Multifunctional Silica Nanocapsule with a Single Surface Hole

Abstract

Multifunctional silica nanocapsules containing magnetic nanoparticles and fluorescent quantum dots with a single surface hole fabricated by a single‐step emulsion‐mediated process are described. The silica nanocapsules (see images) are easily internalized by phagocytic dendritic cells and show a high potential as bimodal imaging contrast agents (for fluorescence and magnetic resonance imaging) in vivo as well as in vitro.

Multifunctional Mesoporous Nanoellipsoids for Biological Bimodal Imaging and Magnetically Targeted Delivery of Anticancer Drugs

“…The darkened images from the injection site confi rm the imaging capability of MFNEs ( Figure 4b , area pointed by the arrow). [ 33 ] The darkened area extended over the tumor with time (from 0.5 h to 1.5 h), indicating the diffusion of MFNEs within the tumor. The results demonstrate that the obtained MFNEs could be employed as contrast agents for MRI during chemotherapy to follow the therapeutic effect by providing more imaging information for doctors.…”

A facile two-step etching method to fabricate porous hollow silica particles

“…The synthesis of nano-or micro-sized hollow silica particles has attracted widespread attention in recent years due to their unique properties and numerous applications in the fields of catalysis [1,2], separation [3][4][5], cell-labeling [6,7], ultrasound imaging [8], photonic crystals [9], and drug delivery [10][11][12][13][14][15][16][17][18][19]. Up to now, various synthetic techniques such as spray drying [14,20], interfacial polymerization [21,22], self-assembly [5,11], layer-by-layer (LBL) fabrication [23,24], and templating have been established for making hollow silica particles.…”

Luminescent magnetic particles: structures, syntheses, multimodal imaging, and analytical applications

“…Cells encapsulating the modified LuMaPs were imaged with MRI and luminescence imaging techniques. Lim et al [120] tracked dendritic cells, which are part of the mammalian immune system, in vivo using NIR fluorescence imaging after LuMaPs injection (Str. 35).…”

“…Magnetic core with multiple matrix shells, of which every second shell has embedded QDs [85] 29 Hollow polyelectrolyte capsule with MNPs and one dye in the shell and the other in the core [12] 30 Hollow stimuli responsive polymer capsule with mobile luminescent and magnetic core inside [115] 31 Hollow polyelectrolyte capsule with MNPs and QDs in both the hollow core and the shell [116] 32 Hollow magnetic core with multiple shells of polyelectrolytes and QDs [117] 33 Multiple compartment capsules from polyelectrolytes filled with MNPs and luminescent dyes [118] or nanocrystals 34 Core of MNPs and QDs coated with a cross-linked block-copolymer [119] 35 Hollow silica capsule with a single hole and embedded luminescent and magnetic nanocrystals [120] 36 Hollow capsule with MNPs in the matrix and a luminescent moiety attached to the surface [121] 37 Porous matrix capsules with both MNPs and dyes embedded in the matrix [25] 38 Hollow magnetic capsule coated with QDs [122] 39 Hollow polyelectrolyte capsule with MNPs in the core and QDs in the shell [123] 40 Emulsifier stabilized droplet incorporating magnetic and luminescent moieties [124, 125] 41 Droplet stabilized by emulsifier conjugates with gadolinium and luminescent dyes [126] 42 Droplet holding MNPs encapsulated in a polymer matrix. The luminescent component is embedded [127] in the matrix shell 43 Droplet containing MNPs stabilized by an emulsifier and emulsifier-dye conjugates [128] 44 Matrix with embedded luminophores coated with MNPs via a covalent linker [129] 45 Matrix with embedded luminophores coated with gadolinium via a covalent linker [130] 46 Matrix with embedded luminophores coated with gadolinium in a cross-linked shell [130] 47 Silica-coated QD modified with a PEG emulsifier and lipid-gadolinium conjugates [131] Schematic representations of each structure can be seen in Fig.…”