Multifunctional polymer coatings for titanium implants

Szaraniec, B.; Pielichowska, Kinga; Pac, Ewelina; Menaszek, E.

doi:10.1016/j.msec.2018.08.065

Cited by 32 publications

(27 citation statements)

References 22 publications

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“…The cell behavior was also examined by a fluorescence microscope (Olympus, Japan) using a cell staining method. A total of 0.1% acridine orange (AO, sigma, Saint Louis, MO, USA) was utilized to visualize the remaining cells on the substrates [28], staining the cells for 1-2 min.…”

Section: Cell Cultivationmentioning

confidence: 99%

Investigation of the Oxidation Mechanism of Dopamine Functionalization in an AZ31 Magnesium Alloy for Biomedical Applications

et al. 2019

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Implant design and functionalization are under significant investigation for their ability to enhance bone-implant grafting and, thus, to provide mechanical stability for the device during the healing process. In this area, biomimetic functionalizing polymers like dopamine have been proven to be able to improve the biocompatibility of the material. In this work, the dip coating of dopamine on the surface of the magnesium alloy AZ31 is investigated to determine the effects of oxygen on the functionalization of the material. Two different conditions are applied during the dip coating process: (1) The absence of oxygen in the solution and (2) continuous oxygenation of the solution. Energy dispersive spectroscopy (EDS) and Fourier transform infrared spectroscopy (FTIR) are used to analyze the composition of the formed layers, and the deposition rate on the substrate is determined by molecular dynamic simulation. Electrochemical analysis and cell cultivation are performed to determine the corrosion resistance and cell’s behavior, respectively. The high oxygen concentration in the dopamine solution promotes a homogeneous and smooth coating with a drastic increase of the deposition rate. Also, the addition of oxygen into the dip coating process increases the corrosion resistance of the material.

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Section: Cell Cultivationmentioning

confidence: 99%

Investigation of the Oxidation Mechanism of Dopamine Functionalization in an AZ31 Magnesium Alloy for Biomedical Applications

et al. 2019

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“…In connection with the above disadvantages of titanium alloys and the increasing necessity for the quality of implant materials, there is a need for improving the tribological characteristics, as well as the degree of osseointegration of orthopedic products made from this material. One of the possible ways in which to solve the problems mentioned above is the formation on the surface of a titanium implant of a functional coating possessing a required set of characteristics [11][12][13][14][15][16]. Today, there are several ways to form biocompatible and/or bioactive coatings on implants by deposition of the hydroxyapatite or other calcium phosphates on their surface.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Coatings Formed on Titanium by Plasma Electrolytic Oxidation: Composition and Properties

et al. 2020

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Bioactive coatings on VT1-0 commercially pure titanium were formed by the plasma electrolytic oxidation (PEO). A study of the morphological features of coatings was carried out using scanning electron microscopy. A composition of formed coatings was investigated using energy-dispersive spectroscopy and X-ray diffractometry analysis. It was shown that PEO-coatings have calcium phosphate in their composition, which increases the bioactivity of the surface layer. Electrochemical properties of the samples were studied by potentiondynamic polarization and electrochemical impedance spectroscopy in different physiological media: simulated body fluid and minimum essential medium. The data of electrochemical studies indicate more than 15 times decrease in the corrosion current density for the sample with coating (5.0 × 10−9 A/cm2) as compared to the bare titanium (7.7 × 10−8 A/cm2). The formed PEO-layers have elastoplastic properties close to human bone (12–30 GPa) and a lower friction coefficient in comparison with bare metal. The wettability of PEO-layers increased. The contact angle for formed coatings reduced by more than 60° in comparison with bare metal (from 73° for titanium to 8° for PEO-coating). Such an increase in surface hydrophilicity contributes to the greater biocompatibility of the formed coating in comparison with commercially pure titanium. PEO can be prospective as a method for improving titanium surface bioactivity.

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“…Different coating strategies can be adopted, such as plasma assisted deposition [46], solvent evaporation [47], sol-gel dip coating [48], dip coating [49] and so forth. As a matter of fact, the application of polymeric protective coatings via electrochemical processes on titanium represents one of the most powerful strategies to obtain a superior adhesion of the polymer layer to the metal substrate with high resistance to mechanical wear.…”

Section: Bio-inert Systems: Anticorrosion and Barrier Filmsmentioning

confidence: 99%

Electrochemical Strategies for Titanium Implant Polymeric Coatings: The Why and How

et al. 2019

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Among the several strategies aimed at polymeric coatings deposition on titanium (Ti) and its alloys, metals commonly used in orthopaedic and orthodontic prosthesis, electrochemical approaches have gained growing interest, thanks to their high versatility. In this review, we will present two main electrochemical procedures to obtain stable, low cost and reliable polymeric coatings: electrochemical polymerization and electrophoretic deposition. Distinction should be made between bioinert films—having mainly the purpose of hindering corrosive processes of the underlying metal—and bioactive films—capable of improving biological compatibility, avoiding inflammation or implant-associated infection processes, and so forth. However, very often, these two objectives have been pursued and achieved contemporaneously. Indeed, the ideal coating is a system in which anti-corrosion, anti-infection and osseointegration can be obtained simultaneously. The ultimate goal of all these coatings is the better control of properties and processes occurring at the titanium interface, with a special emphasis on the cell-coating interactions. Finally, advantages and drawbacks of these electrochemical strategies have been highlighted in the concluding remarks.

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Multifunctional polymer coatings for titanium implants

Cited by 32 publications

References 22 publications

Investigation of the Oxidation Mechanism of Dopamine Functionalization in an AZ31 Magnesium Alloy for Biomedical Applications

Investigation of the Oxidation Mechanism of Dopamine Functionalization in an AZ31 Magnesium Alloy for Biomedical Applications

Bioactive Coatings Formed on Titanium by Plasma Electrolytic Oxidation: Composition and Properties

Electrochemical Strategies for Titanium Implant Polymeric Coatings: The Why and How

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