Multifunctional polysaccharide nanoprobes for biological imaging

Ju, Jingxuan; Xu, Danni; Mo, Xuan; Miao, Jianjun; Xu, Li; Ge, Guangbo; Zhu, Xun; Deng, Hongping

doi:10.1016/j.carbpol.2023.121048

Cited by 13 publications

(5 citation statements)

References 238 publications

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“…However, it is precisely the many limitations of a single technology that have prompted the combination of multiple technologies to overcome each other's shortcomings, forming multiple imaging technologies. [ 203,204 ]…”

Section: Multimodal Energy Transformation For Cancer Imaging‐guided T...mentioning

confidence: 99%

Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

Xu,

Kim,

Zhao

et al. 2024

Advanced Materials

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Cancer treatment requires precise tumor‐specific targeting at specific sites that allows for high‐resolution diagnostic imaging and long‐term patient‐tailorable cancer therapy while minimizing side effects largely arising from non‐targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue‐penetrative ultrasound, magnetic field, light, and radiation, that enable local activation for cancer imaging and therapy in deep tumors. A myriad of nanomedicines can be efficiently activated when the energy of such remote stimuli can be transformed into another type of energy. This review discusses the remote control of energy transformation for targetable, efficient, and long‐term cancer imaging and therapy. Such ultrasonic, magnetic, photonic, radiative, and radioactive energy can be transformed into mechanical, thermal, chemical, and radiative energy to enable a variety of cancer imaging and treatment modalities. The current review article describes multimodal energy transformation where a serial cascade or multiple types of energy transformation occur. This review includes not only mechanical, chemical, hyperthermia, and radiation therapy but also emerging thermoelectric, pyroelectric, and piezoelectric therapies for cancer treatment. It also illustrates ultrasound, magnetic resonance, fluorescence, computed tomography, photoluminescence, and photoacoustic imaging‐guided cancer therapies. It highlights afterglow imaging that can eliminate autofluorescence for sustained signal emission after the excitation.This article is protected by copyright. All rights reserved

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Section: Multimodal Energy Transformation For Cancer Imaging‐guided T...mentioning

confidence: 99%

Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

Xu,

Kim,

Zhao

et al. 2024

Advanced Materials

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“…They play essential roles in cellular and intracellular interactions thanks to their action as signaling molecules and their presence on cell surface receptors [3]. These functions explain the potential of carbohydrates for use as drug delivery [4][5][6], diagnostic, and theranostic agents [4,[7][8][9]. D-galactose (Gal), a monosaccharide sugar, has demonstrated its utility as a ligand in various applications.…”

Section: Introductionmentioning

confidence: 99%

Galactose: A Versatile Vector Unveiling the Potentials in Drug Delivery, Diagnostics, and Theranostics

Battisegola,

Billi,

Molaro

et al. 2024

Pharmaceuticals

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D-galactose, a simple natural compound, has been investigated as a powerful scaffold for drug delivery, diagnostics, and theranostics due to its distinctive properties and interactions with specific cell receptors. In the field of drug delivery, galactose functions as a ligand to selectively target cells expressing galactose receptors, such as hepatocytes, macrophages, and specific cancer cells. The direct attachment of galactose to the main drug or to drug-loaded nanoparticles or liposomes enhances cellular uptake, thereby improving drug delivery to the intended target cells. Galactose has also been found to be useful in diagnostics. Specifically, diagnostic tests based on galactose, such as the galactose elimination capacity test, are utilized to evaluate liver function and assess liver disease as well as hepatic functional reserve. Additionally, galactose-based theranostic agents can be designed by combining drug delivery and diagnostic capabilities. This review is an update of our previous review concerning the broad spectrum of possibilities for exploiting D-galactose as a vector for prodrug design and the synthetic strategies that allow its realization, jointly in diagnostics and theranostics, to highlight the versatility of this interesting vector.

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“…[28][29][30] The recent progress on the development of multifunctional nanoprobes for biological imaging from polysaccharides has been described in a very recent and interesting review. [31] Indeed, the combination of polysaccharides and CAs allows to construct macromolecules for imaging applications with improved biocompatibility, biodegradability, and solubility. In 2020 our group reported the synthesis of water-soluble supramolecular polynitroxides obtained from cyclodextrins (CDs) functionalized with TEMPO radicals.…”

Section: Introductionmentioning

confidence: 99%

Redox Properties and in Vivo Magnetic Resonance Imaging of Cyclodextrin‐Polynitroxides Contrast Agents

et al. 2023

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This paper reports the synthesis, characterization and in vivo application of water‐soluble supramolecular contrast agents (Mw: 5–5.6 kDa) for MRI obtained from β‐cyclodextrin functionalized with different kinds of nitroxide radicals, both with piperidine structure (CD2 and CD3) and with pyrrolidine structure (CD4 and CD5). As to the stability of the radicals in presence of ascorbic acid, CD4 and CD5 have low second order kinetic constants (≤0.05 M−1 s−1) compared to CD2 (3.5 M−1 s−1) and CD3 (0.73 M−1 s−1). Relaxivity (r1) measurements on compounds CD3‐CD5 were carried out at different magnetic field strength (0.7, 3, 7 and 9.4 T). At 0.7 T, r1 values comprised between 1.5 mM−1 s−1 and 1.9 mM−1 s−1 were found while a significant reduction was observed at higher fields (r1≈0.6‐0.9 mM−1 s−1 at 9.4 T). Tests in vitro on HEK293 human embryonic kidney cells, L929 mouse fibroblasts and U87 glioblastoma cells indicated that all compounds were non‐cytotoxic at concentrations below 1 μmol mL−1. MRI in vivo was carried out at 9.4 T on glioma‐bearing rats using the compounds CD3‐CD5. The experiments showed a good lowering of T1 relaxation in tumor with a retention of the contrast for at least 60 mins confirming improved stability also in vivo conditions.

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Multifunctional polysaccharide nanoprobes for biological imaging

Cited by 13 publications

References 238 publications

Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

Galactose: A Versatile Vector Unveiling the Potentials in Drug Delivery, Diagnostics, and Theranostics

Redox Properties and in Vivo Magnetic Resonance Imaging of Cyclodextrin‐Polynitroxides Contrast Agents

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