Multifunctional Up‐Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual‐Responsive Drug Controlled Release

Zhang, Xiao; Yang, Piaoping; Dai, Yunlu; Ma, Ping’an; Li, Xuejiao; Cheng, Ziyong; Hou, Zhiyao; Kang, Xiaojiao; Li, Chunxia; Lin, Jun

doi:10.1002/adfm.201300136

Cited by 217 publications

(135 citation statements)

References 87 publications

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“…1,[4][5][6] The important advantages of polymer brushes are the mechanical stability, due to the covalent bonding to the substrate, and the high swelling ratio, which causes a significant thickness change upon switching between swollen and collapsed state in good and bad solvents, respectively. This makes them particularly interesting for controlled release, 7 tunable assembly of coated nanoparticles, 8 responsive nanoactuators 9,10 or for antifouling surfaces. 11,12 More recently, complex systems produced by embedding surfactants, 13,14 gels 15,16 or nanoparticles [17][18][19][20] into polymer brushes have been studied, from which multiresponsive coatings with enlarged applicability as stimuli-responsive systems can be designed.…”

Section: Introductionmentioning

confidence: 99%

Temperature responsive behavior of polymer brush/polyelectrolyte multilayer composites

et al. 2016

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aThe complex interaction of polyelectrolyte multilayers (PEMs) physisorbed onto end-grafted polymer brushes with focus on the temperature-responsive behavior of the system is addressed in this work. The investigated brush/multilayer composite consists of a poly(styrene sulfonate)/poly(diallyldimethylammonium chloride) (PSS/PDADMAC) multilayer deposited onto the poly(N-isopropylacrylamide-bdimethylaminoethyl methacrylate) P(NIPAM-b-DMAEMA) brush. Ellipsometry and neutron reflectometry were used to monitor the brush collapse with the thickness decrease as a function of temperature and the change in the monomer distribution perpendicular to the substrate at temperatures below, across and above the phase transition, respectively. It was found that the adsorption of PEMs onto polymer brushes had a hydrophobization effect on PDMAEMA, inducing the shift of its phase transition to lower temperatures, but without suppressing its temperature-responsiveness. Moreover, the diffusion of the free polyelectrolyte chains inside the charged brush was proved by comparing the neutron scattering length density profile of pure and the corresponding PEM-capped brushes, eased by the enhanced contrast between hydrogenated brushes and deuterated PSS chains. The results presented herein demonstrate the possibility of combining a temperature-responsive brush with polyelectrolyte multilayers without quenching the responsive behavior, even though significant interpolyelectrolyte interactions are present. This is of importance for the design of multicompartment coatings, where the brush can be used as a reservoir for the controlled release of substances and the multilayer on the top as a membrane to control the diffusion in/out by applying different stimuli.

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Section: Introductionmentioning

confidence: 99%

Temperature responsive behavior of polymer brush/polyelectrolyte multilayer composites

et al. 2016

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“…In addition, rough surfaces were present due to the different electron penetrability of the FHMSN cores and polymer (HA) shells, demonstrating the successful conjugation of HA. 32 The average diameter of the GNCs was 3.3 nm, which was optimal for capping the 3-nm-wide pores and preventing leakage of the entrapped Dox. The loading amount of the GNCs on the FHMSNs-P1 was optimized to 314 μg mg − 1 by monitoring the fluorescence spectra of the GNCs in the supernatant and in the stock solutions.…”

Section: Resultsmentioning

confidence: 99%

Peptide-mediated core/satellite/shell multifunctional nanovehicles for precise imaging of cathepsin B activity and dual-enzyme controlled drug release

Zheng

Zhang

et al. 2017

NPG Asia Mater

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Intracellular imaging of pathologically relevant proteases can provide essential information for the accurate evaluation of disease stage and progression. However, the risks of degradation by nonspecific enzymes during transportation and poor cellular uptake limit the use of peptide-based molecular probes (PMPs) for in situ protease imaging. To overcome these obstacles, a self-protected nanovehicle with a peptide-mediated core/satellite/shell structure was constructed for precise imaging of the protease cathepsin B (Cat B) in situ and the subsequent Cat B-responsive drug release. The self-protected nanovehicles demonstrated excellent resistance to nonspecific enzymolysis, thereby keeping the embedded PMPs intact until they reach the target organelle. Furthermore, the targeting ability of the outer shell facilitated the internalization of nanovehicles into tumor cells via receptor-guided recognition: the protective shell thereafter degraded in the intracellular microenvironment, and Cat B activity was dynamically monitored as the core/satellite structure disassembled. Meanwhile, the peptide-mediated satellite/shell structures served as three-dimensional gatekeepers to lock doxorubicin inside the nanovehicles, and drug release was spatiotemporally controlled by Cat B activity. This study provides important guiding principles for the rational design of self-protected nanovehicles for accurate diagnosis and therapy.

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“…These results are beneficial for the application of FA-RIPNPs in tumor therapy and imaging. [43][44][45] The excellent optical properties, including NIR fluorescence and absorbance, render ICG a good candidate for use as an imaging probe in clinical diagnosis. However, numerous disadvantages, including poor solubility in aqueous media and low photostability, generally limit biomedical applications.…”

Section: Plga-lipid Nanoparticles For Simultaneous Drug Delivery and mentioning

confidence: 99%

Development of PLGA-lipid nanoparticles with covalently conjugated indocyanine green as a versatile nanoplatform for tumor-targeted imaging and drug delivery

Xin

Yang

2016

IJN

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Multifunctional Up‐Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual‐Responsive Drug Controlled Release

Cited by 217 publications

References 87 publications

Temperature responsive behavior of polymer brush/polyelectrolyte multilayer composites

Temperature responsive behavior of polymer brush/polyelectrolyte multilayer composites

Peptide-mediated core/satellite/shell multifunctional nanovehicles for precise imaging of cathepsin B activity and dual-enzyme controlled drug release

Development of PLGA-lipid nanoparticles with covalently conjugated indocyanine green as a versatile nanoplatform for tumor-targeted imaging and drug delivery

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