Multifunctional system for observing, measuring and analyzing stimulation-evoked neurochemical signaling

Abstract

The ability to measure neurotransmitter activity using implanted electrochemical sensors offers researchers a potent technique for analyzing neural activity across specific neural circuitry. We have developed a wirelessly controlled device, WINCS Harmoni, to observe and measure neurotransmitter dynamics at up to four separate sensors, with high temporal and spatial resolution. WINCS Harmoni also incorporates a versatile neurostimulator that can be synchronized with electrochemical recording. The WINCS Harmoni platform is thus optimally suited for probing the neurochemical effects of neurostimulation, and may in turn enable the development of personalized therapies for multiple brain disorders.

Advances in neurochemical measurements: A review of biomarkers and devices for the development of closed-loop deep brain stimulation systems

“…In 2013, the Mayo Investigational Neurostimulator Control System (MINCS) was released, introducing an independent stimulating channel to the WINCS platform, thereby enabling simultaneous neurostimulation and neurochemical recording [ 83 ]. In 2017, the Mayo Clinic released the synchronized neuromodulatory and sensing platform WINCS Harmoni – a wireless, multichannel stimulating and sensing system for in-vivo neurochemical recordings across multiple anatomical targets [ 84 , 85 ]. WINCS Harmoni is also capable of applying either fixed potential amperometry or FSCV, therefore providing further flexibility in terms of experimental approach.…”

“…WINCS Harmoni is paired with the software platform WincsWare for wireless control and telemetry, enabling real-time data analysis and individualized stimulation parameter development [ 85 ]. WincsWare allows full control of the stimulation and sensing systems, featuring configurable parameter settings including pyramidal, N-Wave, and custom-designed FSCV scans with adjustable paired-pulse voltammetry [ 86 ] settings as well as fixed potential amperometry.…”