Multifunctional rotational active valve for flow control in paper-based microfluidic devices

Hussain, Gohar; Jafry, Ali Turab; Malik, Sohail; Shah, Syed Farhad; Nishat, Sumaira; Awan, Fazli Rabbi

doi:10.1016/j.snb.2022.133142

Cited by 13 publications

(4 citation statements)

References 32 publications

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“…For instance, food quality sensors such as time-temperature indicators need their timescale to be as linear as possible for better readout [7]. Moreover, flow control in paper microfluidics is required which can switch the fluid on and off during working [8].…”

Section: Methodsmentioning

confidence: 99%

Flow control in paper-based microfluidic channel by using hydrophobic tape barrier on the paper surface

et al. 2023

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Paper-based microfluidics offers a simple, cost-effective, and versatile platform for fluid manipulation and analysis. Despite significant advancements in paper fluidics, the flow control in paper channel remains a challenging task. In this regard, we have developed a flow delay channel in paper using rectangular tape patterns on the paper surface. We have investigated the effect of hydrophobic tape barriers with varying widths. The designing and cutting of the hydrophobic tape and paper channel was performed by CO2 laser machine using CorelDraw software. Once cut, the tape barriers were attached to the paper surface and then passed through the roller press machine for proper adhesion of tape pattern onto the paper’s surface. From experiments, we observed that by increasing the width of tape, the delay also increased. The hydrophobic tape on the paper surface caused resistance to the flowing fluid. Due to this surface resistance, flow velocity reduced, and the time delay increased. We believe that our novel approach will provide an alternative method of flow control for paper-based microfluidic devices and can be utilized in various food quality sensors and lateral flow devices.

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Section: Methodsmentioning

confidence: 99%

Flow control in paper-based microfluidic channel by using hydrophobic tape barrier on the paper surface

et al. 2023

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“…For instance, food quality sensors such as time-temperature indicators require flow control for better resolution [11]. Moreover, switching flow on and off in paper microfluidics is also an important aspect [12]. We found that no work has been done based on the effect of reservoir on the main paper channel.…”

Section: Introductionmentioning

confidence: 98%

Actuation and Flow Control in Paper-Based Microfluidics by Varying Thickness of Storage Reservoir

et al. 2023

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This paper discusses the potential of paper-based microfluidic devices for affordable diagnostics, and the importance of flow control. We have explored the variation of the width of paper, effect of 2D flow, and altering the surface wettability of paper to increase the resistance to fluid flow by physicochemical barriers. We used Whatman filter paper No. 40 and No. 1, mustard oil, and oleic acid, to examine the fluid flow due to capillary forces. Moreover, the effect of increase in thickness of the storage reservoir to decrease flow rate in the paper was also investigated. The experiments provide valuable insights into the behavior of fluid flow in porous media, and the findings have important applications in biomedical diagnostics and environmental monitoring.

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“…11 Paper-based microfluidic analytical devices (μPADs) have emerged as an ideal solution for field detection, owing to their notable adsorption capacity, portability, and cost-effectiveness. 12 The construction of hydrophilic channels and hydrophobic barriers on μPADs by printing hydrophobic materials facilitates the capillary action of paper-based fibers. 13,14 These detection materials are deposited on the test zone, allowing for long-term storage.…”

Section: ■ Introductionmentioning

confidence: 99%

“…While these traditional instruments offer high sensitivity and accuracy, their drawbacks, including intricate operation, labor-intensive sample pretreatment, and costly reagents, restrict their widespread use in field detection . Paper-based microfluidic analytical devices (μPADs) have emerged as an ideal solution for field detection, owing to their notable adsorption capacity, portability, and cost-effectiveness . The construction of hydrophilic channels and hydrophobic barriers on μPADs by printing hydrophobic materials facilitates the capillary action of paper-based fibers. , These detection materials are deposited on the test zone, allowing for long-term storage.…”

Section: Introductionmentioning

confidence: 99%

Paper-Based Microfluidic Sensors Utilizing Metal–Organic Framework Materials Modified with Europium and Carbon Quantum Dots for Anthrax Spore Biomarker Detection

Wang,

Mei,

et al. 2024

ACS Appl. Nano Mater.

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The germination of bacterial spores presents a considerable challenge to health and safety due to the current scarcity of cost-effective and efficient tools for their prompt identification. Addressing this critical need, our study introduces a novel paper-based ratiometric fluorescence sensor platform utilizing a composite of Eu 3+ -doped carbon quantum dots (CQDs) within ZIF-8 (Eu 3+ -CQDs@ZIF-8). This platform facilitates the rapid detection of 2, 6-pyridinedicarboxylic acid (DPA), a biomarker of bacterial spore germination. To fabricate this sensor, CQDs and Eu 3+ ions were synergistically integrated into the ZIF-8 framework. The resultant composite was then applied to filter paper via screen printing technology, creating a paper-based microfluidic analytical device (μPAD). During the process of detecting DPA, strong coordination between DPA and Eu 3+ ions is established, resulting in an enhanced red emission due to energy transfer through the antenna effect. Concurrently, the interaction between DPA and CQDs leads to a quenching of the CQDs' green fluorescence, enabling a ratiometric detection of DPA. The efficacy of this composite material was validated through the visualization of DPA release during spore germination. Further enhancing the platform's utility, integration with a smartphone enabled the quantification of DPA concentrations in real samples by analyzing the red-to-green (R/G) value in the detection area. Demonstrating rapid, sensitive, and precise DPA detection, the platform confirms its suitability for practical applications. Conclusively, with its compact design, straightforward preparation, and comprehensive integration, this sensor platform emerges as a promising solution for on-site spore detection, highlighting its potential for widespread testing applications.

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Multifunctional rotational active valve for flow control in paper-based microfluidic devices

Cited by 13 publications

References 32 publications

Flow control in paper-based microfluidic channel by using hydrophobic tape barrier on the paper surface

Flow control in paper-based microfluidic channel by using hydrophobic tape barrier on the paper surface

Actuation and Flow Control in Paper-Based Microfluidics by Varying Thickness of Storage Reservoir

Paper-Based Microfluidic Sensors Utilizing Metal–Organic Framework Materials Modified with Europium and Carbon Quantum Dots for Anthrax Spore Biomarker Detection

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