descritos, com suas vantagens e desvantagens comparadas, podendo ser classificados em quatro grupos principais: carregadores virais, compostos catiônicos orgânicos, proteínas recombinantes e nanopartículas inorgânicas. Exemplos recentes incluem: pontos quânticos (quantum dots) ou nanocompósitos magnético-fluorescentes; 4,5 géis poliméricos; 6,7 nanotubos de carbono ou sílica funcionalizados; 8 cápsulas multilamelares de polieletrólitos; 9 nanopartículas de ouro 10,11 e hidróxidos duplos lamelares (HDL). 12A Figura 1 mostra alguns exemplos de espécies nanoparticuladas de interesse na área médica. Particularmente, a busca por terapias antitumorais novas e racionais, aliadas às técnicas de diagnóstico mais seguras, envolve o planejamento e a obtenção de drogas ou fármacos alvo-específicos, isto é, que tenham alta especificidade para determinada biomolécula ou componente celular, podendo então serem transportados e liberados apenas em sítios escolhidos ou apropriados, aumentando sua eficácia terapêutica e diminuindo seus efeitos colaterais. Uma estratégia criativa é utilizar nanopartículas multifuncionais, capazes de carregar o fármaco e que, adicionalmente, contenham um composto (proteína, anticorpo ou ligante) reconhecido apenas por proteínas ou receptores associados a células tumorais (biomarcadores). Dessa ...

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Multifunctional poly(d,l-lactide-co-glycolide)/montmorillonite (PLGA/MMT) nanoparticles decorated by Trastuzumab for targeted chemotherapy of breast cancer

Cited by 253 publications

References 47 publications

PLGA−POSS End-Linked Networks with Tailored Degradation and Shape Memory Behavior

PLGA−POSS End-Linked Networks with Tailored Degradation and Shape Memory Behavior

Recent Advances in the Generation of Antibody–Nanomaterial Conjugates

Hidróxidos duplos lamelares: nanopartículas inorgânicas para armazenamento e liberação de espécies de interesse biológico e terapêutico

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