Multifunctional TRPV1 Ion Channels in Physiology and Pathology with Focus on the Brain, Vasculature, and Some Visceral Systems

Storozhuk, Maksim; Moroz, Olesia F; Zholos, Alexander

doi:10.1155/2019/5806321

Cited by 65 publications

(44 citation statements)

References 123 publications

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“…The cooling effect can be explained as a cold hyperalgesia caused by activating TRPM8 channels and suppressing compound action potentials (CAP), raising the temperature threshold to feel coldness, i.e., making the sensation of coldness occur at a higher temperature. TRPV1 is one of the temperature-sensitive channels specific for heat stimuli (>43 • C) and extracellular pH, and it also has a crucial role in pathological forms of pain [191,192]. Activation of TRPV1 induces pain hypersensitivity (thermal hyperalgesia).…”

Section: The Receptors and Neuromodulatorsmentioning

confidence: 99%

“…Activation of the GABA B receptor was found to inhibit TRPV1 sensitization, and TRPV1 activation triggers GABA release [191]. Importantly, this inhibition of TRPV1 through activation of GABA B receptors selectively suppresses the sensitized status of TRPV1 and does not affect acute TRPV1 pain signaling [191,192]. There are many plants (for example green tea (Camellia sineusis) and soybean (Glycine max)), which include GABA [194][195][196] and there are many chemical compounds in plants, which modulate the action of GABA on GABA receptors.…”

Section: The Receptors and Neuromodulatorsmentioning

confidence: 99%

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The Effects of Essential Oils and Terpenes in Relation to Their Routes of Intake and Application

Koyama

Heinbockel

2020

IJMS

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Essential oils have been used in multiple ways, i.e., inhaling, topically applying on the skin, and drinking. Thus, there are three major routes of intake or application involved: the olfactory system, the skin, and the gastro-intestinal system. Understanding these routes is important for clarifying the mechanisms of action of essential oils. Here we summarize the three systems involved, and the effects of essential oils and their constituents at the cellular and systems level. Many factors affect the rate of uptake of each chemical constituent included in essential oils. It is important to determine how much of each constituent is included in an essential oil and to use single chemical compounds to precisely test their effects. Studies have shown synergistic influences of the constituents, which affect the mechanisms of action of the essential oil constituents. For the skin and digestive system, the chemical components of essential oils can directly activate gamma aminobutyric acid (GABA) receptors and transient receptor potential channels (TRP) channels, whereas in the olfactory system, chemical components activate olfactory receptors. Here, GABA receptors and TRP channels could play a role, mostly when the signals are transferred to the olfactory bulb and the brain.

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Section: The Receptors and Neuromodulatorsmentioning

confidence: 99%

Section: The Receptors and Neuromodulatorsmentioning

confidence: 99%

The Effects of Essential Oils and Terpenes in Relation to Their Routes of Intake and Application

Koyama

Heinbockel

2020

IJMS

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“…Second, the post-administration duration required to produce the antitussive effect is shorter through inhalation than that via IP injection (5 min vs. 40 min). Third, owing to the presence of TRPV1 and EP3 receptor in a variety of organs, such as the brains (for a review, see [51,52]), inhalation of these antagonists should have less possible side effects as compared to systemic administration. In summary, our results not only reveal the higher antitussive e cacy of these antagonists via inhalation than systemic administration, but also support the interaction of TRPV1 and EP3 receptor in cough mainly occurring in airway sensory bers.…”

Section: Discussionmentioning

confidence: 99%

Interaction of TRPV1 and EP3 Receptor in Cough and Bronchopulmonary C-Neural Activities

Gao¹,

Zhuang²,

Zhao³

et al. 2020

Preprint

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Prostaglandin E2 (PGE2)-induced coughs in vivo and vagal nerve depolarization in vitro are inhibited by systemic and local administration of TRPV1 (JNJ 17203212) and prostaglandin EP3 receptor antagonists (L-798106) respectively. These results indicate an interaction of TRPV1 and EP3 receptor in cough responses to PGE2 likely through the vagal sensory nerve. This study aimed to determine whether 1) inhalation of aerosolized JNJ 17203212 and L-798106 affected cough responses to citric acid (CA to mainly stimulate TRPV1) and PGE2; 2) TRPV1 and EP3 receptor morphologically co-expressed and electrophysiologically functioned in the individual of vagal pulmonary C-neurons (cell bodies of bronchopulmonary C-fibers in the nodose/jugular ganglia); and 3) the interaction of the two receptors occurred in these neurons. To this end, aerosolized CA or PGE2 was inhaled by unanesthetized guinea pigs pretreated without or with JNJ 17203212 or L-798106 given in aerosol. Immunofluorescence was applied to identify the expression of the two receptors in vagal pulmonary C-neurons (retrogradely traced by DiI). Whole-cell patch clamp approach was used to detect capsaicin (CAP)- and PGE2-induced currents in the same neurons and determine the effects of the TRPV1 and EP3 receptor antagonists on the currents. We found that PGE2-evoked cough was attenuated by JNJ 17203212 or L-798106 and CA-evoked cough greatly suppressed only by JNJ 17203212. EP3-labeled neurons always co-expressed TRPV1 with a cell size < 20 µm and occupied 1/4 of vagal pulmonary C-neurons. Both CAP- and PGE2-induced currents could be recorded in the individuals of some vagal pulmonary C-neurons. The former was largely inhibited only by JNJ 17203212, while the latter was suppressed by JNJ 17203212 or L-798106. The similarity of the interaction in cough and vagal pulmonary C-neural activity suggests that a subgroup of vagal pulmonary C-neurons co-expressing TRPV1 and EP3 receptor is, at least in part, responsible for the interaction of the two receptors in the cough response to PGE2.

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“…TRPV1 expression occurs in epidermis [60], polymorphonuclear granulocytes [61], smooth muscles [62], mast cells [63], dendritic cells, and macrophages [64]. Several studies have shown its expression in neuronal tissues brain regions [65,66], and in non-neuronal tissues Similarly, it is sensitized in the presence of inflammatory mediators such as prostaglandins and bradykinins, physical and chemical stimuli [67][68][69]. Capsaicin and other related compounds are lipophilic and share structural similarity with endogenous fatty acid derivatives that have been identified as TRPV1 agonists such as anandamide (an endocannabinoid) interact at intracellular regions of TRPV1 [70].…”

Section: Vasorelaxation Induced By Eugenol Involves Trpv1 Channel Actmentioning

confidence: 99%

Eugenol induces potent vasorelaxation in uterine arteries from pregnant goats – A promising natural therapeutic agent for hypertensive disorders of pregnancy

Parija

Jandhyam

Mohanty

et al. 2020

Preprint

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Please find attached our manuscript entitled “ Eugenol induces potent vasorelaxation in uterine arteries from pregnant goats – a promising natural therapeutic agent for hypertensive disorders of pregnancy ” Abstract Hypertensive disorders of pregnancy, including preeclampsia, affect about 8-13% of pregnancies and are the leading causes of pregnancy related maternal mortality worldwide. Poorly controlled high blood pressure during pregnancy increases the risk of pregnancy complications and development of future cardiovascular diseases. However, the choice for antihypertensive therapy during pregnancy has been limited due to side effects of many commonly used antihypertensive drugs and lack of other proven safe treatment options. Eugenol is a natural phenolic compound and the main component of clove oil. It is known for its antioxidant, anti-inflammatory and vasorelaxant actions. These beneficial effects of eugenol make it as an excellent therapeutic candidate for treatment of hypertensive disorders of pregnancy. Thus, as a first step, we compared the vasorelaxant effect of eugenol on the middle uterine arterial (MUA) rings from pregnant and nonpregnant goats. Additionally, we examined the potential involvement of the transient receptor potential channel 1 (TRPV1) in mediating the actions of eugenol and compared the effects with a known TRPV1 channel agonist, capsaicin. Isometric tension was measured in MUA rings from endometrial-myometrial junctions of pregnant and nonpregnant goats precontracted with phenylephrine, using a highly sensitive isometric force transducer and an automatic organ bath. The concentration-dependent contractile response curves of eugenol were compared to capsaicin, with and without pre-incubation of the MUA rings with a selective and non-selective TRPV1 antagonists, capsazepine (CAPZ) and Ruthenium Red (RR), respectively. Capsaicin induced concentration-dependent vasorelaxation in nonpregnant PE precontracted MUA rings and the concentration-response curve shifted to the right with significantly reduced pIC 50 and R max values in the presence of CAPZ and RR. The effects were similar in MUA rings from pregnant animals, except that there was a moderate increase in pIC 50 values in the presence of RR. Similarly, eugenol induced concentration-dependent vasorelaxation in both nonpregnant and pregnant PE precontracted MUA rings and the effects were markedly antagonized by CAPZ and RR. However, compared to capsaicin, the R max of eugenol was increased 31.25% in nonpregnant and 97.99% in pregnant MUA rings. These results suggest that eugenol has highly potent vasorelaxant effect in MUAs and its effect is partly mediated through activation of the TRPV1 channel. Most importantly, its vasorelaxant effect is about three-fold augmented in pregnancy, suggesting its potential value as a nutraceutical agent and therapeutic candidate for treatment of hypertensive disorders of pregnancy.

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Multifunctional TRPV1 Ion Channels in Physiology and Pathology with Focus on the Brain, Vasculature, and Some Visceral Systems

Cited by 65 publications

References 123 publications

The Effects of Essential Oils and Terpenes in Relation to Their Routes of Intake and Application

The Effects of Essential Oils and Terpenes in Relation to Their Routes of Intake and Application

Interaction of TRPV1 and EP3 Receptor in Cough and Bronchopulmonary C-Neural Activities

Eugenol induces potent vasorelaxation in uterine arteries from pregnant goats – A promising natural therapeutic agent for hypertensive disorders of pregnancy

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