Multifunctional Smart Skin Adhesive Patches for Advanced Health Care

Hwang, Il Soon; Kim, Hong Nam; Seong, Minho; Lee, Sang-Hyeon; Kang, Minsu; Yi, Hoon; Bae, Won‐Gyu; Kwak, Moon Kyu; Jeong, Hoon Eui

doi:10.1002/adhm.201800275

Cited by 158 publications

(131 citation statements)

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“…Detachment on moist wound areas may also cause skin damage and contamination. In addition, irritation or allergic responses (e.g., redness, itching, or festering) may be induced by chemical species or low air/water permeability for wet or damaged skin . Nanoparticle adhesives have reported firm tissue attachment, but their chemical bonding are known to weaken upon exposure to water .…”

Section: Outer/inner Organ Adhesive Patches Based On Bioinspired Archmentioning

confidence: 99%

“…Specifically, the mucus with interpenetrating positively charged chemistries produce pedal waves; this in all creates an adhesive and elastic dissipative matrix, and guides the movement of slugs on attached surfaces . Hence, structural features within the as‐mentioned organisms have built the platform of bioinspired adhesive systems for potential use in clean transfer systems, soft robotics, stimuli‐responsive adhesives for dry or wet surfaces, and various wearable devices with diagnostic and therapeutic functionalities …”

Section: Introductionmentioning

confidence: 99%

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Bioinspired Adhesive Architectures: From Skin Patch to Integrated Bioelectronics

et al. 2019

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on dry and rough surfaces (maximum ≈10 N cm −2 ). [1] Close observations have indicated nanoscale hairs of high aspect ratio (AR) with slated tips. [21][22][23][24][25][26][27][28][29][30] This geometry allows directional appliance of van der Waals forces against engaged surfaces for stable attachment. The attachment strategies and fixation systems of beetles have also been investigated. [9] Concave, mushroom-shaped architectures on the forelegs of beetles ensure stable adherences onto rough, waxy surfaces [31][32][33][34][35][36] or locomotion via capillary adhesion. [37][38][39] Studies on their attachment systems revealed that the mushroom-shaped structures with wide concave tips can generate van der Waals interactions [40] as well as a suction effect against engaged surfaces. [41,42] Moreover, needles located in the proboscis of mosquitos [43][44][45][46] or endoparasites (e.g., Pomphorhynchus laevis) [47] alike, induce mechanical interlocking on dry skin or wet organs. The needles provide strong adhesion in both normal and shear directions for the insect species to easily consume nutrients. Recently, the architectures of octopus suckers were investigated to understand their underlying attachment mechanism. Existing in clusters on octopus tentacles, suction cups are crucial for octopi's survival underwater for functions such as preying, grasping, locomotion, and even sensing. The cup-shaped protruding chamber (infundibulum) is known to adapt and seal conformably on rough surfaces. [12,13,15,48] Meanwhile, the dome-like protuberance in the lower chamber (acetabulum) forms pressure difference between the segregated lower and upper chambers within the suction cup architecture. [49] This enhances suction stress to adhere strongly onto wet or underwater surfaces. The footpads of slugs are covered with structures of microscale compression waves with viscous mucus. This can be used to both lubricate a slug's movement over surfaces and facilitate the transfer of adhesive force to the engaged surfaces. [16,19,20,[50][51][52] Specifically, the mucus with interpenetrating positively charged chemistries produce pedal waves; this in all creates an adhesive and elastic dissipative matrix, and guides the movement of slugs on attached surfaces. [53] Hence, structural features within the as-mentioned organisms have built the platform of bioinspired adhesive systems for potential use in clean transfer systems, [54][55][56][57][58][59] soft robotics, [60,61] stimuli-responsive adhesives for dry or wet surfaces, [62][63][64] and various wearable devices with diagnostic and therapeutic functionalities. [65][66][67][68][69] Among various applications of bioinspired multiscale architectures, patches attachable to skin have been of high interest (Figure 1b). Human skin, the outermost organ of the human The attachment phenomena of various hierarchical architectures found in nature have extensively drawn attention for developing highly biocompatible adhesive on skin or wet inner organs without any chemical glue. Structural adhesive sy...

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Section: Outer/inner Organ Adhesive Patches Based On Bioinspired Archmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioinspired Adhesive Architectures: From Skin Patch to Integrated Bioelectronics

et al. 2019

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“…Micropillar‐based e‐skins showed higher sensitivity over pressure and shear compared to planar e‐skins. Whereas the microscale pyramids and pillars were harnessed to increase sensitivity to normal and shear stresses, microwrinkle‐based e‐skin could improve sensitivity for normal and tensile stresses, as the regularly buckled geometry of the microwrinkles enables increased stretchability, similar to hierarchical wrinkles and folds in human skin . These results demonstrate that the sensing capability of various e‐skins can be enhanced by integrating functional nanomaterials with proper microscopic architectures .…”

Section: Introductionmentioning

confidence: 84%

Hybrid Architectures of Heterogeneous Carbon Nanotube Composite Microstructures Enable Multiaxial Strain Perception with High Sensitivity and Ultrabroad Sensing Range

Sun

Park

et al. 2018

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/smll.201803411.Low-dimensional nanomaterials are widely adopted as active sensing elements for electronic skins. When the nanomaterials are integrated with microscale architectures, the performance of the electronic skin is significantly altered. Here, it is shown that a high-performance flexible and stretchable electronic skin can be produced by incorporating a piezoresistive carbon nanotube composite into a hierarchical topography of micropillar-wrinkle hybrid architectures that mimic wrinkles and folds in human skin. Owing to the unique hierarchical topography of the hybrid architectures, the hybrid electronic skin exhibits versatile and superior sensing performance, which includes multiaxial force detection (normal, bending, and tensile stresses), remarkable sensitivity (20.9 kPa −1 , 17.7 mm −1 , and gauge factor of 707 each for normal, bending, and tensile stresses), ultrabroad sensing range (normal stress = 0-270 kPa, bending radius of curvature = 1-6.5 mm, and tensile strain = 0-50%), sensing tunability, fast response time (24 ms), and high durability (>10 000 cycles). Measurements of spatial distributions of diverse mechanical stimuli are also demonstrated with the multipixel electronic skin. The stress-strain behavior of the hybrid structure is investigated by finite element analysis to elucidate the underlying principle of the superior sensing performance of the electronic skin. Electronic Skins www.advancedsciencenews.com

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“…Various wearable sensors, including flexible sensors and wearable electronics, have been developed by incorporation of functional nanomaterials into flexible supporting materials . Excellent sensors call for accurate and sensitive detection of related indicators; however, poor adhesion to human skin fails to provide stable sensing, the close contact and adhesion to human skin is of great importance for precise and long‐term stable human health monitoring . In addition, commercially available wearable sensors are mainly focused on tracking personal physical activities (heart rate and step number), and they usually ignore the sensing of physiological indicators.…”

mentioning

confidence: 99%

“…Despite the remarkable advances in wearable devices, the combination of microfluidic and electronic systems to achieve highly integrated systems remains a great challenge. As one of the body fluids, human sweat is of great importance, sweat contains various health information, sweat can be collected conveniently and noninvasively, which make it potential in personal analysis . I recently there witnessed an explosive of progress made in developing biosensors for sweat sensing …”

mentioning

confidence: 99%