Multifunctional ZnO/TiO2 nanoarray composite coating with antibacterial activity, cytocompatibility and piezoelectricity

Pang, Shumin; He, Yuan; Zhong, Ru Gang; Guo, Zhenzhao; He, Ping; Zhou, Changren; Xue, Bo; Wen, Xuejun; Li, Hong

doi:10.1016/j.ceramint.2019.03.076

Cited by 65 publications

(29 citation statements)

References 40 publications

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“…Likewise, under the action of an external electric field, piezoelectric materials can produce a geometric deformation proportional to the external electric field, which is termed the converse piezoelectric effect. Representative piezoelectric materials include nonferroelectric materials such as quartz and zinc oxide (ZnO), [ 5 ] and ferroelectric materials such as barium titanate (BaTiO 3 ), [ 6 ] lead zirconate titanate (Pb[Zr x Ti 1− x ]O 3 , PZT), [ 7 ] lithium niobate (LiNbO 3 ), [ 8 ] potassium sodium niobate (K 0.5 Na 0.5 NbO 3 , KNN), [ 9 ] polyvinylidene fluoride (PVDF) and its copolymers. [ 10 ] Interestingly, some animal tissues, such as collagen [ 11 ] and hydroxyapatite, [ 12 ] have also been found to be piezoelectric, which is a result of the asymmetrical structure of biological molecules, such as amino acids, that leads to the formation of a dipole.…”

Section: Introductionmentioning

confidence: 99%

Construction of Bio‐Piezoelectric Platforms: From Structures and Synthesis to Applications

et al. 2021

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Piezoelectric materials, with their unique ability for mechanical‐electrical energy conversion, have been widely applied in important fields such as sensing, energy harvesting, wastewater treatment, and catalysis. In recent years, advances in material synthesis and engineering have provided new opportunities for the development of bio‐piezoelectric materials with excellent biocompatibility and piezoelectric performance. Bio‐piezoelectric materials have attracted interdisciplinary research interest due to recent insights on the impact of piezoelectricity on biological systems and their versatile biomedical applications. This review therefore introduces the development of bio‐piezoelectric platforms from a broad perspective and highlights their design and engineering strategies. State‐of‐the‐art biomedical applications in both biosensing and disease treatment will be systematically outlined. The relationships between the properties, structure, and biomedical performance of the bio‐piezoelectric materials are examined to provide a deep understanding of the working mechanisms in a physiological environment. Finally, the development trends and challenges are discussed, with the aim to provide new insights for the design and construction of future bio‐piezoelectric materials.

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Section: Introductionmentioning

confidence: 99%

Construction of Bio‐Piezoelectric Platforms: From Structures and Synthesis to Applications

et al. 2021

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“…The nZnO/TiO 2 coated on the Ti substrate was synthesized by hydrothermal followed by a low-temperature liquid phase method with different temperate (50, 70, and 90 °C) [ 69 ]. From SEM analysis the shape of the composites was obtained to be rhombic prismatic and aligned in nanoarray.…”

Section: Introductionmentioning

confidence: 99%

“… Zn Others SEM/TEM/HRTEM/SAED Co-precipitation E. coli, B. subtilis, S. aureus, S. typhi. – FeSO 4 .7H 2 O and (NiNO 3 ) 2 .6H 2 O) Crystalline 0.25 [110] α-Fe 2 O 3 and 0.207 [200] NiO 25 on E. coli [ 66 ] Green and combustion E. coli NCIM-5022 and S. aureus NCIM-505 Zn(NO 3 ) 2 .6H 2 O Cu(NO 3 ) 2 .3H 2 O Calotropis gigantea 10–40-nm-sized spherical and hexagonal irregular shapes 9 on E. coli [ 67 ] Hydrothermal bottom-up approaches E. coli DH5 α Zn(AC) 2 .2H 2 O Tris(dimethylamino)silane 71.7-nm-sized ZnO/SiO2 nanowires – [ 68 ] Hydrothermal and low temperature liquid phase S. aureus (ATCC 25923) and E. coli (ATCC 25922) Zn(NO 3 ) 2 .6H 2 O Tetrabutyl titanate and Ti (TA 2 , China) 50–90-nm-sized nanoarray aligned rhombic prismatic shape – [ 69 ] Sol−gel B. subtilis, S. aureus S. mutans, E. coli, K. oxytoca, P. aeruginosa [Zn(NO 3 ) 2 Zr(C 4 H 9 O) 4 Cluster of amorphous particles ~ 7 on B. subtilis [ 70 ] Sol-gel E. coli ATCC 8739 , S. paratyphi ATCC 9150, S. aureus ATCC 33862 , and L. monocytogenes ATCC 15313 Zn(NO 3 ) 2 .6H 2 O Titanium-(IV) butoxide, and magnesium di-tert-butoxide ~ 100-nm-sized semi globular-ovoid shape 18 on S. paratyphi [ 71 ] Green E. coli, Klebsiella Zn(NO 3 ...…”

Section: Introductionmentioning

confidence: 99%

A Review on Enhancing the Antibacterial Activity of ZnO: Mechanisms and Microscopic Investigation

et al. 2020

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Metal oxide nanomaterials are one of the preferences as antibacterial active materials. Due to its distinctive electronic configuration and suitable properties, ZnO is one of the novel antibacterial active materials. Nowadays, researchers are making a serious effort to improve the antibacterial activities of ZnO by forming a composite with the same/different bandgap semiconductor materials and doping of ions. Applying capping agents such as polymers and plant extract that control the morphology and size of the nanomaterials and optimizing different conditions also enhance the antibacterial activity. Forming a nanocomposite and doping reduces the electron/hole recombination, increases the surface area to volume ratio, and also improves the stability towards dissolution and corrosion. The release of antimicrobial ions, electrostatic interaction, reactive oxygen species (ROS) generations are the crucial antibacterial activity mechanism. This review also presents a detailed discussion of the antibacterial activity improvement of ZnO by forming a composite, doping, and optimizing different conditions. The morphological analysis using scanning electron microscopy, field emission-scanning electron microscopy, field-emission transmission electron microscopy, fluorescence microscopy, and confocal microscopy can confirm the antibacterial activity and also supports for developing a satisfactory mechanism. Graphical abstract Graphical abstract showing the metal oxides antibacterial mechanism and the fluorescence and scanning electron microscopic images.

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“…In addition to improved bioactivity, positively polarized surfaces of HAp/BT composites showed antibacterial activity as well (Swain, Padhy, & Rautray, 2020). In another study, ZnO/TiO 2 coatings on metallic implant demonstrated better osteoblast cell proliferation with antibacterial property than bare metallic implants (Pang et al., 2019). Bioinspired 3D structures of BT showed significant enhancement in osteogenic differentiation in vitro (Marino et al., 2015).…”

Section: In Situ Electrical Stimulationmentioning

confidence: 98%

In situ electrical stimulation for enhanced bone growth: A mini‐review

2020

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The role of electrical stimuli in directing cellular activities during natural tissue healing and regeneration process has been well recognized. This observation has prompted the development and use of exogenous electrical stimulations in the treatment of delayed unions and non‐unions of bone fracture in different parts of the human skeletal system. Considerable amount of clinical evidences has also been generated on the benefits of exogenous bone growth stimulators. However, the clinical efficacy and safety of these exogenous electrical stimulating methods are being argued to be inconsistent and inconclusive, due to lack of sufficient number of well‐controlled, randomized clinical studies. As a result, there has been significant interest in the development of smart biomaterials, which can generate in situ electrical stimuli, for accelerated bone repair, healing and regeneration. These smart biomaterials are essentially either composite biomaterials containing electrically active materials or biomaterials that can be polarized. The primary objective of this mini review was to provide an overview of different exogenous electrical stimulation methods and biocomposites for in situ stimulation, which can be used for bone growth and healing. The first part is focused on exogenous stimulation methods, and the second part discusses the use of biocomposites containing electrically active materials such as piezoelectric materials and multiferroic materials for accelerated repair and regeneration of bone.

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Multifunctional ZnO/TiO2 nanoarray composite coating with antibacterial activity, cytocompatibility and piezoelectricity

Cited by 65 publications

References 40 publications

Construction of Bio‐Piezoelectric Platforms: From Structures and Synthesis to Applications

Construction of Bio‐Piezoelectric Platforms: From Structures and Synthesis to Applications

A Review on Enhancing the Antibacterial Activity of ZnO: Mechanisms and Microscopic Investigation

In situ electrical stimulation for enhanced bone growth: A mini‐review

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