2022
DOI: 10.1021/acsabm.2c00773
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Multifunctional β-Cyclodextrin–Poly(ethylene glycol)–Cholesterol Nanomicelle for Anticancer Drug Delivery

Abstract: Nanoparticle drug delivery systems have drawn considerable attention worldwide due to their unique characteristics and advantages in anticancer drug delivery. Herein, the curcumin (Cur) loaded nanomicelles with two-stage drug release behavior were developed. β-Cyclodextrin (β-CD) and cholesterol were conjugated onto both ends of the poly(ethylene glycol) (PEG) chain to obtain an amphiphilic β-CD-PEG-Chol. The Cur was loaded into the cavities of β-CD and nanomicelle when the β-CD-PEG-Chol self-assembled to the … Show more

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Cited by 4 publications
(3 citation statements)
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“…5 However, current collagen-based GBR membranes are limited by relatively simple composition, rapid degradation rate, insufficient biological activity, and poor osteogenic potential. 6 To overcome these hurdles, there is a great deal of potential for the advancement of GBR membranes.…”
Section: Introductionmentioning
confidence: 99%
“…5 However, current collagen-based GBR membranes are limited by relatively simple composition, rapid degradation rate, insufficient biological activity, and poor osteogenic potential. 6 To overcome these hurdles, there is a great deal of potential for the advancement of GBR membranes.…”
Section: Introductionmentioning
confidence: 99%
“…Traditionally, Cur is well-known for its outstanding properties of antioxidant and anti-inflammatory, resulted in widespread application in cancer therapy. Interestingly, recent studies pointed out that Cur could bind to Aβ to lower the aggregation, which is attributed to the π–π stacking interaction and hydrogen bond between Cur and the aromatic residues of Aβ. , Thus, Cur has the potential to be used for AD treatment. However, the low bioavailability caused by its poor solubility remains a major obstacle in clinic application. , It is significant to develop alternative strategies to improve the permeability and accumulation of Cur in brain.…”
Section: Introductionmentioning
confidence: 99%
“…However, the low bioavailability caused by its poor solubility remains a major obstacle in clinic application. 24,25 It is significant to develop alternative strategies to improve the permeability and accumulation of Cur in brain.…”
Section: Introductionmentioning
confidence: 99%